Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats

Nešić, Dejan; Stevanović, Darko; Stanković, Sanja; Milošević, Verica; Trajkovič, Vladimir; Starčević, Vesna; Severs, Walter B.

doi:10.1016/j.ejphar.2013.03.052

Cited by 15 publications

(13 citation statements)

References 49 publications

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“…The possibility of reducing the potential negative effect of high cholesterol consumption from meat products by simply including silicon as a functional ingredient is suggested. The C rats registered a lower dietary intake than was previously observed in growing rats fed seaweed-RP diets (6) but was similar to that reported by Nesic et al (32), which is at least partially associated with the anorexic effect of aging (33). Feed intake and weight gain were not significantly modified in the Chol-C group, contrasting with results for cholesterol-fed young rats (5,6).…”

Section: Discussionsupporting

confidence: 77%

Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet1–3

Garcimartín

Santos-López

Bastida

et al. 2015

The Journal of Nutrition

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Section: Discussionsupporting

confidence: 77%

Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet1–3

Garcimartín

Santos-López

Bastida

et al. 2015

The Journal of Nutrition

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“…The perception of taste substances in the gastrointestinal tract causes changes in the level of feeding-related hormones, such as insulin and leptin [33]. Gastrointestinal motility [34–37] and levels of feeding-related hormones in the central nervous system [38] are altered with aging. These results might indicate that aging affects systemic physiological functions.…”

Section: Discussionmentioning

confidence: 99%

Taste preference changes throughout different life stages in male rats

et al. 2017

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Taste preference, a key component of food choice, changes with aging. However, it remains unclear how this occurs. To determine differences in taste preference between rats in different life stages, we examined the consumption of taste solutions and water using a two-bottle test. Male Sprague-Dawley rats of different ages were used: juvenile (3–6 weeks), young adult (8–11 weeks), adult (17–20 weeks), middle-aged (34–37 weeks), and old-aged (69–72 weeks). The intakes of the high and low concentration solutions presented simultaneously were measured. We observed that the old-aged group had lower preference ratios for 0.3 M sucrose and 0.1 M MSG in comparison with other groups. The preference ratio for 0.03 mM QHCl was higher in the middle-aged group than in the three younger groups and higher in the old-aged group than the juvenile group. The taste preferences for HCl and NaCl did not significantly differ among the age groups. The old-aged group tended to prefer high concentrations of sucrose, QHCl, NaCl, and MSG to low concentrations, indicating age-related decline in taste sensitivity. We also aimed to investigate differences between life stages in the electrophysiological responses of the chorda tympani nerve, one of the peripheral gustatory nerves, to taste stimuli. The electrophysiological recordings showed that aging did not alter the function of the chorda tympani nerve. This study showed that aging induced alterations in taste preference. It is likely that these alterations are a result of functional changes in other peripheral taste nerves, the gastrointestinal system, or the central nervous system.

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“…In addition, deletion of GHS-R1a attenuates the age-associated adiposity. In rats, the stimulatory effect of ghrelin on white adipose mass, serum triglyceride, low-density lipoprotein, and cholesterol is more pronounced in older animals relative to peripubertal/young rats [24]. The higher responsiveness to ghrelin-induced increase in lipid metabolite in aged rats is associated with an increase in adrenocorticotropic hormone and corticosterone levels.…”

Section: Ghrelin and Age-associated Impairment In Energy Metabolismmentioning

confidence: 99%

The Role of Ghrelin in Senescence: A Mini-Review

Yin

Zhang

2015

Gerontology

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Ghrelin, a 28-amino acid hormone produced mainly by the X/A-like endocrine cells in gastric mucosa, has a widespread tissue distribution and diverse physiological functions such as hormonal, orexigenic, metabolic, cardiovascular, neurological, and immunological activities. Considerable evidence has suggested that ghrelin plays an important role in organism senescence or aging. The present review provides a comprehensive picture of this new development. We first reviewed the aging (senescence)-dependent reduction of ghrelin signaling, and then highlighted its relationship with the aging-associated alteration in food intake, energy metabolism, cardiovascular function, neurological activity, and adaptive immunity. Our literature review suggests that ghrelin is an innovative and promising agent in the treatment of these pathophysiological conditions associated with senescence.

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Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats

Cited by 15 publications

References 49 publications

Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet1–3

Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet1–3

Taste preference changes throughout different life stages in male rats

The Role of Ghrelin in Senescence: A Mini-Review

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