Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study

Donald, L.; Rosenfeld, Margaret; Mancl, Lloyd; Chung, Whasun O.; Presland, Richard B.; Sarvas, Elise; Rothen, Marilynn; Alkhateeb, Alaa A.; McNamara, Sharon; Genatossio, Alan; Virella‐Lowell, Isabel; Milla, Carlos; Scott, Joanna

doi:10.1016/j.jcf.2018.06.009

Cited by 12 publications

(27 citation statements)

References 23 publications

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“…This is the same questionnaire that was used for a previously published study. 18 Caregivers completed the questionnaire with input solicited from the child as needed. Children received a dental screening.…”

Section: Study Proceduresmentioning

confidence: 99%

Oral health behaviours and dental caries in low‐income children with special healthcare needs: A prospective observational study

Lee

Scott

Donald

2020

Int J Paed Dentistry

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Dental caries is a significant public health problem for children with special healthcare needs (CSHCN). 1 A recent study from North Carolina showed that CSHCN have a higher caries risk and caries burden than healthy children. 2 Another study reported that among low-income Head Start enrolees, children with developmental delays had significantly higher caries prevalence. 3 In terms of aetiology, dental caries is a multifactorial disease linked to three main oral health behaviours: high carbohydrate diet, inadequate fluoride exposure and poor access to dental care. Dental caries is associated with added sugar intake. Children with autism spectrum disorders consume significantly more sugar-sweetened beverages servings per day (eg juice, punch, soda) than healthy children without autism (2.6 vs 1.7, respectively; P = .03) and snack foods like candy, chips, cookies and crackers (4.0 vs 3.0; P = .01), and significantly fewer daily servings of fruits and vegetables (3.1 vs 4.4; P < .01). 4 Additional diet-related risk factors for CSHCN include delayed feeding skills and feeding problems, which can lead to increased intake of soft foods, nutritional supplements with

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Section: Study Proceduresmentioning

confidence: 99%

Oral health behaviours and dental caries in low‐income children with special healthcare needs: A prospective observational study

Lee

Scott

Donald

2020

Int J Paed Dentistry

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“…Oral health is an important component of overall health in the general population, but there are few studies in CF. A prospective, observational study in 85 people with CF, ages 6 to 20 years, found that when compared with control, children with CF aged 6 to 9 years had a lower rate of caries than controls, but there were no differences in the group aged 10 to 20 years . A number of risk factors were found to explain the loss of protection against carries as a patient with CF age.…”

Section: Multisystem Effects Of Cystic Fibrosismentioning

confidence: 99%

“…A prospective, observational study in 85 people with CF, ages 6 to 20 years, found that when compared with control, children with CF aged 6 to 9 years had a lower rate of caries than controls, but there were no differences in the group aged 10 to 20 years. 41 A number of risk factors were found to explain the loss of protection against carries as a patient with CF age. Similar findings were discussed in a systematic review of dental health in CF, with CF patients having equal or lesser caries risk and more enamel defects in permanent dentition than non-CF controls.…”

Section: Oral Healthmentioning

confidence: 99%

“…IQR] 1301 kcal/d vs 686; P < .0001) and proportion of energy intake (median [IQR] 44%[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] vs 31%[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]; P < .0001). Thus, while children with CF met their energy requirements and ate ample fat, this was largely due to ingestion of EDNP foods.…”

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confidence: 99%

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Cystic fibrosis year in review 2018, part 2

Savant

McColley

2019

Pediatric Pulmonology

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“…1 The association between CF and caries risk has been established in young children, but relatively less information exists on its association with periodontal inflammation. [3][4][5][6] Although children with CF are reported to have a higher prevalence of calculus due to deregulated calcium and phosphate levels in their saliva, 3 it is not conclusive if other salivary factors are associated with and/or reflect CF. There is an increasing evidence that expression of triggering receptor expressed on myeloid cells 1 (TREM-1), along with its putative ligand peptidoglycan recognition protein 1 (PGLYRP1), is significantly increased in saliva in the presence of chronic inflammatory diseases including periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis

Yücel

Silbereisen

Emingil

et al. 2020

Journal of Periodontology

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Background: Cystic fibrosis (CF) is a life-threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as a reservoir of bacterial colonization and potentially reflect systemic inflammation. This study investigated whether salivary triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1), interleukin (IL)-1 , and calprotectin are associated with CF or reflect concomitant gingival inflammation. Methods: Ten CF (aged 3 to 12 years) and 10 systemically healthy (SH) age-and sexmatched children (C) were enrolled in the study. Individuals with CF underwent routine laboratory determinations. Probing depth, gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were recorded on fully erupted teeth and saliva samples collected. Salivary TREM-1, PGLYRP1, IL-1 , and calprotectin were analyzed by enzyme-linked immunosorbent assay. Results: Children with CF had significantly higher BOP scores (P = 0.001) and calprotectin levels (P = 0.017) compared with the C group. TREM-1, PGLYRP1, and IL-1 could not distinguish between CF and SH but showed positive correlation with GI, PI, and BOP in both groups. Calprotectin levels positively correlated with procalcitonin (P = 0.014), thrombocyte counts (P = 0.001), mean platelet volume (P = 0.030), and with PGLYRP1 (P = 0.019) and IL-1 (P = 0.013) in CF children. Receiver operating characteristic curve analysis for calprotectin (CFvsC) showed an area under the curve of 0.79 (95% CI 0.58 to 0.99, P = 0.034). Conclusions: CF children presented with higher gingival inflammation scores and salivary calprotectin levels, that correlated with systemic inflammatory markers. Salivary calprotectin levels were not associated with periodontal parameters. Hence, preliminary data demonstrate that salivary calprotectin might have a chairside diagnostic potential for CF in children.

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Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study

Abstract: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.

Cited by 12 publications

References 23 publications

Oral health behaviours and dental caries in low‐income children with special healthcare needs: A prospective observational study

Oral health behaviours and dental caries in low‐income children with special healthcare needs: A prospective observational study

Cystic fibrosis year in review 2018, part 2

Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis

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