Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Albouery, Mayssa; Buteau, Bénédicte; Grégoire, Stéphane; Cherbuy, Claire; Barros, Jean‐Paul Pais de; Martine, Lucy; Chain, Florian; Cabaret, Stéphanie; Berdeaux, Olivier; Bron, Alain M.; Acar, Niyazi; Langella, Philippe; Bringer, Marie-Agnès

doi:10.3389/fcimb.2019.00444

Cited by 59 publications

(42 citation statements)

References 79 publications

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“…In summary, the HF/TFA-rich diets could induce obesity, adverse serum parameters, modifications of lipid profiles in the brain and plasma and gut dysbiosis. Based on the hypotheses of Mohammed et al (24) and Albouery et al (26) , we speculated that dietary TFA might lead to modifications of insulin level in the serum and lipid profiles in the brain and plasma through the gut microbiota. All of the results demonstrated links between the HF/TFA-DIO and dysfunction of the gut microbiota, including adverse blood and brain parameters, an increase in Bacteroidetes, a decrease in Muribaculaceae, etc.…”

Section: Resultsmentioning

confidence: 98%

“…The results of Phivilay et al (25) support this phenomenon, indicating that most TFA are produced at the expense of decreases in linoleic acid. In addition, Albouery et al (26) pointed out that intestinal colonisation by a microbiota profoundly modified the brain lipid composition. Our study showed that TFA could lead to modifications of lipid profiles in the brain and plasma.…”

Section: Discussionmentioning

confidence: 99%

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Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats

et al. 2020

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The gut microbiota is directly influenced by dietary components, and it plays critical roles in chronic diseases. Excessive consumption of trans fatty acids (TFAs) is associated with obesity induced by alterations in gut microbiota, but the links between obesity and gut microbiota remain unclear. Therefore, studies examining the impact of TFAs on intestinal microflora are essential. In our study, we performed 16S rRNA gene sequencing on faecal samples from SD rats fed a basal diet (CON group), high-fat (HF) diet (DIO group) or TFA diets (1% TFA group and 8% TFA group) for 8 weeks to investigate the effects of TFA/HF diets on obesity and gut microbiota composition. We found that the TFAs/HF diets significantly induced obesity and changes in blood and brain physiological parameters of the rats. The relative abundance of the phyla Firmicutes and Bacteroidetes were inversely altered in the three test groups compared to the CON group. Proteobacteria increased slightly in the DIO, 1% TFA and 8% TFA groups. The genus Bacteroides increased in the DIO and 1% TFA groups, but Muribaculaceae decreased in all experimental groups compared to the controls. Moreover, significant differences were observed among clusters of orthologous group (COG) functional categories of the four dietary groups. Our observations suggested that the TFA/HF diets induced obesity and dysfunction of gut microbiota. Gut dysbiosis might mediate the obesity effects of TFA/HF diets.

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats

et al. 2020

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“…Animal studies also posit that gut microbes can modulate the host’s lipidome. For instance, Albouery et al investigated how colonization of germ-free (GF) mice by the fecal microbiota of young or old donor mice impacted the lipid content of the brain and liver [ 12 ]. Mice receiving fecal bacteria from aged mice exhibited increased total monounsaturated fatty acids, and a reduction in the relative amounts of cholesterol and total polyunsaturated fatty acids in the brain cortex.…”

Section: Lipid Pool Of the Human Gutmentioning

confidence: 99%

Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations

et al. 2021

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Various studies aiming to elucidate the role of the gut microbiome-metabolome co-axis in health and disease have primarily focused on water-soluble polar metabolites, whilst non-polar microbial lipids have received less attention. The concept of microbiota-dependent lipid biotransformation is over a century old. However, only recently, several studies have shown how microbial lipids alter intestinal and circulating lipid concentrations in the host, thus impacting human lipid homeostasis. There is emerging evidence that gut microbial communities play a particularly significant role in the regulation of host cholesterol and sphingolipid homeostasis. Here, we review and discuss recent research focusing on microbe-host-lipid co-metabolism. We also discuss the interplay of human gut microbiota and molecular lipids entering host systemic circulation, and its role in health and disease.

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“…The genomic DNA of gut microbiota was extracted from murine cecal contents, and 16S rRNA genes in the DNA samples were analyzed using a MiSeq sequencer (Illumina, San Diego, CA, USA) Microbiome analysis were performed by Biomnigene company (www.biomnigene.fr, Besançon, France), as previously reported [36]. Briefly, microbial genomic DNA was extracted using the E.Z.N.A Stool DNA kit (Omega Bio-tek, Norcross, GA, USA) following the manufacturer's instructions.…”

Section: Fecal Microbiota Analysis By 16s Rrna Gene Sequencingmentioning

confidence: 99%

Effects of Fecal Microbiota Transplantation on Composition in Mice with CKD

Barba

Soulage

Caggiano

et al. 2020

Toxins

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Background: Chronic kidney disease (CKD) is a renal disorder characterized by the accumulation of uremic toxins with limited strategies to reduce their concentrations. A large amount of data supports the pivotal role of intestinal microbiota in CKD complications and as a major source of uremic toxins production. Here, we explored whether fecal microbiota transplantation (FMT) could be attenuated in metabolic complication and uremic toxin accumulation in mice with CKD. Methods: Kidney failure was chemically induced by a diet containing 0.25% (w/w) of adenine for four weeks. Mice were randomized into three groups: control, CKD and CKD + FMT groups. After four weeks, CKD mice underwent fecal microbiota transplantation (FMT) from healthy mice or phosphate buffered saline as control. The gut microbiota structure, uremic toxins plasmatic concentrations, and metabolic profiles were explored three weeks after transplantation. Results: Associated with the increase of alpha diversity, we observed a noticeable improvement of gut microbiota disturbance, after FMT treatment. FMT further decreased p-cresyl sulfate accumulation and improved glucose tolerance. There was no change in kidney function. Conclusions: These data indicate that FMT limited the accumulation of uremic toxins issued from intestinal cresol pathway by a beneficial effect on gut microbiota diversity. Further studies are needed to investigate the FMT efficiency, the timing and feces amount for the transplantation before, to become a therapeutic option in CKD patients.

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Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Cited by 59 publications

References 79 publications

Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats

Trans-fatty acids alter the gut microbiota in high-fat-diet-induced obese rats

Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations

Effects of Fecal Microbiota Transplantation on Composition in Mice with CKD

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