Age Changes in the Fine Structure of Anterior Pituitary of the Mouse.

The Aging Cell

“…Since it is known that the mitochondrion is the site of oxidative metabolism, this organelle should assume a major role in the alterations associated with senescence. Results of the electron microscope study of Weiss and Lansing (40) are, in general, in agreement with the results of other studies on changes in the mitochondrion with age. There is swelling and apparent reduction in the mitochondrial matrix.…”

Free Radicals and Health: Indicators for a Unifying Concept

“…Since most oxygen utilization occurs in the mitochondria, these radicals may initiate oxidation polymerization and other reactions involving the unsaturated mitochondrial lipids. The mitochondrial gross changes observed with increasing age—both structurally (49) and biochemically (50, 51)—would be consistent with the theory that they were caused by such free radicals.…”

Secretion of Corticotrophin and Somatotrophin by the Senescent Adenohypophysis in Man

“…Erdheim (1903) demonstrated an increasing accumulation of granu-les of fat in cells in the senile adenohypophysis, causing in vitro vacuolization of the cytoplasm. The mitochondria are transformed into vesicular, fragmentary bodies while the delicate reticular network of the Golgi apparatus is changed into coarse formations comprising argentophil or osmophilic granules (Andrew 1952, Weiss & Lansing 1953, Spagnoli & Charipper 1955, Korenchevsky 1961, Verzár 1966. The changes were interpreted as incipient inactivity of the gamma cells and intensifying activity of the zeta cells.…”