Age-related alterations in the central thermoregulatory responsiveness to alpha-MSH

Rostás, Ildikó; Füredi, Nóra; Tenk, Judit; Mikó, Alexandra; Solymár, Margit; Soós, Sz; Székely, Miklós; Pétervári, Erika; Balaskó, Márta

doi:10.1016/j.jtherbio.2015.01.004

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…The increase of metabolites of citric acid cycle by α-MSH seems to enhance the energy metabolism. These results may be related to other findings that α-MSH can control body weight through its hypermetabolic and hyperthermic effects [ 24 ]. It is well known that the hypothalamic melanocortin system is involved in thermoregulation [ 25 ].…”

Section: Discussionsupporting

confidence: 81%

Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells

Seo

Kim

et al. 2020

Molecules

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The purpose of this study was to understand the changes of metabolic pathway induced by alpha-melanocyte-stimulating hormone (α-MSH) in B16F10 melanoma cells in an untargeted metabolomics approach. Cells were treated with 100 nM of α-MSH and then incubated for 48 h. α-MSH increased tyrosinase activity and melanin content by 56.5 and 61.7%, respectively, compared to untreated cells after 48 h of cultivation. The clear separation between groups was observed in the principal component analysis score plot, indicating that the levels of metabolites of melanoma cells were altered by treatment with α-MSH. Metabolic pathways affected by α-MSH were involved in some amino acid metabolisms. The increased levels of fumaric acid, malic acid, oxaloacetic acid and citric acid related to the citric acid cycle pathway after α-MSH treatment suggested enhanced energy metabolism. Metabolic pathways altered by α-MSH treatment can provide useful information to develop new skin pigmentation inhibitors or anti-obesity drugs.

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Section: Discussionsupporting

confidence: 81%

Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells

Seo

Kim

et al. 2020

Molecules

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“…It is well-known that centrally applied Ucn2 elicits anorexia and hyperthermia [20,[24][25][26] via activation of the central CRH type 2 receptors [21] We hypothesized that the responsiveness to Ucn2 changes during the course of aging, similarly to other catabolic mediators, such as leptin or alpha-MSH [6,7,27,28]. The responsiveness to these mediators decreased in the middle-aged and increased in the old-age groups of laboratory rodents.…”

Section: Discussionmentioning

confidence: 99%

“…We also tested the acute hypermetabolic, hyperthermic effects of centrally applied Ucn2. Mediators that decrease body weight, such as leptin or melanocortin agonist alphamelanocyte-stimulating hormone, not only show anorexigenic effects but also show hypermetabolic effects (as indicated by the increase in oxygen consumption) [6,28]. Such hypermetabolic effects also increase the core temperature.…”

Section: Discussionmentioning

confidence: 99%

Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats

Kovács

Eitmann

Berta

et al. 2023

IJMS

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Middle-aged obesity and aging cachexia present healthcare challenges. Central responsiveness to body-weight-reducing mediators, e.g., to leptin, changes during aging in a way, which may promote middle-aged obesity and aging cachexia. Leptin is connected to urocortin 2 (Ucn2), an anorexigenic and hypermetabolic member of the corticotropin family. We aimed to study the role of Ucn2 in middle-aged obesity and aging cachexia. The food intake, body weight and hypermetabolic responses (oxygen consumption, core temperature) of male Wistar rats (3, 6, 12 and 18 months) were tested following intracerebroventricular injections of Ucn2. Following one central injection, Ucn2-induced anorexia lasted for 9 days in the 3-month, 14 days in the 6-month and 2 days in the 18-month group. Middle-aged 12-month rats failed to show anorexia or weight loss. Weight loss was transient (4 days) in the 3-month, 14 days in the 6-month and slight but long-lasting in the 18-month rats. Ucn2-induced hypermetabolism and hyperthermia increased with aging. The age-dependent changes in the mRNA expression of Ucn2 detected by RNAscope in the paraventricular nucleus correlated with the anorexigenic responsiveness. Our results show that age-dependent changes in Ucn2 may contribute to middle-aged obesity and aging cachexia. Ucn2 shows potential in the prevention of middle-aged obesity.

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“…In a fed state, the leptin levels suppress NPY and AgRP neurons, stimulate a POMC, and consequently α-MSH [1, 2]. Besides the function of energy balance control by anorexigenic/orexigenic axis, both neuropeptides also affect the metabolism profile acting in the physiology of adipose tissue: NPY affects the adipogenesis and α-MSH is responsible for lipolysis [4, 10, 16]. …”

Section: Discussionmentioning

confidence: 99%

The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

et al. 2018

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Background: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents. Methods: One hundred ten post-pubertal obese adolescents (body mass index >95th percentile) were submitted to 1 year of interdisciplinary therapy (clinical, nutritional, psychological, physical exercise, and physiotherapy support). Body composition and plasma levels of α-MSH, neuropeptide Y (NPY), melanin-concentrating hormone, and agouti-related peptide (AgRP) were measured before and after therapy. The volunteers were grouped on the basis of Tertiles of α-MSH concentration: Low (<0.75 ng/mL), Medium (≤0.76 to ≥1.57 ng/mL), and High (>1.57 ng/mL). Significance was set as p < 0.05. Results: The treatment promoted a significant improvement in body adiposity and fat free mass for all groups. It is important to note that only in the high α-MSH group, a significant increase of the α-MSH/NPY ratio and decrease NPY/AgRP ratio post treatment were observed. Conclusion: The high α-MSH concentration promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents following long-term weight loss therapy and this is important in clinical practice.

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Age-related alterations in the central thermoregulatory responsiveness to alpha-MSH

Cited by 14 publications

References 24 publications

Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells

Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells

Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats

The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

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