Age Correlation of the Time Lag in Signal Change on EPI-fMRI

Taoka, Toshiaki; Iwasaki, Satoru; Uchida, Hideo; Fukusumi, A; Nakagawa, Hiroyuki; Kichikawa, Kimihiko; Takayama, Katsutoshi; Yoshioka, Tetsuya; Takewa, Megumi; Ohishi, Hajime

doi:10.1097/00004728-199807000-00002

Cited by 75 publications

(58 citation statements)

References 14 publications

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“…These age-related changes most likely exert minimal effect on neural function per se, but may underlie the compromised performance of the neurovascular system [22]. Age-related changes in human cerebrovasculature are likely to exert effects on the coupling between neural activity and hemodynamic response [23][24][25][26]. Agerelated changes in noise and signal-noise characteristics of fMRI have also been observed [23].…”

Section: Vascular Density and Vascular Compliance Varies Between Braimentioning

confidence: 99%

Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor

Biswal

Kannurpatti²,

Rypma

2007

Magnetic Resonance Imaging

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AbstractfMRI-BOLD signal representing neural activity may be optimized by discriminating MR signal components related to neural activity and those related to intrinsic properties of the cortical vasculature. The objective of this study was to diminish the hemodynamic change independent of neural activity to obtain a scaled fMRI-BOLD response using two factors namely the low frequency spectral amplitude (LFSA) and breath hold amplitude (BHA). Ten subjects (22-38 years of age) were scanned during various task conditions; (a) rest while breathing room air; (b) bilateral finger-tapping breathing room air; (c) rest during a partial inspirational breath hold; and (d) rest during moderate hypercapnia (breathing 5% CO 2 , 20% O 2 , and 75% N 2 ). In all subjects who breathed 5% CO 2 , regions with significant BOLD response during breath hold correlated significantly with the percent signal increase during 5% CO 2 inhalation. Finger tapping-induced responses in the motor cortex were diminished to a similar extent after scaling using either the LFSA or the BHA. Inter and intra-subject variation in the amplitude of the BOLD signal response reduced after hemodynamic scaling using LFSA or BHA. The results validate the hemodynamic amplitude scaling using the LFSA with earlier established BHA. LFSA free from motor task contamination can be used to calibrate the fMRI-BOLD response in lieu of BHA or hypercapnia to minimize intra and inter subject variation arising from vascular anatomy and vasodilative capacity.

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Section: Vascular Density and Vascular Compliance Varies Between Braimentioning

confidence: 99%

Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor

Biswal

Kannurpatti²,

Rypma

2007

Magnetic Resonance Imaging

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“…Several positron emission tomography (PET) studies have shown age-associated declines of cerebral blood flow (CBF) and cerebral blood volume (CBV) (Frackowiak et al, 1980;Leenders et al, 1990;Martin et al, 1991;Melamed et al, 1980;Pantano et al, 1984), as well as a decrease of the cerebral metabolic rate of glucose (Kuhl et al, 1982) and cerebral metabolic rate of oxygen (CMRO 2 ) (Marchal et al, 1992;Yamaguchi et al, 1986). Various functional imaging methods have identified different cortical neuronal activation patterns during sensory (D'Esposito et al, 1999;Hesselmann et al, 2001;Huettel et al, 2001;Mattay et al, 2002;Mehagnoul-Schipper et al, 2002;Taoka et al, 1998) or cognitive stimuli (for a review see Grady and Craik, 2000) in young and elderly subjects. Since it seems plausible that the aging brain might need to mobilize more resources to produce the same output as a younger one, the recruitment of new brain areas during sensorimotor activation or cognitive perturbations in older subjects has been attributed to compensatory mechanisms for age-related cell changes in some instances (Grady and Craik, 2000).…”

Section: *Department Of Neurology and †Section Of Mr Of The Cns Depamentioning

confidence: 99%

“…Principally, these studies have used functional magnetic resonance imaging (fMRI) techniques to clarify the impact of aging on regional brain activation patterns (D'Esposito et al, 1999;Hesselmann et al, 2001;Huettel et al, 2001;Mattay et al, 2002;Mehagnoul-Schipper et al, 2002;Ross et al, 1997;Taoka et al, 1998). In this context, the utility of fMRI is directly related to the degree to which the relation between MR signal changes and underlying neuronal activation can be established.…”

Section: *Department Of Neurology and †Section Of Mr Of The Cns Depamentioning

confidence: 99%

“…Recently, several fMRI studies have been performed to assess the temporal and spatial characteristics of the fMRI hemodynamic response (HDR) in healthy young and old subjects during sensorimotor (D'Esposito et al, 1999;Hesselmann et al, 2001;Taoka et al, 1998) or visual activation (Huettel et al, 2001;Ross et al, 1997). Whereas HDR waveforms were similar between young and elderly subjects for the visual and sensorimotor cortices in these studies, the spatial extent of activation at a given threshold was significantly reduced in the older subjects.…”

Section: *Department Of Neurology and †Section Of Mr Of The Cns Depamentioning

confidence: 99%

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Relation between Regional Functional MRI Activation and Vascular Reactivity to Carbon Dioxide during Normal Aging

Riecker

Grodd

Klose

et al. 2003

J Cereb Blood Flow Metab

103

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Summary:Recent blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies have shown a reduction of cerebral activation during aging, which may be associated with age-related changes of the cerebral vascular system. The authors used a global hypercapnic breathholding challenge to define nonneuronal contributions to a significantly reduced activation in the primary sensorimotor cortex during finger tapping in a group of old (n ‫ס‬ 6; mean age 65 years) compared with a group of young (n ‫ס‬ 6; mean age 27 years) subjects. Within significantly activated voxels in both groups during finger tapping, the mean BOLD signal amplitudes were significantly smaller in the group of older subjects for both tasks. In those voxels showing significant activation only in young subjects during finger tapping, the response to hypercapnia was also greatly diminished in older subjects. The attenuated hypercapnic BOLD signal response in older subjects within this region suggests that age-dependent changes of the cerebral vasculature may alter the neuronal-vascular coupling. In older subjects, cerebral vessels may not react as effectively in response to a vasodilating stimulus, which will lead to differences in the number of voxels that pass a criterion threshold despite similar neuronal activation.

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“…The rise time of the BOLD signal in response to a simple motor task increases slightly with age (Taoka, et al 1998). Older subjects also exhibit a smaller spatial extent of significant activity and lower signal to noise during a simple visuomotor task (D'Esposito, et al 1999), as well as decreased signal magnitude in a visual cortex, but not a motor cortex .…”

Section: Introductionmentioning

confidence: 98%

Reducing vascular variability of fMRI data across aging populations using a breathholding task

Handwerker¹,

Gazzaley²,

Inglis³

et al. 2006

Human Brain Mapping

129

174

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The magnitude and shape of Blood Oxygen Level Dependent (BOLD) responses in functional Magnetic Resonance Imaging (fMRI) studies vary across brain regions, subjects, and populations. This variability may be secondary to neural activity or vasculature differences, thus complicating interpretations of BOLD signal changes in fMRI experiments. We compare the BOLD responses to neural activity and a vascular challenge and test a method to dissociate these influences in 26 younger subjects (ages 18-36) and 24 older subjects (ages 51-78). Each subject performed a visuomotor saccade task (a vascular response to neural activity) and a breath holding task (vascular dilation induced by hypercapnia) during separate runs in the same scanning session. For the saccade task, signal magnitude showed a significant decrease with aging in FEF, SEF, and V1, and a delayed time-to-peak with aging in V1. The signal magnitudes from the saccade and hypercapnia tasks showed significant linear regressions within subjects and across individuals and populations. These two tasks had weaker, but sometimes significant, linear regressions for time-to-peak and coherence phase measures. The significant magnitude decrease with aging in V1 remained after dividing the saccade task magnitude by the hypercapnia task magnitude implying that the signal decrease is neural in origin. These findings may lead to a method to identify vascular reactivity induced differences in the BOLD response across populations and the development of methods to account for the influence of these vasculature differences in a simple, noninvasive manner.Handwerker, Daniel A 3

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Age Correlation of the Time Lag in Signal Change on EPI-fMRI

Abstract: The time lag in fMRI was revealed to be prolonged with increasing age. Our results suggest that the time lag in fMRI is influenced by some factors associated with aging.

Cited by 75 publications

References 14 publications

Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor

Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor

Relation between Regional Functional MRI Activation and Vascular Reactivity to Carbon Dioxide during Normal Aging

Reducing vascular variability of fMRI data across aging populations using a breathholding task

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