2005
DOI: 10.1016/j.neuroscience.2004.12.043
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Age-related loss of the GABA synthetic enzyme glutamic acid decarboxylase in rat primary auditory cortex

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Cited by 154 publications
(134 citation statements)
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“…In contrast, a substantial decrease with aging in the levels of other markers in the auditory cortex of rats was reported in the case of GABA (Ling et al 2005), NADPH-diaphorase (Ouda et al 2003) and acetylcholine (Stemmelin et al, 2000). In our study we evaluate age-related…”
Section: Introductionmentioning
confidence: 86%
See 1 more Smart Citation
“…In contrast, a substantial decrease with aging in the levels of other markers in the auditory cortex of rats was reported in the case of GABA (Ling et al 2005), NADPH-diaphorase (Ouda et al 2003) and acetylcholine (Stemmelin et al, 2000). In our study we evaluate age-related…”
Section: Introductionmentioning
confidence: 86%
“…In studies of aging, there are not available specific "indifferent A C C E P T E D M A N U S C R I P T 8 reference structures" in the brain for normalization, hence we calculated the normalized value of the optical density in each section as the ratio between the average optical density of the analyzed PV-ir neurons in the section and the average optical density of a corresponding number of immunonegative cells in the same section (compare Ling et al, 2005). In most cases the immunopositivity of the neurons was explicit; in a few disputable cases, a selected neuron was omitted from the analysis as "non-PV-ir" unless the measured optical density of its soma was higher than double of the average optical density of immunonegative cells in the same section.…”
Section: Stereological Quantificationmentioning
confidence: 99%
“…Decreases in the levels of GAD65 and GAD67 mRNAs and in the optical density of GAD67-immunoreactive cells were observed in the auditory cortex of old Fischer 344/Brown Norway rat (Ling et al, 2005).…”
Section: Introductionmentioning
confidence: 91%
“…In studies of aging, there are not specific "indifferent reference structures" available in the brain for normalization, hence we calculated the normalized value of the optical density in each section as the ratio between the average optical density of the analyzed GAD-ir neurons in the section and the average optical density of a corresponding number of immunonegative cells in the same section (compare Ling et al, 2005). In most cases the immunopositivity of the neurons was explicit; in a few disputable cases, a selected neuron was omitted from the analysis as "non-GAD-ir" unless the measured optical density of its soma was higher than double the average optical density of immunonegative cells in the same section.…”
Section: Immunohistochemistry -Stereological Quantificationmentioning
confidence: 99%
“…First, an age-dependent decrease of intracortical inhibition may account for the enhanced long-range connectivity in older age. Animal studies on gamma aminobutyric acid (GABA), which is the most important inhibitory neurotransmitter of the brain, have consistently shown an age-related decrease of GABA effectiveness in the auditory pathways (Caspary et al, 1995(Caspary et al, , 1999Ling et al, 2005;Walton et al, 1998Walton et al, , 2002. Similar findings exist for the visual system which also show a decrease of GABA functioning (Liang et al, 2010;Yang et al, 2008).…”
mentioning
confidence: 86%