Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

Liao, Steve M.; Gregg, Nicholas M.; White, Brian R.; Zeff, Benjamin W.; Bjerkaas, Katelin A.; Inder, Terrie E.; Culver, Joseph P.

doi:10.1117/1.3369809

Cited by 54 publications

(57 citation statements)

References 48 publications

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“…The neurovascular interactions during neonatal seizures do not follow the expected increase in HbO and decrease in HbR pattern that has been observed in previous functional studies in newborns [21][22][23] children and adults [24,25] , but similar large abnormal biphasic haemodynamic responses were previously reported by our group in 2011 [7] but in the absence of an electrographic correlate. Recently neurophysiological models of burst-suppression in animals and adults [8,26] have been reported.…”

Section: Discussionsupporting

confidence: 68%

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

Singh

Cooper

Lee

et al. 2016

Advances in Experimental Medicine and Biology

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Neurological brain injuries such as hypoxic ischaemic encephalopathy (HIE) and associated conditions such as seizures have been associated with poor developmental outcome in neonates. Our limited knowledge of the neurological and cerebrovascular processes underlying seizures limits their diagnosis and timely treatment. Diffuse optical tomography (DOT) provides haemodynamic information in the form of changes in concentration of de/oxygenated haemoglobin, which can improve our understanding of seizures and the relationship between neural and vascular processes. Using simultaneous EEG-DOT, we observed distinct haemodynamic changes which are temporally correlated with electrographic seizures. Here, we present DOT-EEG data from two neonates clinically diagnosed as HIE. Our results highlight the wealth of mutually-informative data that can be obtained using DOT-EEG techniques to understand neurovascular coupling in HIE neonates.

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Section: Discussionsupporting

confidence: 68%

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

Singh

Cooper

Lee

et al. 2016

Advances in Experimental Medicine and Biology

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“…Saager and Berger (2005) developed a method of applying a short SDS of 5 mm, which is much less sensitive to deep tissue such as the brain, as a regressor on longer distances and performs a linear regression using a linear minimum mean square estimation (LMMSE) in order to remove the influence of extracerebral layers from the fNIRI signal. This method was successfully tested using fNIRI data from adults (Biallas et al, 2012a;Saager and Berger, 2008;Saager et al, 2011) and newborns (Biallas et al, 2012b;Liao et al, 2010). A similar regression method ('superficial signal regression'), which uses the averages of all short (1.3 cm) SD channels as a regressor, was developed by Gregg et al (2010).…”

Section: Multivariate Methods Of Typementioning

confidence: 99%

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Scholkmann¹,

Kleiser²,

Metz³

et al. 2014

NeuroImage

1,533

1,394

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This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy-and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy-and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. Contents

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“…For example, in human neuroimaging, fluence distributions over many orders of magnitude have been detected and modeled with sufficient signal-to-noise to be capable of reconstructing endogenous chromophore concentrations in the adult 48,49 and infant brain, 50 as well as in brain-mimicking phantoms. 51,52 So, in principle, compensating PA images with DOT measurements should work equally well in an imaging scenario involving larger variations in light fluence.…”

Section: Discussionmentioning

confidence: 99%

Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography

et al. 2011

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Abstract. The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient therefore require an accurate estimation of optical fluence. Light-modeling aided by diffuse optical tomography (DOT) can be used to map the required fluence and to reduce errors in traditional PA spectroscopic analysis. As a proof-ofconcept, we designed a tissue-mimicking phantom to demonstrate how fluence-related artifacts in PA images can lead to misrepresentations of tissue properties. To correct for these inaccuracies, the internal fluence in the tissue phantom was estimated by using DOT to reconstruct spatial distributions of the absorption and reduced scattering coefficients of multiple targets within the phantom. The derived fluence map, which only consisted of low spatial frequency components, was used to correct PA images of the phantom. Once calibrated to a known absorber, this method reduced errors in estimated absorption coefficients from 33% to 6%. These results experimentally demonstrate that combining DOT with PA imaging can significantly reduce fluence-related errors in PA images, while producing quantitatively accurate, high-resolution images of the optical absorption coefficient. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

Cited by 54 publications

References 48 publications

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography

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