Age-Dependent Change in Metabolic Response to Photic Stimulation of the Primary Visual Cortex in Infants: Functional Magnetic Resonance Imaging Study

Muramoto, Satoshi; Yamada, Hiroki; Sadato, Norihiro; Kimura, Hirohiko; Konishi, Y.; Kimura, Kouki; Tanaka, Masato; Kochiyama, Takanori; Yonekura, Yoshiharu; Ito, Harumi

doi:10.1097/00004728-200211000-00007

Cited by 38 publications

(29 citation statements)

References 38 publications

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“…However Born et al [2002] have detected a decrease in perfusion on activation in sedated children aged 4 -71 months (in contrast to the increase observed in adults and usually assumed to be related to the increase in blood volume). It has been suggested that the change from positive to negative response is due to increased oxygen consumption during stimulation as a result of increased synaptic density, and the results of fitting neonatal data to mathematical models of the BOLD effect are consistent with this [Moramoto et al, 2002].…”

Section: Figurementioning

confidence: 75%

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

103

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Previous studies have demonstrated the use of functional magnetic resonance imaging (fMRI) to assess fetal brain activity. To extend these studies, a fetal fMRI experiment using a visual stimulus has been performed at 0.5 T. This used a block fMRI paradigm with a bright, constant-intensity light source being shone at the maternal abdomen for 8 sec followed by 16 sec of darkness. This was repeated typically 40 times on nine subjects all of whom were greater than 36 weeks gestational age. Of these, one could not be analysed due to motion, three did not show significant activation, and five showed significant activation (P < 0.0085). In all cases, activation was localised within the frontal cortex. Exact localisation was difficult but this may correspond to the frontal eye fields and dorsolateral prefontal cortex. In no cases was significant activation present within the occipital region as would have been expected and was observed in 2/8 adult subjects. Hum. Brain Mapping 20:239-245, 2003.

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Section: Figurementioning

confidence: 75%

Fetal brain activity in response to a visual stimulus

Fulford

Vadeyar

Dodampahala

et al. 2003

Human Brain Mapping

103

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“…Previous studies using both NIRS and MRI have shown that light can sufficiently penetrate closed eyelids in both adults and infants to induce a measurable hemodynamic response over the visual cortex. 25,26 Visual stimulation was provided by a 19-in.-liquid crystal display ͑LCD͒ monitor at a distance of 20 cm from the infant's face. The screen was placed over the top of the bassinet if the infant was lying supine.…”

Section: Protocolmentioning

confidence: 99%

Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

et al. 2010

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Abstract. The neurodevelopmental outcome of neonatal intensive care unit ͑NICU͒ infants is a major clinical concern with many infants displaying neurobehavioral deficits in childhood. Functional neuroimaging may provide early recognition of neural deficits in high-risk infants. Near-infrared spectroscopy ͑NIRS͒ has the advantage of providing functional neuroimaging in infants at the bedside. However, limitations in traditional NIRS have included contamination from superficial vascular dynamics in the scalp. Furthermore, controversy exists over the nature of normal vascular, responses in infants. To address these issues, we extend the use of novel high-density NIRS arrays with multiple source-detector distances and a superficial signal regression technique to infants. Evaluations of healthy term-born infants within the first three days of life are performed without sedation using a visual stimulus. We find that the regression technique significantly improves brain activation signal quality. Furthermore, in six out of eight infants, both oxy-and total hemoglobin increases while deoxyhemoglobin decreases, suggesting that, at term, the neurovascular coupling in the visual cortex is similar to that found in healthy adults. These results demonstrate the feasibility of using high-density NIRS arrays in infants to improve signal quality through superficial signal regression, and provide a foundation for further development of highdensity NIRS as a clinical tool.

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“…These studies have mainly used sensory stimuli in the visual auditory or sensorimotor domain (Born et al 1998;Martin et al 1999;Yamada et al 1997;Muramoto et al 2002). Using passive somatosensorial stimulation, somatosensory areas have been identified in the precentral and postcentral gyri but showed weak hemispheric dominance as compared with the somatosensory system in adults (Erberich et al 2006).…”

Section: Functional Magnetic Resonance Imaging In Infantsmentioning

confidence: 99%

Neuroimaging of cortical development and brain connectivity in human newborns and animal models

et al. 2010

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Significant human brain growth occurs during the third trimester, with a doubling of whole brain volume and a fourfold increase of cortical gray matter volume. This is also the time period during which cortical folding and gyrification take place. Conditions such as intrauterine growth restriction, prematurity and cerebral white matter injury have been shown to affect brain growth including specific structures such as the hippocampus, with subsequent potentially permanent functional consequences. The use of 3D magnetic resonance imaging (MRI) and dedicated postprocessing tools to measure brain tissue volumes (cerebral cortical gray matter, white matter), surface and sulcation index can elucidate phenotypes associated with early behavior development. The use of diffusion tensor imaging can further help in assessing microstructural changes within the cerebral white matter and the establishment of brain connectivity. Finally, the use of functional MRI and resting-state functional MRI connectivity allows exploration of the impact of adverse conditions on functional brain connectivity in vivo. Results from studies using these methods have for the first time illustrated the structural impact of antenatal conditions and neonatal intensive care on the functional brain deficits observed after premature birth. In order to study the pathophysiology of these adverse conditions, MRI has also been used in conjunction with histology in animal models of injury in the immature brain. Understanding the histological substrate of brain injury seen on MRI provides new insights into the immature brain, mechanisms of injury and their imaging phenotype.

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Age-Dependent Change in Metabolic Response to Photic Stimulation of the Primary Visual Cortex in Infants: Functional Magnetic Resonance Imaging Study

Cited by 38 publications

References 38 publications

Fetal brain activity in response to a visual stimulus

Fetal brain activity in response to a visual stimulus

Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

Neuroimaging of cortical development and brain connectivity in human newborns and animal models

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