Age-Related Effects of Bariatric Surgery on Early Atherosclerosis and Cardiovascular Risk Reduction

Jonker, Frederik H.W.; Houten, Vera A A van; Wijngaarden, Leontine H.; Klaassen, René A.; Smet, A.A.E.A. de; Niezen, André; Schelfhout, L.J.D.M.; Bruning, T. A.; Harst, Erwin van der

doi:10.1007/s11695-017-2962-5

Cited by 21 publications

(17 citation statements)

References 26 publications

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“…Priester et al reported that weight loss achieved through bariatric surgery is associated with less coronary calcification and this effect, which appears to be independent of changes in LDL-C, may contribute to lower cardiac mortality in patients with successful gastric bypass [38]. Additionally, Jonker et al demonstrated that bariatric surgery results in a significant decrease in carotid intima-media thickness in all evaluated age categories, resulting in an improvement of cardiovascular risks [39].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Cardiac Function After Roux-en-Y Gastric Bypass in Morbidly Obese Patients Without Cardiac History Measured by Cardiac MRI

et al. 2020

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Purpose Metabolic syndrome in patients with morbid obesity causes a higher cardiovascular morbidity, eventually leading to left ventricular hypertrophy and decreased left ventricular ejection fraction (LVEF). Roux-en-Y gastric bypass (RYGB) is considered the gold standard modality for treatment of morbid obesity and might even lead to improved cardiac function. Our objective is to investigate whether cardiac function in patients with morbid obesity improves after RYGB. Materials and Methods In this single center pilot study, 15 patients with an uneventful cardiac history who underwent RYGB were included from May 2015 to March 2016. Cardiac function was measured by cardiac magnetic resonance imaging (CMRI), performed preoperatively and 3, 6, and 12 months postoperative. LVEF and myocardial mass and cardiac output were measured. Results A total of 13 patients without decreased LVEF preoperative completed follow-up (mean age 37, 48.0 ± 8.8). There was a significant decrease of cardiac output 12 months postoperative (8.3 ± 1.8 preoperative vs. 6.8 ± 1.8 after 12 months, P = 0.001). Average myocardial mass declined by 15.2% (P < 0.001). After correction for body surface area (BSA), this appeared to be nonsignificant (P = 0.36). There was a significant improvement of LVEF/BSA at 6 and 12 months postoperative (26.2 ± 4.1 preoperative vs. 28.4 ± 3.4 and 29.2 ± 3.6 respectively, both P = 0.002). Additionally, there was a significant improvement of stroke volume/BSA 12 months after surgery (45.8 ± 8.0 vs. 51.9 ± 10.7, P = 0.033). Conclusion RYGB in patients with morbid obesity with uneventful history of cardiac disease leads to improvement of cardiac function.

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Section: Discussionmentioning

confidence: 99%

Improvement of Cardiac Function After Roux-en-Y Gastric Bypass in Morbidly Obese Patients Without Cardiac History Measured by Cardiac MRI

et al. 2020

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“…Of note, lower EAT density and increased EAT volume were associated with coronary calcification, serum levels of plaque inflammatory markers and MACE. That is why it could be a good tool for screening patients undergoing bariatric surgery, facilitating diagnosis of patients who need further treatment [16,17]. Moreover, in a meta-analysis increasing EAT was associated with the presence of high-risk plaque.…”

Section: Discussionmentioning

confidence: 99%

Emerging measurements of atherosclerosis: extra-media thickness, epicardial adipose tissue, and periarterial adipose tissue intima media adventitia index in morbidly obese patients undergoing bariatric surgery.

Domienik‐Karłowicz

Lisik

Kosieradzki

et al. 2019

Videosurgery and Other Miniinvasive Techniques

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Introduction: Increased values of emerging fat indices are correlated with increased cardiovascular risk. Aim: To examine the novel non-invasive predictors of coronary disease, namely the carotid extra-media thickness (EMT), PATIMA, and epicardial adipose tissue (EAT), in a group of patients with morbid obesity. Material and methods: We examined a group of 40 morbidly obese (OB) patients and a control group (CG). All patients were subjected to anthropometric measurements, as well as laboratory and ultrasound examinations.

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“…Anthropometric and CIMT measurements at follow-up Table 2 compares baseline measurements with those obtained at 3-year follow-up in participants who underwent bariatric surgery and in those treated with the nonsurgical approach. In participants treated with bariatric surgery, anthropometric measurements and CVFRs improved significantly; decreases were observed in mean FRS (15 [10][11][12][13][14][15][16] (Figure 1). In participants with obesity treated with the nonsurgical approach, no improvements were observed in BMI, anthropometric measurements, laboratory parameters, CIMT, or 10-year coronary heart disease risk, and high-density lipoprotein cholesterol and fasting blood glucose were significantly higher at follow-up.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

“…Although bariatric surgery can decrease CIMT, the long-term effects of these weight control approaches on reducing the risk of cardiovascular disease remain a matter of debate (8)(9)(10)(11)(12)(13)(14)(15)(16). There is scant evidence about the impact of weight loss through bariatric surgery or nonsurgical approaches on subclinical atherosclerosis and CVRFs in class 3 obesity.…”

Section: Introductionmentioning

confidence: 99%

Bariatric Surgery‐Induced Changes in Intima‐Media Thickness and Cardiovascular Risk Factors in Class 3 Obesity: A 3‐Year Follow‐Up Study

Domènech-Ximenos

Cuba

Daunis‐i‐Estadella

et al. 2020

Obesity

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Objective The impact of weight loss induced by bariatric surgery (BS) and nonsurgical approaches on cardiovascular risk factors (CVRFs) has not been fully elucidated. We assessed the effects of BS and a nonsurgical approach on carotid intima‐media thickness (CIMT) and CVRFs in participants with class 3 obesity. Methods A total of 87 participants with obesity (59 women; 46 [37‐52] years old; BMI, 43 [40‐47]) and 75 controls were recruited; 21 (25%) participants with obesity underwent BS. BMI, blood pressure, cholesterol, triglycerides, fasting plasma glucose, C‐reactive protein, CIMT, and Framingham Risk Score were measured at baseline and at 3‐year follow‐up. Independent factors for reduction in CIMT were analyzed. The literature on the effects of BS and CIMT was reviewed. Results After BS, BMI decreased from 45.45 to 27.28 (P < 0.001), and mean CIMT decreased from 0.64 mm (0.56‐0.75 mm) to 0.54 mm (0.46‐0.65) mm (P < 0.012), equivalent to 0.005 mm/kg of weight lost. At 3‐year follow‐up, participants who had undergone BS had similar CIMT and CVRFs to the control group. No changes in CVRFs were seen related to the nonsurgical approach. BMI reduction after BS had the strongest independent association with decreased CIMT. Conclusions Weight loss after BS decreases CIMT and CVRFs in middle‐aged participants with class 3 obesity, resulting in CIMT similar to that observed in lean participants.

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Age-Related Effects of Bariatric Surgery on Early Atherosclerosis and Cardiovascular Risk Reduction

Cited by 21 publications

References 26 publications

Improvement of Cardiac Function After Roux-en-Y Gastric Bypass in Morbidly Obese Patients Without Cardiac History Measured by Cardiac MRI

Improvement of Cardiac Function After Roux-en-Y Gastric Bypass in Morbidly Obese Patients Without Cardiac History Measured by Cardiac MRI

Emerging measurements of atherosclerosis: extra-media thickness, epicardial adipose tissue, and periarterial adipose tissue intima media adventitia index in morbidly obese patients undergoing bariatric surgery.

Bariatric Surgery‐Induced Changes in Intima‐Media Thickness and Cardiovascular Risk Factors in Class 3 Obesity: A 3‐Year Follow‐Up Study

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