Age dependent neuroprotective effects of medhya rasayana prepared from Clitoria ternatea Linn. in stress induced rat brain

Raghu, Kothanahalli S.; Shamprasad, Bhanuvalli R.; Kabekkodu, Shama Prasada; Paladhi, Puspendu; Joshi, Manjunath B.; Valiathan, Manna; Guruprasad, Kanive Parashiva; Satyamoorthy, Kapaettu

doi:10.1016/j.jep.2016.07.068

Cited by 25 publications

(13 citation statements)

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“…A more recent study of the effects of C. ternatea leaf extracts on diabetic-induced cognitive decline showed that the acetylcholinesterase activity, total nitric oxide levels and lipid peroxide levels all significantly decreased upon treatment, whilst the catalase, superoxide dismutase and glutathione levels all significantly increased (Talpate et al, 2014). Another recent study showed that rats fed for 60 days with “medhya rasayana,” a mixture of crushed C. ternatea and jaggery (1:1), exhibited significant reduction in autophagy in the brain (Raghu et al, 2017). The treated and the control rats also differentially expressed genes implicated in autophagy regulation, nucleotide excision repair, homologous recombination, etc.…”

Section: Historical and Current Applicationsmentioning

confidence: 99%

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Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

et al. 2019

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The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant interest based on its agricultural and medical applications, which range from use as a fodder and nitrogen fixing crop, to applications in food coloring and cosmetics, traditional medicine and as a source of an eco-friendly insecticide. In this article we provide a broad multidisciplinary review that includes descriptions of the physical appearance, distribution, taxonomy, habitat, growth and propagation, phytochemical composition and applications of this plant. Notable amongst its repertoire of chemical components are anthocyanins which give C. ternatea flowers their characteristic blue color, and cyclotides, ultra-stable macrocyclic peptides that are present in all tissues of this plant. The latter are potent insecticidal molecules and are implicated as the bioactive agents in a plant extract used commercially as an insecticide. We include a description of the genetic origin of these peptides, which interestingly involve the co-option of an ancestral albumin gene to produce the cyclotide precursor protein. The biosynthesis step in which the cyclic peptide backbone is formed involves an asparaginyl endopeptidase, of which in C. ternatea is known as butelase-1. This enzyme is highly efficient in peptide ligation and has been the focus of many recent studies on peptide ligation and cyclization for biotechnological applications. The article concludes with some suggestions for future studies on this plant, including the need to explore possible synergies between the various peptidic and non-peptidic phytochemicals.

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Section: Historical and Current Applicationsmentioning

confidence: 99%

“…The treated and the control rats also differentially expressed genes implicated in autophagy regulation, nucleotide excision repair, homologous recombination, etc. The study suggested that C. ternatea protects the brain by affecting the autophagy directed pathway (Raghu et al, 2017).…”

Section: Historical and Current Applicationsmentioning

confidence: 99%

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

et al. 2019

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“…Medhya Rasayana, a memory enhancer formulation prepared from a mixture of selected plants and their extracts, has a great ability to promote brain rejuvenation, triggering a marginal but sustained increase in constitutive DNA base excision repair in brain tissues of adult rats [51].…”

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confidence: 99%

Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs

Sharma

Martins

2020

JCM

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“…The genetic inhibition of autophagy such as the disruption of Atg7 often leads to apoptosis or necrotic cell death, clearly indicating that the inhibition of autophagy leads to the activation or upregulation of apoptosis [ 69 ]. In contrast, the artificial activation of autophagy could have neuroprotective effects in the aging brain by maintaining the selective DNA damage repair pathway and the removal of ROS to inhibit apoptosis [ 70 ]. Both of these are also important for repairing damage to the BBB.…”

Section: Discussionmentioning

confidence: 99%

Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

Xia

Gao

Peng

et al. 2022

IJMS

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Aging is a process associated with blood–brain barrier (BBB) damage and the reduction in neurogenesis, and is the greatest known risk factor for neurodegenerative disorders. However, the effects of Fe3O4 nanozymes on neurogenesis have rarely been studied. This study examined the effects of Fe3O4 nanozymes on neuronal differentiation in the dentate gyrus (DG) and BBB integrity of D-galactose-induced aged mice. Long-term treatment with Fe3O4 nanozymes (10 μg/mL diluted in ddH2O daily) markedly increased the doublecortin (DCX) immunoreactivity and decreased BBB injury induced by D-galactose treatment. In addition, the decreases in the levels of antioxidant proteins including superoxide dismutase (SOD) and catalase as well as autophagy-related proteins such as Becin-1, LC3II/I, and Atg7 induced by D-galactose treatment were significantly ameliorated by Fe3O4 nanozymes in the DG of the mouse hippocampus. Furthermore, Fe3O4 nanozyme treatment showed an inhibitory effect against apoptosis in the hippocampus. In conclusion, Fe3O4 nanozymes can relieve neuroblast damage and promote neuroblast differentiation in the hippocampal DG by regulating oxidative stress, apoptosis, and autophagy.

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Age dependent neuroprotective effects of medhya rasayana prepared from Clitoria ternatea Linn. in stress induced rat brain

Cited by 25 publications

References 43 publications

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs

Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

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