Age-related elemental change in bones

The effects of strontium ranelate treatment on ovariectomized Sprague-Dawley rat tibia

“…Ca decreased more in cancellous bone than in cortical bone, as well as Sr. It confirmed our previous result that the decreasing tendency of Sr in lumbar was more rapid than that in femur with ages [6]. After strontium ranelate treatment, Ca and Sr content in group C was larger than that in group B.…”

“…However, adequate calcium with vitamin D supplementation is not enough to ensure optimal bone health [5]. Our previous study [6] also showed that there were no age-related change in Ca and P content. Instead, an obvious decline in Sr content was observed, although the total amount of Sr in bone is very low as compared with Ca.…”

Characterization of Ca-phosphate biological materials by scanning transmission X-ray microscopy (STXM) at the Ca L2,3-, P L2,3- and C K-edges

“…Most previous XANES studies of P minerals have focused on the P K-edge at $2150 eV [67][68][69][70][71]. Soft X-ray STXM allows for the measurement of XANES spectra at the P L 2,3 -edges which lie at around 130-150 eV.…”

Evaluating the consequences of diagenesis and fossilization on bioapatite lattice structure and composition

“…However, there has been relatively limited research done to understand the timing and significance of the processes and mechanisms that control compositional changes to bone (e.g, Person et al, 1995;Reynard et al, 1998;Nielsen-Marsh and Hedges, 2000;Trueman and Tuross, 2002;Kohn, 2008;Wang et al, 2008;Koenig et al, 2009;Herwartz et al, 2011).…”

“…XANES spectroscopy provides insight into bond sharing and ion coordination with surrounding elements (Franke and Hormes, 1995;Salbu et al, 2005;Voegelin et al, 2010). But, this method has not been widely used to evaluate bone composition (Eichert et al, 2006;Wang et al, 2008;Rajendran, 2011), despite the potential to refine our understanding of bone chemistry. We expected that XANES spectroscopic analyses would provide information about molecular-level configurations for fossilized bones that had been previously unrecognized by using the other approaches.…”