Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women

Kawabata, Takeshi; Hirota, Satoko; Hirayama, Tomoko; Adachi, Naoko; Hagiwara, Chie; Iwama, Noriko; Kamachi, Keiko; Araki, Eiji; Kawashima, Hiroshi; Kiso, Yoshinobu

doi:10.1016/j.plefa.2011.01.001

Cited by 44 publications

(36 citation statements)

References 32 publications

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“…Younger and middle-aged individuals consume less seafood and more meat than the elderly [14]. Blood FA levels are associated with habitual dietary fat intake [15]; hence, we hypothesized that younger Japanese would have lower serum DHA and EPA levels derived from lower FA intake compared with the elderly, as well as higher serum ARA levels affected by higher ARA intake contained in meat and eggs (a westernized diet) [16]. However, our 13-year nutritional data in this study did not suggest any increased trend in ARA.…”

Section: Discussionmentioning

confidence: 99%

Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese—A 4- and 13-year descriptive epidemiologic study

Otsuka

Kato

Imai

et al. 2015

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Discussionmentioning

confidence: 99%

Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese—A 4- and 13-year descriptive epidemiologic study

Otsuka

Kato

Imai

et al. 2015

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

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SummaryClinical features and outcomes of acute myocardial infarction (AMI) in the young have been poorly investigated. The aim of this study was to investigate the clinical features and hospital outcomes of AMI in young Japanese. We conducted a case-control study. A total of 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group and 106 AMI patients whose age was > 45 years old were assigned to the non-young group. We compared the clinical features and hospital outcomes between the two groups. Compared with the non-young group, the young group was associated with male sex, hyperlipidemia, current smoking, being overweight, single vessel disease, and Killip class I on admission. There were no differences in the length of hospital stay or major adverse cardiac events between the groups. However, mortality and ventricular rupture were slightly lower in the young. In conclusion, young AMI patients had clinical characteristics different to those of the non-young patients. Compared to non-young patients, modifiable risk factors such as smoking, hyperlipidemia, and being overweight were associated with young AMI patients. (Int Heart J 2013; 54: 123-128) Key words: Angioplasty, Age, Ischemic heart disease A lthough the incidence of coronary artery disease in the young is still lower than that in the non-young, 1,2) coronary artery disease in the young has been increased recently. The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients. We conducted a case-control study to elucidate the clinical features of AMI in young patients. MethodsCases and controls: We identified acute myocardial infarction patients from the hospital records of our medical center from January 2007 to March 2012. A diagnosis of AMI consisted of elevation of creatine kinase (at least 2-fold above the normal upper limit), and the presence of 1 of the following 2 criteria; (1) persistent chest pain or (2) ST-segment elevation or depression in the 12-lead electrocardiogram compatible with AMI. During the study period, 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group (Case group). 8,12) The control patients were selected from our AMI patients whose age was > 45 years old during the same study period. We designed the study so the ratio of cases to controls would be 1 to 2. To minimize the selection bias, consecutive AMI patients whose age was > 45 years old were assigned to the non-young group (Control group). In addition, to minimize any bias related to the therapeutic strategy for AMI, consecutive selection was conducted for each year. This study was approved by the institutional review board. PCI procedures: PCI was p...

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“…Japanese people habitually eat fish and shellfish that are rich in n-3 PUFAs including DHA [6,7]. According to the National Health and Nutritional Survey of Japan [6], the mean intake of fish and shellfish by adults aged 20 years and over was 81.7 g/day for men and 67.8 g/day for women.…”

Section: Introductionmentioning

confidence: 99%

“…According to the National Health and Nutritional Survey of Japan [6], the mean intake of fish and shellfish by adults aged 20 years and over was 81.7 g/day for men and 67.8 g/day for women. In the dietary records, together with photographic records of 28 consecutive days, we have previously demonstrated that the mean fish intake of young women of about 20 years of age was 42.8 g/day, and the DHA composition of erythrocyte phospholipids measured simultaneously was 6.1% [7]. In addition, it has been reported that the erythrocyte DHA composition in Japanese people was 7.0% in less than 35-year-old males [8], 6.4% in 20 to 60-year-old women [9], and 7.9% in middle-aged men and women [10].…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth

et al. 2017

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Background: The transport of polyunsaturated fatty acids (PUFAs), such as arachidonic acid (ARA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), to the fetus from maternal stores increases depending on the fetal requirements for PUFA during the last trimester of pregnancy. Therefore, maternal blood PUFA changes physiologically with gestational age. However, the changes in PUFA levels in maternal blood erythrocytes during pregnancy and after childbirth have not been fully investigated in a fish-eating population. Objective: To examine the changes of ARA and DHA levels in maternal erythrocytes with the progress of pregnancy and the relationship between maternal and umbilical cord erythrocyte PUFA levels in pregnant Japanese women who habitually eat fish and shellfish. Design: This study was performed as a part of the adjunct study of the Japan Environment and Children’s Study (JECS). The participants were 74 pregnant women. The maternal blood samples were collected at 27, 30, and 36 weeks of pregnancy, and 2 days and 1 month after delivery, and umbilical cord blood was collected at delivery. The fatty acid levels of erythrocytes in these blood samples were determined. Results: ARA and DHA levels in maternal erythrocytes tended to decrease with the progress of pregnancy. While the DHA level decreased further after delivery, the ARA level returned to the value at 27 weeks of pregnancy within 1 month after delivery. The n-3 and n-6 PUFA levels in maternal erythrocytes at 27, 30, and 36 weeks of pregnancy were significantly positively correlated with the corresponding fatty acid levels in umbilical cord erythrocytes. Conclusion: The present findings showed a significant change in erythrocyte PUFA levels during pregnancy and after childbirth in a fish-eating population. The PUFA levels of maternal blood after the second trimester may be a reliable marker for predicting PUFA levels in infants’ circulating blood.

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Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women

Cited by 44 publications

References 32 publications

Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese—A 4- and 13-year descriptive epidemiologic study

Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese—A 4- and 13-year descriptive epidemiologic study

Clinical Features of Myocardial Infarction in Young Japanese Patients

Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth

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