Age-related changes of the human retinal vessels: Possible involvement of lipid peroxidation

Nag, Tapas Chandra; Maurya, Manish Kumar; Roy, Tara Sankar

doi:10.1016/j.aanat.2019.06.007

Cited by 16 publications

(9 citation statements)

References 51 publications

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“…Severer oxidative damage was also found in the aortic media of older people (162). In human retinal vessels, aging induces the partial degeneration and loss of VSMCs and exacerbates oxidative stress (169,203). In rodent studies, the aortic tissues from aged mice exhibit mitochondrial dysfunction, and both cellular and mitochondrial levels of ROS are elevated in aortic tissues and VSMCs from aged mice (237,243).…”

Section: Other Factors Associated With Vascular Diseasementioning

confidence: 99%

Metabolism of vascular smooth muscle cells in vascular diseases

Shi

Yang

Cheng

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

218

120

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Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer of arteries and are essential for arterial physiology and pathology. It is becoming increasingly clear that VSMCs can alter their metabolism to fulfill the bio-energetic and biosynthetic requirements. During vascular injury, VSMCs switch from a quiescent "contractile" phenotype to a highly migratory and proliferative "synthetic" phenotype. Recent studies find that the phenotype switching of VSMCs is driven by a metabolic switch. Metabolic pathways, including aerobic glycolysis, fatty acid oxidation, and amino acid metabolism, have distinct, indispensable roles in normal and dysfunctional vasculature. VSMCs metabolism is also related to the metabolism of endothelial cells. In the present review, we present a brief overview of VSMCs metabolism, and how it regulates the progression of several vascular diseases, including atherosclerosis, systemic hypertension, diabetes, pulmonary hypertension, vascular calcification, and aneurysms, and the effect of the risk factors for vascular disease (aging, cigarette smoking and excessive alcohol drinking) on VSMCs metabolism, to clarify the role of VSMCs metabolism in the key pathological process.

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Section: Other Factors Associated With Vascular Diseasementioning

confidence: 99%

Metabolism of vascular smooth muscle cells in vascular diseases

Shi

Yang

Cheng

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

218

120

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“…The aging process of the human retina often triggers oxidative stress reactions, inducing significant alterations within the retina [91]. Nag et al investigated changes in retinal blood vessels across various age groups using light and transmission electron microscopy, TUNEL, and immunohistochemistry [92]. The analysis encompassed vascular smooth muscle cells, oxidative stress, microglia, and blood vessels to evaluate the extent of human retinal aging.…”

Section: Retinal Vascular Aging: Pathophysiologymentioning

confidence: 99%

Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress

Cui,

Buonfiglio,

Pfeiffer

et al. 2024

Biomedicines

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Acknowledged as a significant pathogenetic driver for numerous diseases, aging has become a focal point in addressing the profound changes associated with increasing human life expectancy, posing a critical concern for global public health. Emerging evidence suggests that factors influencing vascular aging extend their impact to choroidal and retinal blood vessels. The objective of this work is to provide a comprehensive overview of the impact of vascular aging on ocular blood vessels and related diseases. Additionally, this study aims to illuminate molecular insights contributing to vascular cell aging, with a particular emphasis on the choroid and retina. Moreover, innovative molecular targets operating within the domain of ocular vascular aging are presented and discussed.

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“…Lysosomes become incapable of completely breaking down all oxidized products of photoreceptor metabolism. This leads to the ferritin-mediated formation and accumulation of iron and non-degradable LF pigment in RPE lysosomes [39,66]. At the same time, LF can occupy The excessive accumulation of advanced glycation end products enhances the sensitivity of the RPE to pro-inflammatory stimuli, activates the transcription factor NF-κB, and leads to pathological ECM remodeling [82].…”

Section: Functional Prerequisite Of Rpe Cells For Oxidative Stressmentioning

confidence: 99%

“…Lysosomes become incapable of completely breaking down all oxidized products of photoreceptor metabolism. This leads to the ferritin-mediated formation and accumulation of iron and non-degradable LF pigment in RPE lysosomes [ 39 , 66 ]. At the same time, LF can occupy up to 25% of the volume of RPE cells, causing residual molecular components to accumulate in the cytoplasm and impairing their export through the plasma membrane [ 67 ].…”

Section: Functional Prerequisite Of Rpe Cells For Oxidative Stressmentioning

confidence: 99%

Endogenous and Exogenous Regulation of Redox Homeostasis in Retinal Pigment Epithelium Cells: An Updated Antioxidant Perspective

Markitantova

Симирский

2023

IJMS

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The retinal pigment epithelium (RPE) performs a range of necessary functions within the neural layers of the retina and helps ensure vision. The regulation of pro-oxidative and antioxidant processes is the basis for maintaining RPE homeostasis and preventing retinal degenerative processes. Long-term stable changes in the redox balance under the influence of endogenous or exogenous factors can lead to oxidative stress (OS) and the development of a number of retinal pathologies associated with RPE dysfunction, and can eventually lead to vision loss. Reparative autophagy, ubiquitin–proteasome utilization, the repair of damaged proteins, and the maintenance of their conformational structure are important interrelated mechanisms of the endogenous defense system that protects against oxidative damage. Antioxidant protection of RPE cells is realized as a result of the activity of specific transcription factors, a large group of enzymes, chaperone proteins, etc., which form many signaling pathways in the RPE and the retina. Here, we discuss the role of the key components of the antioxidant defense system (ADS) in the cellular response of the RPE against OS. Understanding the role and interactions of OS mediators and the components of the ADS contributes to the formation of ideas about the subtle mechanisms in the regulation of RPE cellular functions and prospects for experimental approaches to restore RPE functions.

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Age-related changes of the human retinal vessels: Possible involvement of lipid peroxidation

Cited by 16 publications

References 51 publications

Metabolism of vascular smooth muscle cells in vascular diseases

Metabolism of vascular smooth muscle cells in vascular diseases

Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress

Endogenous and Exogenous Regulation of Redox Homeostasis in Retinal Pigment Epithelium Cells: An Updated Antioxidant Perspective

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