Age at natural menopause and its associated factors in Canada: cross-sectional analyses from the Canadian Longitudinal Study on Aging

Costanian, Christy; McCague, Hugh; Tamim, Hani

doi:10.1097/gme.0000000000000990

Cited by 66 publications

(79 citation statements)

References 52 publications

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“…Increasing risk of earlier menopause has been observed among CLSA women with cardiovascular disease; although the direction of the association remains to be elucidated. 27 Premature menopause has been related to greater cardiovascular risk, 38 diabetes mellitus, 39 depression, 40 osteoporosis, and fracture risk, 41 which could contribute to the associations between premature menopause and lower gait speed found in our study.…”

Section: Discussionmentioning

confidence: 53%

“…42 Premature menopause could also be a marker of perinatal history, earlier social reproductive outcomes and adversities, and poor social and health conditions during adulthood. Using the CLSA, Costanian et al 27 found education to be an important social determinant of earlier menopause. Grip strength levels are related to poor social conditions in early life, including education and income.…”

Section: Discussionmentioning

confidence: 99%

“…The age group 50 to 54 was set as the reference group since it represents the median ANM in women from CLSA (51 years). 27…”

Section: Methodsmentioning

confidence: 99%

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Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging

et al. 2019

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Objective:The aim of this study was to evaluate the association between categories of age at natural menopause (ANM) and gait speed (slowness) and grip strength (weakness), common measures of physical functioning in older women.Methods:We analyzed data from the Canadian Longitudinal Study on Aging, which included participants from seven cities across Canada collected in 2012. The sample was restricted to women who reported to have entered menopause (N = 9,920). Women who had a hysterectomy before menopause were excluded since the age at which this surgical procedure was performed was not available. ANM was categorized into five groups: less than 40 (premature), 40 to 44 (early), 45 to 49, 50 to 54, and more than 54. We conducted linear regressions to assess the association between ANM and gait speed (m/s) and grip strength (kg) adjusting for participant age, education, body mass index, smoking, use of hormone therapy, height, and province of residence.Results:Mean ANM was 49.8 (95% confidence interval [CI]: 49.7-50.0), with 3.8% of women having a premature menopause; the average gait speed was 0.98 m/s (standard deviation: 0.22), the average grip strength was 26.6 kg (standard deviation: 6.39). Compared to women with ANM of 50 to 54, women with premature menopause had 0.054 m/s (95% CI −0.083, −0.026) lower gait speed when adjusting for age and study site. In the fully adjusted model, the association was attenuated, 0.032 m/s (95% CI −0.060, −0.004). ANM was not associated with grip strength.Conclusion:Our study suggests that premature menopause (<40 years) may be associated with lower gait speed (slowness) among Canadian women. No association was observed between ANM and grip strength. Future studies should include a life course approach to evaluate whether social and biological pathways modify the association between age at menopause and physical function in populations from different contexts.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging

et al. 2019

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“…Our study was based on the comprehensive cohort (Comprehensive Baseline Dataset, version 3.0), which includes 30,097 community-dwelling adults aged 45-85 (15,320 women, 14,777 men) who provide data in-person at one of ten data collection sites nationwide. The remainder of CLSA participants, known as the tracking cohort (n = 20,000), provide data by telephone interview and have been previously employed for studies of women's health (15) and frailty (16). The CLSA study design and methods have been previously described by Raina and colleagues (14).…”

Section: Cohort Descriptionmentioning

confidence: 99%

Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging

Tamim

2018

The Journals of Gerontology: Series A

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“…Having no partner, having a low household income and low education levels, being a current and former smoker, and having cardiovascular disease were all associated with an earlier ANM. Meanwhile, current employment, alcohol consumption, and obesity were associated with a later ANM (12) . This means other factors aside from age, genetics and hormones are associated with early or late menopause.…”

mentioning

confidence: 97%

New guidelines, and a new hypertensive population How to select women for menopausal hormone therapy

Romero¹

2018

Rev peru ginecol obstet.

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The 2017 ACC/AHA/AAPA/ABC/ACPM/ AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults published in November 2017(1) designates new categories of blood pressure in adults: Normal <120/140/>90 mm Hg. A previous report based on blood pressure readings in 19.1 million adults pooled from 1 479 studies found that the global age-standardized prevalence of raised blood pressure was 24.1% (21.4–27.1) in men and 20.1% (17.8–22.5) in women in 2015(2). The Peruvian Tornasol II study on Risk Factors for Cardiovascular Diseases reported in 2011 a prevalence of 27.3% for arterial hypertension(3), showing an increase compared to the previous value of 23.7% in 2006(4).

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Age at natural menopause and its associated factors in Canada: cross-sectional analyses from the Canadian Longitudinal Study on Aging

Cited by 66 publications

References 52 publications

Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging

Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging

Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging

New guidelines, and a new hypertensive population How to select women for menopausal hormone therapy

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