Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle

Ueda, Seinosuke; Aikawa, Masuo; Ishizuya‐Oka, Atsuko; Yamaoka, Sadao; Koibuchi, Noriyuki; Yoshimoto, Kanji

doi:10.1016/s0306-4522(99)00451-0

Cited by 35 publications

(32 citation statements)

References 44 publications

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“…Such features have already been reported for serotonergic and cholinergic systems in normal, aging rats [7,110,77,3], as well as in the entire monoaminergic system of Zitter mutant or microenchephalic rats [106,114]. Enlarged/swollen varicosities are generated by accumulations of intra-axonal materials as a result of impaired axonal transport due to destabilization of microtubules.…”

Section: Selective Noradrenergic Axonal Degeneration In Sstr2 -/-Brainsmentioning

confidence: 85%

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease

et al. 2015

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Alzheimer's disease and other age-related neurodegenerative disorders are associated with deterioration of the noradrenergic locus coeruleus (LC), a probable trigger for mood and memory dysfunction. LC noradrenergic neurons exhibit particularly high levels of somatostatin binding sites. This is noteworthy since cortical and hypothalamic somatostatin content is reduced in neurodegenerative pathologies. Yet the role of a somatostatin signal-

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Section: Selective Noradrenergic Axonal Degeneration In Sstr2 -/-Brainsmentioning

confidence: 85%

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease

et al. 2015

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“…21 However, because it is present in this brain region only in low concentration, so it was not considered in these analyses. 41 Good fits were obtained for the cyclic voltammograms obtained at later times with those for an acidic change. The utility of the PCR analysis of these data is that it allows separation of these two components throughout the recording interval.…”

Section: Determination Of Dopamine Release From Nerve Terminals In a mentioning

confidence: 99%

Resolving Neurotransmitters Detected by Fast-Scan Cyclic Voltammetry

Johnson²,

2004

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Carbon-fiber microelectrodes are frequently used as chemical sensors in biological preparations. In this work, we evaluated the ability of cyclic voltammograms recorded at fast-scan rates to resolve neurochemicals when analyzed by principal component regression. A calibration set of 30 cyclic voltammograms was constructed from 9 different substances at a variety of concentrations. The set was reduced by principal component analysis, and it was found that 99.5% of the variance in the data could be captured with five principal components. This set was used to evaluate cyclic voltammograms obtained with one or two compounds present in solution. In most cases, satisfactory predictions of the identity and concentration of analytes were obtained. Chemical dynamics were also resolved from a set of fast-scan cyclic voltammograms obtained with the electrode implanted in a region of a brain slice that contains dopaminergic terminals. Following stimulation, principal component regression of the data resolved the changes in dopamine and pH that were evoked. In a second test of the method, vesicular release was measured from adrenal medullary cells and the data were evaluated with a calibration set composed of epinephrine and norepinephrine. Cells that secreted one or the other were identified. Overall, the results show that principal component regression with appropriate calibration data allows resolution of substances that give overlapping cyclic voltammograms.

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“…Atrn deletion-mutant animals (zitter mutant rats) exhibit progressive degeneration of DA neurons in the substantia nigra (SN; Nakadate et al, 2006b;Ueda et al, 2000Ueda et al, , 2002, so the presence of Atrn in DA neurons of the SN was examined. Substantial colocalization of Atrn with TH confirmed that Atrn was highly expressed in the cell soma of DA neurons in SN (Fig.…”

Section: Cellular and Subcellular Localization Of Atrnmentioning

confidence: 99%

“…form degeneration (Bronson et al, 2001;He et al, 2001;Kondo et al, 1991aKondo et al, ,b, 1995Kuramoto et al, 2001;Rehm et al, 1982), and age-related neuronal degeneration (Nakadate et al, 2006b;Ueda et al, 1998Ueda et al, , 2000Ueda et al, , 2002Ueda et al, , 2005. The zitter rat is known as an Attractin/Mahogany mutation animal with an 8-bp deletion at a splice donor site of atrn (Kuramoto et al, 2001).…”

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confidence: 95%

Attractin/mahogany protein expression in the rodent central nervous system

Nakadate

Sakakibara

Ueda

2008

J of Comparative Neurology

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Attractin/Mahogany protein (Atrn) is known to be involved in a number of physiological and neuropathological events. Although the ubiquitous distribution of atrn mRNA has been described in neurons, lack of detailed information concerning the cellular and subcellular localization of protein product is impeding understanding of the role of Atrn. The present study immunohistochemically examined distributions of Atrn in rat and mouse central nervous systems (CNSs) by using a novel antibody for Atrn. Atrn was intensely expressed in most neurons and dendrites of large neurons, such as cortical pyramidal neurons and cerebellar Purkinje neurons. Intense Atrn expression was also observed in the neuropil of gray matter in many regions of the CNS, such as the main and accessory olfactory bulb, cerebral cortex, caudate putamen, dorsal lateral geniculate nucleus, medial eminence, superior colliculus, hippocampus, dentate gyrus, and layers 1 and 2 of the spinal cord. Furthermore, we found that astrocytes, microglia, and ependymal cells also express Atrn protein. Immunoelectron microscopy showed the subcellular distribution of Atrn in the plasma membrane of cell soma, dendrites, and spines in neurons and in the cytoplasmic membrane of Golgi apparatus, endoplasmic reticulum, and mitochondria in neurons and glial cells. These findings indicate that Atrn is more widely expressed throughout the CNS than previously reported, and expression of Atrn by various cell types suggests that Atrn may serve multiple functions in the CNS.

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Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle

Cited by 35 publications

References 44 publications

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease

Resolving Neurotransmitters Detected by Fast-Scan Cyclic Voltammetry

Attractin/mahogany protein expression in the rodent central nervous system

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