Depression and neuroticism decrease among women but not among men between 1976 and 2016 in Swedish septuagenarians Rydberg Sterner T, Gudmundsson P, Sigstr€ om R, Ahlner F, Seidu N, Zettergren A, Kern S, € Ostling S, Waern M, Skoog I. Depression and neuroticism decrease among women but not among men between 1976 and 2016 in Swedish septuagenarians Objectives: We evaluated birth-cohort differences in depressive symptom burden, prevalence of depression diagnoses, and neuroticism, among Swedish 70-year-olds examined between 1976 and 2016. Methods: We used a repeated cross-sectional design examining four representative population samples of Swedish 70-year-olds (total n = 2279) with identical methods in 1976-77 (n = 392), 1992-93 (n = 226), 2000-02 (n = 487), and 2014-16 (n = 1166). Depressive symptom burden was rated with the Montgomery Asberg Depression Rating Scale. Major depression was diagnosed according to DSM-5, and minor depression according to DSM-IV-TR research criteria. Neuroticism was rated with the Eysenck Personality Inventory.Results: For women in 2014-16, MADRS score (4.4 vs. 6.1 vs. 5.8; P < 0.05) and neuroticism (6.6 vs. 7.7 vs. 9.2; P < 0.05) were lower compared with 1992-93 and 1976-77, and the prevalence of any depression was lower compared with 2000-02 and 1992-93 (10.9% vs. 16.9% vs. 18.1%; P < 0.05). For men, we observed no birth-cohort differences in depression, while neuroticism was found to be lower in 2014-16 compared with 1976-77 among men without depression (5.1 vs. 5.9; P < 0.01). The sex difference for MADRS and neuroticism declined between 1976-77 and 2014-16 (cohort*sex P < 0.05). Conclusions: Depressive burden and neuroticism decreased in 70-yearold women between 1976 and 2016.
Significant outcomes• Projections for depression rates in the population are uncertain as the prevalence may change over time and may differ between birth-cohorts. Our results show fluctuating prevalence between 1976 and 2016, however a decrease only statistically significant for women.• Our findings show a decreased sex ratio in depression and neuroticism between 1976 and 2016, suggesting that environmental factors may play a role when contradicting time trend results for men and women are reported among studies.
Limitations• The 1922 birth-cohort only includes women, which limited our ability to investigate time trends in men to the same extent.• Some subgroups in our analyses (e.g., men and women with major depression) were small, which limited the statistical power and may have generated false-negative results.