Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Jin, Jian; Xin, Yang; Flavel, Matthew; Shields, Zenaida P.; Neoh, Julian; Bowen, Mae-Ling; Kitchen, Barry J.

doi:10.3390/cosmetics7020030

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Nonetheless, the amount of information on this subject is still very few. In addition, a polyphenol rich sugarcane concentrate (Officinol™) has been shown to inhibit tyrosinase and elastase activities 116 . The same effect caused by sugarcane polyphenols is reported by Carvalho et al 24 In this work, it is possible to observe that the inhibitory effect was concentration dependent, as it was higher at higher concentrations.…”

Section: Resultssupporting

confidence: 72%

“…In addition, a polyphenol rich sugarcane concentrate (Officinol™) has been shown to inhibit tyrosinase and elastase activities. 116 The same effect caused by sugarcane polyphenols is reported by Carvalho et al 24 In this work, it is possible to observe that the inhibitory effect was concentration dependent, as it was higher at higher concentrations. However, the two highest concentrations exert a very similar inhibitory effect, suggesting that, at these concentrations, the highest possible inhibitory effect produced by this sample could have almost been reached.…”

Section: Skin Enzymes Inhibitionsupporting

confidence: 81%

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Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae

Duarte

Carvalho

et al. 2023

BioFactors

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Postbiotics are defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” They can be produced by fermentation, using culture media with glucose (carbon source), and lactic acid bacteria of the genus Lactobacillus, and/or yeast, mainly Saccharomyces cerevisiae as fermentative microorganisms. Postbiotics comprise different metabolites, and have important biological properties (antioxidant, anti‐inflammatory, etc.), thus their cosmetic application should be considered. During this work, the postbiotics production was carried out by fermentation with sugarcane straw, as a source of carbon and phenolic compounds, and as a sustainable process to obtain bioactive extracts. For the production of postbiotics, a saccharification process was carried out with cellulase at 55°C for 24 h. Fermentation was performed sequentially after saccharification at 30°C, for 72 h, using S. cerevisiae. The cells‐free extract was characterized regarding its composition, antioxidant activity, and skincare potential. Its use was safe at concentrations below ~20 mg mL−1 (extract's dry weight in deionized water) for keratinocytes and ~ 7.5 mg mL−1 for fibroblasts. It showed antioxidant activity, with ABTS IC50 of 1.88 mg mL−1, and inhibited elastase and tyrosinase activities by 83.4% and 42.4%, respectively, at the maximum concentration tested (20 mg mL−1). In addition, it promoted the production of cytokeratin 14, and demonstrated anti‐inflammatory activity at a concentration of 10 mg mL−1. In the skin microbiota of human volunteers, the extract inhibited Cutibacterium acnes and the Malassezia genus. Shortly, postbiotics were successfully produced using sugarcane straw, and showed bioactive properties that potentiate their use in cosmetic/skincare products.

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Section: Resultssupporting

confidence: 72%

Section: Skin Enzymes Inhibitionsupporting

confidence: 81%

Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae

Duarte

Carvalho

et al. 2023

BioFactors

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“…The natural antimicrobials market is expected to grow at an annual compound growth rate of 7.3% over the period 2019–2024, because multidrug-resistant food-borne pathogens have prompted the search for natural and cheaper antimicrobials that can replace the synthetic agents, representing a high economic impact [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient

Oliveira¹,

Carvalho²,

Oliveira³

et al. 2022

Foods

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The sugarcane processing industry generates a large amount of straw, which has a negative environmental impact, and high costs are associated with their elimination, wasting their potential bioactive value attributed to their richness in polyphenols. In this study, an ethanolic extract produced from sugarcane straw was screened for its phenolic compounds content, and the potential use of this extract in the development of a food ingredient was further evaluated. Fifty different secondary metabolites belonging to the hydroxybenzoic acids, hydroxycinnamic acids, and flavonoids were identified by liquid chromatography–electrospray ionization–ultrahigh-resolution—quadrupole time of flight–mass spectrometry (LC-ESI-UHR-QqTOF-MS). The predominant phenolic compounds found were 4-hydroxybenzaldehyde, chlorogenic acid, and 5-O-feruloylquinic acid. The obtained extracts showed strong potential as food preservatives by exhibiting (a) antioxidant activity using both 2.2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt radical cation (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods; and (b) antimicrobial capacity, with a minimum inhibitory concentration of 50 mg/mL for Staphylococcus aureus, 74% inhibition for Bacillus cereus, and 44% for Salmonella enterica; and (c) the capacity to inhibit a food browning enzyme, tyrosinase (28–73% for 1–8 mg/ mL). Moreover, the extracts showed antidiabetic potential by inhibiting the enzymes α-glucosidase (15–38% for 1.25–5.00 mg/mL) and dipeptidyl peptidase-IV (DPP-IV) (62–114% for 0.31–5.00 mg/mL). The extract (0.625 mg/mL) also exhibited the capacity to reduce proinflammatory mediators (i.e., interleukins 6 and 8, and tumor necrosis factor alpha) when Caco-2 cells were stimulated with interleukin 1 beta. Thus, sugarcane straw extract, which is rich in phenolic compounds, showed high potential to be used in the development of food-preservative ingredients owing to its antioxidant and antimicrobial potential, and to be explored as a food supplement in diabetes prevention and as coadjuvant to reduce intestinal inflammation by reducing proinflammatory mediators.

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“…A novel preparation named "polyphenol-rich sugarcane extract" (PRSE) has been shown to have a large concentration of both polyphenols and other antioxidant compounds, and has been shown to have some beneficial effects on energy uptake and metabolism in cancer cells, as well as being able to impact the actions of insulin-secreting pancreatic β-cells [24]. It is also able to impart benefits in diabetes, has anti-bacterial effects and improves the cosmetic effects of aging in the skin [25]. PRSE has also been shown to modulate the immune system, with effects on inflammation, cancer and neurological disorders [26,27].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

et al. 2021

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As inflammatory lifestyle factors become more prevalent and as the population ages, the management of inflammation will become increasingly relevant. Plant polyphenols are powerful antioxidants that are known to have beneficial effects in a number of diseases with an inflammatory or oxidative component, such as malignancy, cardiovascular disease and arthritis. Polyphenol-rich sugarcane extract (PRSE) is a novel preparation with high concentrations of polyphenolic antioxidants, with some evidence to show benefits in health, but there is limited research investigating its effects on immunomodulation. This study determined the effects of PRSE on human monocyte cells in vitro. We show that PRSE has an immunomodulatory effect in U937 human monocyte cells, altering the expression of cellular surface markers, with an increased expression of CD16 and CD11b, as well as small changes in CD40, CD80, CD80, CD206 and MHCI. It also modulates the profile of secreted cytokines, increasing IL-1β, TNFα, IL-6, IL-8, IL-4 and IL-10. These changes are consistent with the advanced differentiation of the monocyte, as well as the switch from the M1 to M2 phenotype in macrophages. We also demonstrate that this effect is likely to be independent of the NF-κB signalling pathway, suggesting that other mechanisms drive this effect. PRSE exerts an immunomodulatory effect on U937 monocytes in vitro, potentially facilitating the conversion from inflammation to healing. Future studies should identify specific mechanisms underlying the changes and evaluate their effectiveness in animal models of disease.

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Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Cited by 11 publications

References 27 publications

Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae

Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae

Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

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