Age changes of human serum polyreactive immunoglobulins (PRIG) activity

Biological and immunochemical properties of polyreactive immunoglobulins

“…10, B), the titers in elderly people are about 3-4 times higher than in the young people. Since (according to literature data [49][50][51]) the concentration of IgG immunoglobulins may in crease with age (by about 5-15%), but considerably less than the found increase of activity of serum IgG PRIG [11], the data estimated by us evidence that specific activity of IgG PRIG per unit of concentra tion of serum immunoglobulins noticeably increases with age.…”

“…12, А). As well as the activity of serum IgM PRIG, which is apparently propor tional to concentration of these molecules in blood sera, activity of serum IgA PRIG of people is con siderably more variable as compared to activity of serum IgG PRIG [11]. At the same time, the avera ge activity of serum IgA PRIG still inconsiderably in creases in elderly people (Fig.…”

“…The activity of serum IgМ and IgА PRIG in the organism varies much more than the activity of IgG PRIG, and the increase of their activity with age either is absent or at least is not so noticeably expressed. The es tablished [11] age changes in the activity of people's PRIG with age, belonging to different classes of im munoglobulins, may evidence both for the immune system degradation with age and probably for an important functional role of these immunoglobulins which still has to be studied. Невідомий раніше феномен набутої поліреактивності сироваткових імуноглобулінів, які було оброблено концентрованими розчи нами хаотропних іонів, таких як KSCN (3,0-5,0 М), а також низьких/високих рН (рН 2,2-3,0/ рН 11,0-12,0) або температурою до 58-60 °С, вперше було описано нами в 1990 p. Знач но пізніше (через одинадцять років) схожі дані було опубліковано J. P. Bouvet зі співавт.…”