Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese—A 4- and 13-year descriptive epidemiologic study
“…These observations are in line with the results from comparison of medians from the Bonferroni corrected WMW-tests discussed above. The observed age-related increase in absolute DHA and EPA concentrations complies with other investigations published recently (Risé et al 2013 ; Otsuka et al 2013 , 2015 ; Harris et al 2013 ). Fig.…”
Section: Resultssupporting
confidence: 92%
“…These are the same FAs that dominated the model comparing children with adults except that DPA seems to increase more than EPA and DHA with age in the adult female cohort. Our conclusions complies with results from previous investigations using univariate statistics to test for age-related changes in EPA, DHA and EPA/AA (Otsuka et al 2013 , 2015 ; Harris et al 2013 ; Risé et al 2013 ), Fig. 2 SR plot displaying changes in fatty acid pattern during aging for women.…”
Section: Resultssupporting
confidence: 91%
“…They observed changes in relative levels of EPA and DHA in blood from child to adult and to elderly in both genders. Otsuka et al ( 2013 , 2015 ) independently found positive correlations between age and absolute concentrations of EPA and DHA in adults aged 40–79 years. Harris et al ( 2013 ) analyzed red blood cells of 160,000 patients that were examined for cardiovascular (CV) risk factors and observed an increase in relative concentrations of EPA and DHA.…”
Concentrations in serum were determined for 18 fatty acids (FAs) and 21 lipoprotein main and subclasses by chromatographic analyses and the average size was calculated for very low density (VLDL), low density (LDL) and high density (HDL) particles. 283 ethnic Norwegian children and adults from the rural Fjord region of Western Norway were compared with the objectives to reveal patterns and gender differences during the development from prepuberty to adulthood and during aging in adults. Both genders showed a large increase in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from child to adult. Males, but not females, show a significant increase in most C16–C18 FAs from prepuberty to adulthood. These changes in males correlate to a pattern of increased concentrations of triglycerides, VLDL and LDL particles, especially the atherogenic subclasses of small and very small LDL particles. Furthermore, concentrations of medium, large and very large HDL particles decrease, while concentration of very small HDL particles increase leading to reduced average size of HDL particles. Females only showed significant increase in concentrations of small and very small LDL particles, very small HDL particles and apolipoprotein B. While EPA and DHA continued to increase during aging in women, no validated model for connecting age to FA profile was obtained for men. Women showed significant increase in concentrations of all subclasses of LDL particles during aging, while men exhibited a more complex pattern with increase also in apolipoprotein A1 and HDL particles.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-016-0968-y) contains supplementary material, which is available to authorized users.
“…These observations are in line with the results from comparison of medians from the Bonferroni corrected WMW-tests discussed above. The observed age-related increase in absolute DHA and EPA concentrations complies with other investigations published recently (Risé et al 2013 ; Otsuka et al 2013 , 2015 ; Harris et al 2013 ). Fig.…”
Section: Resultssupporting
confidence: 92%
“…These are the same FAs that dominated the model comparing children with adults except that DPA seems to increase more than EPA and DHA with age in the adult female cohort. Our conclusions complies with results from previous investigations using univariate statistics to test for age-related changes in EPA, DHA and EPA/AA (Otsuka et al 2013 , 2015 ; Harris et al 2013 ; Risé et al 2013 ), Fig. 2 SR plot displaying changes in fatty acid pattern during aging for women.…”
Section: Resultssupporting
confidence: 91%
“…They observed changes in relative levels of EPA and DHA in blood from child to adult and to elderly in both genders. Otsuka et al ( 2013 , 2015 ) independently found positive correlations between age and absolute concentrations of EPA and DHA in adults aged 40–79 years. Harris et al ( 2013 ) analyzed red blood cells of 160,000 patients that were examined for cardiovascular (CV) risk factors and observed an increase in relative concentrations of EPA and DHA.…”
Concentrations in serum were determined for 18 fatty acids (FAs) and 21 lipoprotein main and subclasses by chromatographic analyses and the average size was calculated for very low density (VLDL), low density (LDL) and high density (HDL) particles. 283 ethnic Norwegian children and adults from the rural Fjord region of Western Norway were compared with the objectives to reveal patterns and gender differences during the development from prepuberty to adulthood and during aging in adults. Both genders showed a large increase in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from child to adult. Males, but not females, show a significant increase in most C16–C18 FAs from prepuberty to adulthood. These changes in males correlate to a pattern of increased concentrations of triglycerides, VLDL and LDL particles, especially the atherogenic subclasses of small and very small LDL particles. Furthermore, concentrations of medium, large and very large HDL particles decrease, while concentration of very small HDL particles increase leading to reduced average size of HDL particles. Females only showed significant increase in concentrations of small and very small LDL particles, very small HDL particles and apolipoprotein B. While EPA and DHA continued to increase during aging in women, no validated model for connecting age to FA profile was obtained for men. Women showed significant increase in concentrations of all subclasses of LDL particles during aging, while men exhibited a more complex pattern with increase also in apolipoprotein A1 and HDL particles.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-016-0968-y) contains supplementary material, which is available to authorized users.
“…There were revealed significantly higher levels of individual ω6 and saturated FA in subgroup 3: γ-linolenic FA (γ-18:3, 16.50±2 vs. 10.80±1.10 µg/ml, p=0.02), digomo-γ-linolenic (γ-20: 3 Patients aged 41 to 45 have significantly lower levels of stearic (18:0), γ-linolenic (γ-18:3) and digomo-γ-linolenic FA (γ-20:3) compared to those in subgroups 3-6 (see Table 2). According to the data of another Japanese study, the concentration of arachidonic acid in blood serum increased during 4 years in both men and women aged 40-69, even after adjusting of intake of arachidonic acid [13]. Higher levels of DHA and lower EPA levels in young women are consistent with an elevated conversion of EPA to DHA during the reproductive age [14].…”
Section: Resultsmentioning
confidence: 92%
“…They have shown an increase in the levels of EPA and DHA, starting with childhood, among adults and the elderly, among both genders. Otsuka with the co-authors [12,13] found a positive correlation between age and absolute concentrations of EPA and DHA among adults aged 40-79 years. Harris with the co-authors [14] analyzed the state of erythrocytes among 160 000 patients who were determined CVR and found an increase in relative levels of EPA and DHA.…”
The objective of the study – is to identify the age peculiarities of the fat-acidic and lipid blood plasma spectrum in the inhabitants of the plain settlements of the Transcarpathian region with overweight and obesity.
Materials and methods. There were examined 107 persons, who applied for the assistance to the Family Medicine Outpatient Clinic №7 in Uzhgorod. The examined persons were estimated the following data: age, gender, BMI, waist circumference, lipid and fat-acidic spectrum.
Results of the study. The study involved 74 women (69.1%) and 33 men (30.9%). The average age of the examined persons was 52.4±1.0 years. The BMI of the examined patients was 27.5±0.4 kg/m2, and the waist circumference was – 92.4±1.6 cm. All patients were divided into 6 age groups with intervals of 5 years, starting with 40 years. Starting from the 46 years and older, in each age group, there was a significantly higher BMI compared to persons under 40 years of age. In the examined persons over 40 years the changes of the lipid spectrum in the direction of growth of atherogenic fractions were observed.
Beginning from the age of 46 years, the levels of total ω6-PUFA and ω3-PUFA are significantly higher compared to persons aged under 40 years. In individuals aged under 50 years there is an increase of average levels of PUFA, therefore the highest growth of ω3-PUFAs is observed in the period from 40 to 50 years of age (from 60.10±5.50 μg/ml to 102.9±5.20 μg/ml, p< 0.01), and of ω6-PUFA in the period from 45 to 50 years (from 1288.10±62.40 μg/ml to 1501.10±67.50 μg/ml; p=0.03).
Conclusions. There is a shift in the lipid spectrum, which corresponds to atherogenic dyslipidemia, in the examined persons aged over 40 years. In individuals aged under 50 years there is an increase in total levels of PUFA, thus the highest growth of ω3-PUFA is observed in the period from 40 to 50 years, and ω6- PUFA in the period from 45 to 50 years. The stabilization of the fatty acids composition was revealed in persons aged 50 years and more.
Objectives To analyze in detail the fatty acid (FA) composition of follicular fluid (FF) from two-sized follicles at oocyte retrieval and to determine associations of the FAs from large follicles with the woman's age and the response to ovarian stimulation. Design Observational study. Setting University and fertility clinic. Patients Sixty-four women (age 19-46), consisting of unfertile patients and oocyte donors, undergoing controlled ovarian stimulation. Interventions None. Main outcome measure(s) FF from small (< 12 mm) and large (≥ 18 mm) follicles was collected at oocyte retrieval. FAs by gas chromatography-flame ionization detection. Result Thirty-two FAs with chain lengths ranging from 14 to 25 carbons were identified. There was a readjustment in FA distribution as follicle size increased, raising very long-chain saturated FAs, nervonic (24:1n-9), arachidonic (20:4n-6), and n-3 polyunsaturated FAs (PUFA, P < 0.001), the latter mainly due to an increase in docosahexaenoic acid (22:6n-3, DHA). In large follicles, double bond and peroxidizability indices and total n-3 PUFA, particularly DHA, correlated positively with the woman's age and negatively with the number of total and mature oocytes, total and top-quality embryos, and fertilization rate. Conclusions We have described 32 FAs in ovarian FF, of which 16 changed their distribution with follicle size. The results also indicate that lower n-3 PUFA levels in large follicles, which are associated with younger women, predict a better response to ovarian stimulation based on the recovery of total and mature oocytes, total and top-quality embryos, and fertilization rate per cycle. Key message The fatty acid profile of ovarian FF changes as the follicle grows and lower n-3 PUFA levels in large follicles, associated with younger women, predict a better response to ovarian stimulation.
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