Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet1–3

Garcimartín, Alba; Santos-López, Jorge Arturo; Bastida, Sara; Benedı́, Juana; Sánchez‐Muniz, Francisco J.

doi:10.3945/jn.115.213934

Cited by 23 publications

(53 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This protection was more effective than HxT and suggests an inhibition effect over ROS (mainly hydrogen peroxide) and regulation of antioxidant enzymes expressions and activities giving rise to lower GSSG levels. These results, together with previous one of our group [ 11 , 12 , 17 ], stress the importance of incorporating Si into the diet; nonetheless, further studies on other animal and human models should be performed.…”

Section: Discussionsupporting

confidence: 76%

“…The hypothesis of the present work is that Si-enriched RP may act as a functional food by reducing liver oxidative status in aged rats fed a high-saturated/high-cholesterol diet as a model of NASH. These results would be joined to previous ones obtained in vitro [ 11 , 12 ] and in vivo [ 17 ] opening discussion on the potential pleiotropic antioxidant effects of Si.…”

Section: Introductionmentioning

confidence: 61%

“…Very recently our group has proven that Si added to RP strongly counterbalanced the negative effect of high-cholesterol-ingestion, functioning as an active hypocholesterolemic dietary ingredient in aged rats. In addition it helped to normalize VLDL composition and reduce VLDL oxidation in aged rats [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundPork is an essential component of the diet that has been linked with major degenerative diseases and development of non-alcoholic steatohepatitis (NASH). Previous studies have. Previous studies have demonstrated the in vitro antioxidant activity of silicon (Si). Furthermore, when Si is added to restructured pork (RP) strongly counterbalances the negative effect of high-cholesterol-ingestion, acting as an active hypocholesterolemic and hypolipemic dietary ingredient in aged rats.ObjectiveThis study was designed to evaluate the effects of Si vs hydroxytyrosol (HxT) RP on liver antioxidant defense in aged rats fed cholesterol-enriched high saturated/high cholesterol diets as a NASH model.MethodsFour diets were prepared: Control RP diet (C) with non-added cholesterol; Cholesterol-enriched high-saturated/high-cholesterol control RP diet (CHOL-C) with added cholesterol and cholic acid; Si- or HxT-RP cholesterol-enriched high-saturated/high-cholesterol diets (CHOL-Si and CHOL-HxT). Groups of six male Wistar rats (1-yr old) were fed these modified diets for eight weeks. Total cholesterol, hepatosomatic index, liver Nrf2 and antioxidant (CAT, SOD, GSH, GSSG, GR, GPx) markers were determined.ResultsBoth CHOL-Si and CHOL-HxT diets enhanced the liver antioxidant status, reduced hepatosomatic index and increased SOD actvity. Hydrogen peroxide removal seemed to be involved, explaining that the value of redox index was even lower than C without changing the CAT activity. CHOL-Si results were quite better than CHOL-HxT in most measured parameters.ConclusionsOur study suggests that Si incorporated into RP matrix was able to counterbalance, more efficiently than HxT, the deleterious effect of consuming a high-saturated/high-cholesterol diet, by improving the liver antioxidant defenses in the context of NASH.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 61%

See 1 more Smart Citation

Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies indicate that different forms of silicon dioxide affect metabolic parameters such as blood lipids and weight. [ 19–22 ] Thus, another potential biomedical application of MSP could be in the treatment of the metabolic syndrome, including obesity and T2D. In the present study, we report the effects of oral intake of MSP on metabolic biomarkers in a first‐in‐man study in ten healthy individuals with obesity.…”

Section: Introductionmentioning

confidence: 99%

Entrapping Digestive Enzymes with Engineered Mesoporous Silica Particles Reduces Metabolic Risk Factors in Humans

Waara

Iqbal

Robert‐Nicoud

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Engineered mesoporous silica particles (MSP) are thermally and chemically stable porous materials composed of pure silica and have attracted attention for their potential biomedical applications. Oral intake of engineered MSP is shown to reduce body weight and adipose tissue in mice. Here, clinical data from a first‐in‐humans study in ten healthy individuals with obesity are reported, demonstrating a reduction in glycated hemoglobin (HbA1c) and low‐density lipoprotein cholesterol, which are well‐established metabolic and cardiovascular risk factors. In vitro investigations demonstrate sequestration of pancreatic α‐amylase and lipase in an MSP pore‐size dependent manner. Subsequent ex vivo experiments in conditions mimicking intestinal conditions and in vivo experiments in mice show a decrease in enzyme activity upon exposure to the engineered MSP, presumably by the same mechanism. Therefore, it is suggested that tailored MSP act by lowering the digestive enzyme availability in the small intestine, resulting in decreased digestion of macronutrient and leading to reduced caloric uptake. This novel MSP based mechanism‐of‐action, combined with its excellent safety in man, makes it a promising future agent for prevention and treatment of metabolic diseases.

show abstract

“…Food technology is responsible for quantitative and qualitative modifications in meat and meat matrices creating functional meat products. Our group has done extensive work on restructured pork (RP) enriched with different ingredients such as algae, omega-3 fatty acids and minerals [ 8 , 9 ]. Those RP must be able to provide a beneficial effect on one or more selective body functions, improving health and wellness while reducing the risk of disease [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Glucomannan- and glucomannan plus spirulina-enriched pork affect liver fatty acid profile, LDL receptor expression and antioxidant status in Zucker fa/fa rats fed atherogenic diets

González‐Torres

Matos

Vázquez‐Velasco

et al. 2016

Food & Nutrition Research

Self Cite

View full text Add to dashboard Cite

We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP) on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC (cholesterol-enriched control), HG and HGS (cholesterol-enriched glucomannan and glucomannan/spirulina-RP) experimental diets were tested. Increased metabolic syndrome markers were found in C, G and GS rats. Cholesterol feeding increased liver size, fat, and cholesterol and reduced antioxidant enzyme levels and expressions. Cholesterolemia was lower in HG and HGS than in HC. GS vs. G showed higher stearic but lower oleic levels. SFA and PUFA decreased while MUFA increased by cholesterol feeding. The arachidonic/linoleic and docosahexaenoic/alpha-linolenic ratios were lower in HC, HG, and HGS vs. C, G, and GS, respectively, suggesting a delta-6-elongase-desaturase system inhibition. Moreover, cholesterol feeding, mainly in HGS, decreased low-density-lipoprotein receptor expression and the delta-5-desaturase activity and increased the delta-9-desaturase activity. In conclusion, the liver production of highly unsaturated fatty acids was limited to decrease their oxidation in presence of hypercholesterolaemia. Glucomannan or glucomannan/spirulina-RP has added new attributes to their functional properties in meat, partially arresting the negative effects induced by high-fat-high-cholesterol feeding on the liver fatty acid and antioxidant statuses.

show abstract

Silicon-Enriched Restructured Pork Affects the Lipoprotein Profile, VLDL Oxidation, and LDL Receptor Gene Expression in Aged Rats Fed an Atherogenic Diet1–3

Abstract: Silicon added to RP strongly counterbalanced the negative effect of high-cholesterol-ingestion, functioning as an active hypocholesterolemic, hypolipemic, and antioxidative dietary ingredient in aged rats.

Cited by 23 publications

References 46 publications

Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets

Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets

Entrapping Digestive Enzymes with Engineered Mesoporous Silica Particles Reduces Metabolic Risk Factors in Humans

Glucomannan- and glucomannan plus spirulina-enriched pork affect liver fatty acid profile, LDL receptor expression and antioxidant status in Zucker fa/fa rats fed atherogenic diets

Contact Info

Product

Resources

About