Age-Related Changes in Gut Microbiota Alter Phenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility

Becker, Laren; Spear, Estelle; Sinha, S.; Haileselassie, Yeneneh; Habtezion, Aida

doi:10.1016/j.jcmgh.2018.09.001

Cited by 24 publications

(19 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, recent studies have evidenced that alterations in BAs metabolism accompany these aging-associated microbiota shifts and health decline. For instance, increased fecal excretion of deconjugated BAs has been observed in old mice in association with a shift toward pro-inflammatory states in the gut ( Becker et al, 2019 ). In addition, a reduction in cholic acid and an increase in secondary BAs have been noticed in the serum of patients with Alzheimer disease (AD) ( MahmoudianDehkordi et al, 2019 ), presumably reflecting augmented 7α-dehydroxylase activity in the gut microbiota.…”

Section: Bacterial Bile Metabolism: Implications On Health and Diseasmentioning

confidence: 99%

Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology

et al. 2019

View full text Add to dashboard Cite

Bile is a biological fluid synthesized in the liver, mainly constituted by bile acids and cholesterol, which functions as a biological detergent that emulsifies and solubilizes lipids, thereby playing an essential role in fat digestion. Besides, bile acids are important signaling molecules that regulate key functions at intestinal and systemic levels in the human body, affecting glucose and lipid metabolism, and immune homeostasis. Apart from this, due to their amphipathic nature, bile acids are toxic for bacterial cells and, thus, exert a strong selective pressure on the microbial populations inhabiting the human gut, decisively shaping the microbial profiles of our gut microbiota, which has been recognized as a metabolic organ playing a pivotal role in host health. Remarkably, bacteria in our gut also display a range of enzymatic activities capable of acting on bile acids and, to a lesser extent, cholesterol. These activities can have a direct impact on host physiology as they influence the composition of the intestinal and circulating bile acid pool in the host, affecting bile homeostasis. Given that bile acids are important signaling molecules in the human body, changes in the microbiota-residing bile biotransformation ability can significantly impact host physiology and health status. Elucidating ways to fine-tune microbiota-bile acids-host interplay are promising strategies to act on bile and cholesterol-related disorders. This manuscript summarizes the current knowledge on bile and cholesterol metabolism by intestinal bacteria, as well as its influence on host physiology, identifying knowledge gaps and opportunities to guide further advances in the field.

show abstract

Section: Bacterial Bile Metabolism: Implications On Health and Diseasmentioning

confidence: 99%

Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This resulted in a phenotypic switch of mMac to a more pro-inflammatory state, stimulating low-grade inflammation in these tissues and thus delayed GI transit. (237). The microbiome-BA balance and its role in intestinal motility seem an obvious consideration when trying to understand complex treatment strategies such as fecal transplants (235).…”

Section: Bile Acids and Intestinal Motility Disordersmentioning

confidence: 99%

Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels

Keely

Urso

Ilyaskin

et al. 2022

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

BAs are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades, significant advances in identifying and characterizing the receptors, transporters, and ion channels targeted by bile acids (BAs) has led to exciting new insights into the molecular mechanisms involved in these processes. Our appreciation of BAs, their receptors and BA-modulated ion channels as potential targets for the development of new approaches to treat intestinal motility and transport disorders is increasing. In the current review, we aim to summarize recent advances in our knowledge of the different BA receptors and BA-modulated ion channels present in the gastrointestinal system. We discuss how they regulate motility and epithelial transport, their roles in pathogenesis and their therapeutic potential in a range of gastrointestinal diseases.

show abstract

“…A reduced number of anti-inflammatory MMs in aged mice is linked to EN loss. 60 , 61 In another report, the investigators tested the association of MMs with ENs during development using a double-transgenic zebrafish model. This study provided evidence of the intimate proximity between MMs and ENs starting at 3 days after fertilization.…”

Section: Proximity Defines Functionalitymentioning

confidence: 99%

Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease

Mischopoulou

D’Ambrosio

Bigagli

et al. 2022

Cellular and Molecular Gastroenterology and Hepatology

View full text Add to dashboard Cite

Age-Related Changes in Gut Microbiota Alter Phenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility

Cited by 24 publications

References 16 publications

Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology

Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology

Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels

Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease

Contact Info

Product

Resources

About