Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging

Vélez, Maria P.; Alvarado, Beatriz; Rosendaal, Nicole; Câmara, Saionara Maria Aires da; Bélanger, Emmanuelle; Richardson, Harriet; Pirkle, Catherine M

doi:10.1097/gme.0000000000001362

Cited by 53 publications

(33 citation statements)

References 47 publications

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“…30 Height-adjusted step length was significantly shorter for women beyond 65 years old, but height-adjusted cadence did not differ significantly from early adulthood till 75 years old. Beyond that, the compound effect of accentuated declines in both 31 which has been reported to cause a slowing gait. 32 This could possibly explain for the gradual gait speed decline of our female participants beyond 50 years old.…”

Section: Discussionmentioning

confidence: 97%

<p>Reference Values of Gait Speed and Gait Spatiotemporal Parameters for a South East Asian Population: The Yishun Study</p>

Lau

Wee

Pang

et al. 2020

CIA

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Background: Age-related slowing of gait has been reported to start as early as the fifth decade and accelerate beyond the seventh decade of life. A single cutoff for slow gait may not be appropriate for men and women of different ages. We aimed to report reference values for gait speed and spatiotemporal gait parameters of adult age groups in a South East Asian population. Methods: A total of 507 community-dwelling adults, aged 21-90 years were recruited into the study through random sampling, filling quotas of 20-40 participants in each sex and age group (10-year age groups between 21 and 60 years; 5-year age groups beyond age 60 years). Demographic data, height, weight and information on comorbidities were recorded. Habitual gait speed and spatiotemporal parameters were measured, and the average of three trials was recorded using the GAITRite system. Results: Gait speed peaked in their 40s for both men and women, but the trajectories differed slightly across age groups. Although similar for men in their 50s and 60s, gait speed was significantly slower among those aged 71 years and older. For women beyond 50 years old, gait slowed with age. After adjusting for height, women were found to walk significantly faster and with a longer step length than men. Women also walked with a significantly narrower stride width and less external rotation of the feet. The lowest quintile for gait speed in our study cohort was 0.9m/s, below the recommended cutoff of 1.0m/s. Conclusion: We established the reference values as well as the quintiles for gait speed and spatiotemporal gait parameters across adult age groups in a multi-ethnic Asian population. This contributes to a valuable database for gait assessment and evaluation of preventive or rehabilitative programs.

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Section: Discussionmentioning

confidence: 97%

<p>Reference Values of Gait Speed and Gait Spatiotemporal Parameters for a South East Asian Population: The Yishun Study</p>

Lau

Wee

Pang

et al. 2020

CIA

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“…We used covariates that may influence the association between circuit training and BW: BMI status (obesity vs overweight vs normal weight), intervention type (circuit training alone intervention vs circuit training combined with other lifestyle interventions), age (≥50 vs <50 years), intervention period (≥6 vs <6 months), and sex (men vs women vs men and women). The cut‐off for age (50 years) was based on age at natural menopause and andropause . The cut‐off for the intervention period (6 months) was based on prior reviews .…”

Section: Methodsmentioning

confidence: 99%

Weight loss effects of circuit training interventions: A systematic review and meta‐analysis

2019

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This meta-analysis aimed to assess the weight loss effects of circuit training interventions in adults. A computerized search was conducted using the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE online databases. The analysis was restricted to randomized controlled trials that evaluated the effects of circuit training interventions on body weight and body mass index in adults aged 18 years or older. Meta-analyses were conducted using the random-effect model to estimate the weighted mean difference (WMD) with 95% confidence interval (CI). Nine randomized controlled trials (837 participants) were included. Significant intervention effects were identified for body weight (WMD = −3.81 kg, 95% CI −5.60 to −2.02) and body mass index (WMD = −1.77 kg/m 2 , 95% CI −2.49 to −1.04). Subgroup analysis by body mass index status showed that the intervention effect was significant only in participants with obesity or overweight (obesity: WMD = −5.15 kg, 95% CI −8.81 to −1.50 and overweight: WMD = −3.89 kg, 95% CI −7.00 to −0.77, respectively) but not in those with normal weight. Current evidence suggests that circuit training effectively reduces body weight and body mass index in adults with overweight and obesity. KEYWORDS circuit training, exercise, weight, obesity 1 | INTRODUCTIONThe global prevalence of obesity has considerably increased in recent decades. Globally, in 2016, 13% of adults aged 18 years or older (11% in men; 15% in women) had obesity, and 39% of adults aged 18 years or older (39% in men; 40% in women) were overweight. 1,2 The main cause of overweight and obesity is the energy imbalance between calorie intake and calorie consumption. Globally, the intake of energydense or high-fat foods has increased. Moreover, physical inactivity has increased owing to the increase in sedentary work, changes in the means of transportation, and increased urbanization. 2

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“… 1 Studies of Western populations have shown that approximately 10% of women undergo menopause prior to the age of 45, resulting in a significantly decreased premenopausal estrogen exposure duration relative to women with later-onset menopause. 2 , 3 Muka et al 4 conducted a meta-analysis which revealed an elevated risk of cardiovascular disease (CVD) and mortality among women who undergo early-onset menopause (<45 years).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women

Yao

Liu

et al. 2021

DMSO

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Purpose There is a close correlation between menopausal age and cardiovascular disease (CVD) risk. Some research suggests that this risk is attributable to an elevated urinary albumin-creatinine ratio (UACR), but further work is needed to explore the link between UACR and age at time of menopause. Patients and Methods Data analyzed in the present study were derived from seven regional centers participating in the REACTION study. A total of 21,672 postmenopausal women met with our study inclusion and exclusion criteria, and were split into three groups based upon their age at onset of natural menopause. A UACR ≥ 30 mg/g was the primary outcome measure for this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a logistic regression approach. Results Relative to women who were 46–50 years old at time of natural menopause, those with an earlier onset of menopause (≤45 years) exhibited an increased risk of UACR elevation following adjustment for confounding variables (OR: 1.18, 95% CI: 1.04–1.33), whereas the opposite was true for women with a later age of menopause onset (>50 years) (OR: 0.86, 95% CI: 0.78–0.94). For every 1-year delay in the onset of menopause, UACR risk fell by 3% (OR: 0.97, 95% CI: 0.96–0.98). Conclusion In summary, early menopause (≤45 years old) was linked to a higher risk of UACR elevation in postmenopausal women. However, further work will be needed to understand the mechanistic basis for these findings.

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Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging

Cited by 53 publications

References 47 publications

<p>Reference Values of Gait Speed and Gait Spatiotemporal Parameters for a South East Asian Population: The Yishun Study</p>

<p>Reference Values of Gait Speed and Gait Spatiotemporal Parameters for a South East Asian Population: The Yishun Study</p>

Weight loss effects of circuit training interventions: A systematic review and meta‐analysis

The Relationship Between Earlier Onset of Natural Menopause and Elevated Urinary Albumin-Creatinine Ratio in Postmenopausal Chinese Women

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