The effects of strontium ranelate treatment on ovariectomized Sprague-Dawley rat tibia

Zheng, Yi; Wei-fang, Jin; Wang, C.; Yang, Ming; Shen, H. F.; Eisa, M. H.; Mei, Yong

doi:10.1016/j.nimb.2009.03.066

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…These data are however crucial for evaluating the right dose to deliver for positive effects, and matching the implant properties in view of this. Rare studies investigated the accumulation of Sr in bone, often in the case of oral administration of Sr [5,6]. To our knowledge, the only measurement reported in the literature about the in vivo release of Sr from bioceramics is found in a study by Gorustovich et al [7].…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface

Lao¹,

Lacroix²,

Nohra³

et al. 2013

Bioceram Dev Appl

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Studying the local release of strontium traces in vivo is of key interest, but calls for highly sensitive techniques besides providing an excellent (micronic) spatial resolution. In this context nuclear microprobes such as the PIXE (Particle-Induced X-ray Emission) technique, appear as powerful tools of investigation. Here, the in vivo behaviour of a Sr-delivering bioactive glass has been investigated through micro-PIXE analyses in connection with histological studies. New bone formation is observed after 6 weeks of implantation in rabbit femoral condyle. Interestingly, Sr traces are detected over a large area at the site of implantation, demonstrating the efficient release of Sr osteo inductive ions from the glass and their diffusion over several ten microns through the tissues. From its inorganic composition and content in traces of interest such as Zn, neo formed bone seems of higher quality for Sr-delivering particles compared to Sr-free particles, evidencing the positive effect of Sr in vivo.

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Section: Introductionmentioning

confidence: 99%

Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface

Lao¹,

Lacroix²,

Nohra³

et al. 2013

Bioceram Dev Appl

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“…Such treatments have been shown also to increase bone mass in postmenopausal osteoporosis patients (Boivin et al, 1996;Farlay et al, 2005;Marie, 2005;Roux, 2007;Rochefort et al, 2010;Roschger et al, 2010). Many studies have been performed to investigate the spatial repartition in tissues as well as the local environment of this oligoelement (Dahl et al, 2001;Verberckmoes et al, 2004;Korbas et al, 2004;Zhang et al, 2005;Ni et al, 2006;Bradley et al, 2007a,b;Zoeger et al, 2008;Zheng et al, 2009;Bellis et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The status of strontium in biological apatites: an XANES investigation

Bazin

Daudon

Chappard

et al. 2011

J Synchrotron Radiat

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Osteoporosis represents a major public health problem and increases patient morbidity through its association with fragility fractures. Among the different treatments proposed, strontium-based drugs have been shown to increase bone mass in postmenopausal osteoporosis patients and to reduce fracture risk. While the localization of Sr(2+) cations in the bone matrix has been extensively studied, little is known regarding the status of Sr(2+) cations in natural biological apatite. In this investigation the local environment of Sr(2+) cations has been investigated through XANES (X-ray absorption near-edge structure) spectroscopy in a set of pathological and physiological apatites. To assess the localization of Sr(2+) cations in these biological apatites, numerical simulations using the ab initio FEFF9 X-ray spectroscopy program have been performed. The complete set of data show that the XANES part of the absorption spectra may be used as a fingerprint to determine the localization of Sr(2+) cations versus the mineral part of calcifications. More precisely, it appears that a relationship exists between some features present in the XANES part and a Sr(2+)/Ca(2+) substitution process in site (I) of crystal apatite. Regarding the data, further experiments are needed to confirm a possible link between the relationship between the preparation mode of the calcification (cellular activity for physiological calcification and precipitation for the pathological one) and the adsorption mode of Sr(2+) cations (simple adsorption or insertion). Is it possible to draw a line between life and chemistry through the localization of Sr in apatite? The question is open for discussion. A better structural description of these physiological and pathological calcifications will help to develop specific therapies targeting the demineralization process in the case of osteoporosis.

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Investigation of strontium accumulation on ovariectomized Sprague–Dawley rat tibia by micro-PIXE

Wei-fang

et al. 2014

Nuclear Instruments and Methods in Physics Research Section B:

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The effects of strontium ranelate treatment on ovariectomized Sprague-Dawley rat tibia

Cited by 3 publications

References 26 publications

Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface

Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface

The status of strontium in biological apatites: an XANES investigation

Investigation of strontium accumulation on ovariectomized Sprague–Dawley rat tibia by micro-PIXE

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