Age-dependent physiochemical and biochemical studies of human red cell membranes

Hegner, D.; Platt, D.; Heckers, H.; Schloeder, U.; Breuninger, V.

doi:10.1016/0047-6374(79)90075-7

Cited by 42 publications

(5 citation statements)

References 42 publications

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“…Under normal conditions the red cell membrane is semifluid (Lee et al, 1973;Singer and Nicolson, 1972). The red cell membrane has a markedly different composition as well as being rigid in the stroke prone age group relative to subjects less than 30 years of age (Hegner et al, 1979). The relationship between hematocrit, viscosity and cerebral blood flow, TIA and stroke (Thomas et al, 1977) deserves further consideration.…”

Section: Discussionmentioning

confidence: 99%

Ocular and Cerebral Ischemic Mechanisms in Disease of the Internal Carotid Artery

Ross

Morrow

1984

Can. j. neurol. sci.

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ABSTRACT:Stenosis of the internal carotid artery reduces the flow velocity in the ophthalmic artery. Lowered velocity permits increased red cell aggregation and decreased red cell deformability which increases viscosity.Contrary to the theory of remotely originating emboli, this is an alternate hypothesis regarding transient attacks of ocular and cerebral ischemia.The ophthalmic artery circulation time was measured in two groups of patients. The circulation time was defined as the interval between the appearance of contrast media in the siphon of the internal carotid artery and in the ocular choroid. The measurement was made on 151 angiograms of 108 subjects. These vessels were normal. An additional 76 patients had 108 angiograms which showed various amounts of internal carotid artery stenosis. These 76 patients had transient ischemic attacks; retinal, cerebral, or both.There is a significant difference in the ophthalmic artery circulation time in the two groups. The slowing in the ophthalmic artery is related to the degree of internal carotid artery narrowing.The circulation time in a cerebral branch of the internal carotid was not measured. It is presumed that stenosis of the internal carotid artery would have the same effect on a cerebral artery as on the ophthalmic artery.

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Section: Discussionmentioning

confidence: 99%

Ocular and Cerebral Ischemic Mechanisms in Disease of the Internal Carotid Artery

Ross

Morrow

1984

Can. j. neurol. sci.

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“…These include a decline in the number of dopaminergic neurons in the substantia nigra [10•, 50], a decrease in binding sites for dopamine throughout various regions of the brain (including the basal ganglia) [51], and alterations in the downstream signaling following dopamine receptor binding [52]. These changes are important because older adult patients experience more adverse effects at a given level of dopamine receptor occupancy compared with younger adults [53].…”

Section: Mechanismsmentioning

confidence: 99%

Sensitivity to Antipsychotic Drugs in Older Adults

Leon

Gerretsen

Uchida

et al. 2010

Curr Psychiatry Rep

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Antipsychotic medications are widely used to manage psychotic and behavioral disorders in older adults, including primary psychotic disorders such as schizophrenia, and psychosis and behavioral disturbances associated with dementia. These two broad diagnostic indications are associated with contrasting recommended treatment durations, with the former requiring indefinite treatment across the life span. Antipsychotic drug dosing for schizophrenia is based primarily on studies of younger patients and thus may not apply to older adults. It is critically important to address the effects of aging on antipsychotic dosing given the recent emergence of data that suggest a critical role for age-related sensitivity to these drugs. Antipsychotic drugs are not only associated with somatic and neurological adverse effects but also increased all-cause mortality and sudden cardiac death in this vulnerable population. This review focuses on the sensitivity of older adults to adverse effects from antipsychotic medications and the current pharmacokinetic and pharmacodynamic explanatory models of susceptibility. Implications of recent research findings for individualized pharmacotherapy are discussed.

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“…Advancing donor age is associated with multiple deleterious changes in RBC properties, including increased fragility (Detraglia et al 1974;Bowdler et al 1981), morphological changes (Bowdler et al 1981), and decreases in membrane fluidity and deformability (Reid et al 1976;Hegner et al 1979;Gelmini et al 1987Gelmini et al , 1989. Among these, the age-associated decline in RBC antioxidant capacity (Glass & Gershon, 1984;Gershon & Gershon, 1988;Gil et al 2006;Rizvi & Maurya, 2007;Chaleckis et al 2016) is likely one of the most detrimental given that RBCs can generate substantial amounts of reactive oxygen/nitrogen species (Johnson et al 2005;Cimen, 2008;Rifkind & Nagababu, 2013;Kuhn et al 2017), which cause oxidative damage that has been clearly linked to decreased RBC deformability (Haest et al 1977;Wang et al 1999;Tsantes et al 2006;Rifkind & Nagababu, 2013;Mohanty et al 2014;Xiong et al 2017).…”

Section: Potential Causes Of Decreased Rbc Deformability With Advancimentioning

confidence: 99%

“…Although the underlying mechanisms of this impairment in RBC ATP release are unknown, one possibility is the age-associated decrease in RBC membrane fluidity and deformability (Reid et al 1976;Hegner et al 1979;Gelmini et al 1987Gelmini et al , 1989. In this context, it has been demonstrated that acute, pharmacologically induced increases or decreases in RBC deformability produce parallel changes in deoxygenation-induced ATP release from RBCs of young healthy donors (Thuet et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans

Racine

Dinenno

2019

The Journal of Physiology

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Red blood cells (RBCs) release ATP in response to deoxygenation, which can increase blood flow to help match oxygen supply with tissue metabolic demand. r This release of ATP is impaired in RBCs from older adults, but the underlying mechanisms are unknown. r In this study, improving RBC deformability in older adults restored deoxygenation-induced ATP release, whereas decreasing RBC deformability in young adults reduced ATP release to the level of that of older adults. r In contrast, treating RBCs with a phosphodiesterase 3 inhibitor did not affect ATP release in either age group, possibly due to intact intracellular signalling downstream of deoxygenation as indicated by preserved cAMP and ATP release responses to pharmacological G i protein activation in RBCs from older adults. r These findings are the first to demonstrate that the age-related decrease in RBC deformability is a primary mechanism of impaired deoxygenation-induced ATP release, which may have implications for treating impaired vascular control with advancing age.

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Age-dependent physiochemical and biochemical studies of human red cell membranes

Cited by 42 publications

References 42 publications

Ocular and Cerebral Ischemic Mechanisms in Disease of the Internal Carotid Artery

Ocular and Cerebral Ischemic Mechanisms in Disease of the Internal Carotid Artery

Sensitivity to Antipsychotic Drugs in Older Adults

Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans

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