Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

Xia, Zihao; Gao, Manman; Peng, Sheng; Shen, Mengmeng; Zhang, Lin; Gao, Lizeng; Yan, Bingchun

doi:10.3390/ijms23126463

Cited by 11 publications

(3 citation statements)

References 86 publications

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“…A study by Yan et al showed that the addition of the PEG-modified Fe 3 O 4 nanozyme to mouse chow, reduced neuronal damage due to ischemic stroke and maintained the integrity of the BBB. A study by Xia et al showed the same conclusion that long-term use of the PEG-modified Fe 3 O 4 nanozyme (10 μg/mL per day, ddH 2 O dilution) significantly improved the immunoreactivity of double corticosteroid (DCX) and reduced d-galactose-induced BBB damage.…”

Section: Therapeutic Application Of Disease Microenvironment Remodeli...mentioning

confidence: 77%

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Liu

et al. 2023

ACS Appl. Nano Mater.

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Nanomaterials that can mimic the activity of various enzymes have been studied extensively in the biomedical field in recent years. Nanozymes offer better stability and economic value in comparison to natural enzymes. Additionally, nanozymes have characteristics of nanomaterials, such as photothermal properties and designability, and therefore have considerable potential. The cellular microenvironment provides the basis for maintaining normal cell growth and function. Increasing evidence shows that imbalances in the homeostasis of the cellular microenvironment constitute a major factor in the development of many diseases. Nanozymes have received considerable attention in recent years as regulators of the cellular microenvironment. In this Review, research on the use of nanozymes to remodel the disease microenvironment is discussed. First, the definition, classification, and enzyme-like activities of nanozymes are introduced; several major disease microenvironments are summarized including tumor, inflammatory, and trauma microenvironments. The role of nanozymes in disease microenvironments and the main strategies for constructing intelligent and responsive nanozyme systems are discussed. The specific applications of nanozymes in remodeling the diseased microenvironment are highlighted. Finally, the therapeutic strategies of nanozymes to remodel the disease microenvironment are summarized and prospected. Nanozyme disease microenvironment remodeling is expected to become a major therapeutic strategy or an adjunct for the prevention and treatment of related diseases.

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Section: Therapeutic Application Of Disease Microenvironment Remodeli...mentioning

confidence: 77%

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Liu

et al. 2023

ACS Appl. Nano Mater.

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“…The strong antioxidant qualities of IONPs in postponing animal aging and reducing ROS-induced neurotoxicity were further confirmed by the Drosophila AD model [301]. Fe 3 O 4 nanozymes showed a potent mitigative effect against d-galactose-induced oxidative damage of the neuroblast as well as apoptosis and autophagy in the hippocampal dentate gyrus [303]. IONPs showed potential application in the diagnosis and treatment of different neurodegenerative diseases, such as AD, PD, and ALS [304].…”

Section: Iron-based Nps (Ionps) and Their Antioxidant Conjugates To A...mentioning

confidence: 82%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death. This advances the development of neuroinflammation and neurodegeneration-associated disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, and other memory disorders. It is imperative to treat such conditions as early as possible before they worsen and progress to irreversible damage. Oxidative damage can be negated by two mechanisms: improving the cellular defense system or providing exogenous antioxidants. Natural antioxidants can normally handle such oxidative stress, but they have limited efficacy. The valuable features of nanoparticles and/or nanomaterials, in combination with antioxidant features, offer innovative nanotheranostic tools as potential therapeutic modalities. Hence, this review aims to represent novel therapeutic approaches like utilizing nanoparticles with antioxidant properties and nanotheranostics as delivery systems for potential therapeutic applications in various neuroinflammation- and neurodegeneration-associated disease conditions.

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“…An imbalance leading to excessive ROS levels can result in increased oxidative stress, which is implicated in various diseases and aging-related processes. Conditions commonly associated with oxidative stress include neurodegenerative diseases, , cardiovascular diseases, , and inflammatory disorders (Figure ). Most notably, SAzymes, mimicking peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD), hold the potential for modulating ROS levels in regeneration medicine (Figure ).…”

Section: Mechanism Of Sazymesmentioning

confidence: 99%

Single-Atom-Based Nanoenzyme in Tissue Repair

Fu,

Fan,

et al. 2024

ACS Nano

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Since the discovery of ferromagnetic nanoparticles Fe 3 O 4 that exhibit enzyme-like activity in 2007, the research on nanoenzymes has made significant progress. With the in-depth study of various nanoenzymes and the rapid development of related nanotechnology, nanoenzymes have emerged as a promising alternative to natural enzymes. Within nanozymes, there is a category of metal-based single-atom nanozymes that has been rapidly developed due to low cast, convenient preparation, long storage, less immunogenicity, and especially higher efficiency. More importantly, single-atom nanozymes possess the capacity to scavenge reactive oxygen species through various mechanisms, which is beneficial in the tissue repair process. Herein, this paper systemically highlights the types of metal single-atom nanozymes, their catalytic mechanisms, and their recent applications in tissue repair. The existing challenges are identified and the prospects of future research on nanozymes composed of metallic nanomaterials are proposed. We hope this review will illuminate the potential of singleatom nanozymes in tissue repair, encouraging their sequential clinical translation.

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Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

Cited by 11 publications

References 86 publications

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Single-Atom-Based Nanoenzyme in Tissue Repair

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