2020
DOI: 10.1167/iovs.61.4.11
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Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens

Abstract: Purpose Studying the full shape crystalline lens geometry is important to understand the changes undergone by the crystalline lens leading to presbyopia, cataract, or failure of emmetropization, and to aid in the design and selection of intraocular lenses and new strategies for correction. We used custom-developed three-dimensional (3-D) quantitative optical coherence tomography (OCT) to study age-related changes in the full shape of the isolated human crystalline lens. Methods … Show more

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Cited by 36 publications
(32 citation statements)
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“…The same group of researchers analyzed crystalline lens geometry and ocular biometry as a function of age, refractive error, AL, and accommodation. 21,27,28,31 They reported a biphasic behavior of LT and LD, with an increase in LD and a decrease in LT before age 20 and a slower linear growth in both parameters thereafter. 28 In addition, they observed a rapid increase in LV in early childhood, a plateau between 10 and 20 years, and a linear increase thereafter.…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
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“…The same group of researchers analyzed crystalline lens geometry and ocular biometry as a function of age, refractive error, AL, and accommodation. 21,27,28,31 They reported a biphasic behavior of LT and LD, with an increase in LD and a decrease in LT before age 20 and a slower linear growth in both parameters thereafter. 28 In addition, they observed a rapid increase in LV in early childhood, a plateau between 10 and 20 years, and a linear increase thereafter.…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
“…21,27,28,31 They reported a biphasic behavior of LT and LD, with an increase in LD and a decrease in LT before age 20 and a slower linear growth in both parameters thereafter. 28 In addition, they observed a rapid increase in LV in early childhood, a plateau between 10 and 20 years, and a linear increase thereafter. In long, myopic eyes, the lens was found to expand equatorially, but get thinner antero-posteriorly; as such, lenses of long eyes did not appear to gain in volume.…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
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“…As described earlier, the steps comprised image segmentation, fan and optical distortion correction, tilt removal and registration. In brief, the contour of the lens was first automatically detected from the edge in three different orientations using a custom-developed algorithm (Martinez-Enriquez et al, 2017;2020a;2020b). Both J o u r n a l P r e -p r o o f anterior-up and posterior-up images were corrected for fan and optical distortions caused due to the preservation media (using n = 1.345 as the group refractive index of BSS at 880 nm and DMEM at 840 nm) (Pérez-Merino et al, 2015).…”
Section: Oct Image Processing For 3-d Eye Models Construction and Quantificationmentioning
confidence: 99%
“…Regarding the crystalline lens, on the one hand, phakometry, 6 Scheimpflug imaging, 7 10 magnetic resonance imaging, 11 and optical coherence tomography 12 , 13 have been used to assess the in vivo optical properties of lens shape and lens thickness. On the other hand, in vitro techniques 14 18 have also been followed to evaluate lens shape and power.…”
Section: Introductionmentioning
confidence: 99%