Age-related macular degeneration

Guymer, Robyn H.; Campbell, T. G.

doi:10.1016/s0140-6736(22)02609-5

Cited by 131 publications

(53 citation statements)

References 145 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Type 1 MNV grows from the choriocapillaris into the sub‐RPE space, while type 2 MNV arises from the choroid into the subretinal space. Type 3 MNV is a downgrowth of vessels from the retinal vascular plexus towards the outer retina 25–27 . This classification of MNV subtypes improves the assessment of disease impact and treatment potential.…”

Section: Aetiology Classification Pathophysiology and Signal Pathway ...mentioning

confidence: 99%

See 1 more Smart Citation

CRISPR‐based gene therapy for wet age‐related macular degeneration in mouse model

Xie,

Chen,

et al. 2024

Clinical and Translational Dis

View full text Add to dashboard Cite

Wet age‐related macular degeneration (AMD) is a common cause of vision loss in the elderly. It is characterised by choroidal neovascularisation (CNV), caused by overexpression of vascular endothelial growth factor (VEGF), resulting in abnormal vessel proliferation. Current clinical management predominantly relies on anti‐VEGF agents, which require frequent and costly injections. Clustered regularly interspaced short palindromic repeats (CRISPR) technology has emerged as a promising strategy for permanently suppressing angiogenesis by targeting the VEGF‐related pathway. Increased research suggests that disrupting this pathway holds potential for preventing CNV progression. This review provides an overview of the aetiology, classification and pathophysiology of wet AMD, followed by a concise summary of current gene editing research using the CRISPR/Cas system via viral vector delivery strategies to target ocular pro‐angiogenic factors, including Hif‐1α, VEGF and VEGFR. The importance of timely targeting of VEGFA is emphasised and the challenges associated with gene editing therapies are also highlighted.

show abstract

Section: Aetiology Classification Pathophysiology and Signal Pathway ...mentioning

confidence: 99%

“…Type 3 MNV is a downgrowth of vessels from the retinal vascular plexus towards the outer retina. [25][26][27] This classification of MNV subtypes improves the assessment of disease impact and treatment potential.…”

Section: Aetiology Classification Pathophysiology and Signal Pathway ...mentioning

confidence: 99%

CRISPR‐based gene therapy for wet age‐related macular degeneration in mouse model

Xie,

Chen,

et al. 2024

Clinical and Translational Dis

View full text Add to dashboard Cite

show abstract

“…In 1993, K. Bailey Freund, MD, and colleagues [36] studied a series of patients with neovascular age-related macular degeneration (AMD) to determine eligibility for laser photocoagulation treatment. Today, however, laser photocoagulation for AMD has largely been replaced by new anti-VEGF agents [37] . A randomized controlled trial by Donald S Fong et al [38] compared two laser photocoagulation techniques for treating diabetic macular edema (DME): the modi ed Early Treatment Diabetic Retinopathy Study (ETDRS) direct/grid photocoagulation technique and a potentially milder mild macular grid (MMG) laser.…”

Section: Identi Cation Of Research Trends and Future Of Evidence Synt...mentioning

confidence: 99%

Trends in Worldwide research on laser in ophthalmology over the period 1990-2022: A bibliometric study of hotspots, nodes, bursts, and trends

Jiang,

Cai,

Zhang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Laser therapy has been proven as an effective technique for managing ophthalmological disorders. To guide future research, we conducted a bibliometric analysis of laser applications in eye diseases from 1990 to 2022, aiming to identify key themes and trends. Methods we retrieved 3027 publications from the Web of Science Core Collection (WoSCC). Bibliometrix was used for science mapping of the literature, while VOSviewer and CiteSpace were applied to visualize co-authorship, co-citation, co-occurrence, and bibliographic coupling networks. Results From a co-citation reference network, we identified 52 distinct clusters. Our analysis uncovered three main research trends. The first trend revolves around the potential evolution of corneal laser surgery techniques, shifting from the treatment of refractive errors to broader applications in biomedical optics. The second trend illustrates the advancement of laser applications in treating a range of disorders, from retinal and ocular surface diseases to glaucoma. The third trend focuses on the innovative uses of established technologies. Conclusions This study offers significant insights into the evolution of laser applications in ophthalmology over the past 30 years, which will undoubtedly assist scientists in directing further research in this promising field.

show abstract

“…For wet AMD, the fragile neovasculature from the choroid breaks into the Bruch membrane and forms a choroidal neovascular membrane. The process of neovascularization will destroy the architecture of the overlying RPE and the outer retina, thereby causing serious visual impairments [ 3 ]. Although wet AMD only accounts for 20% of patients with AMD, 90% of these patients have severe visual impairment [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives

Zhang,

Wang,

et al. 2024

Gels

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is an ocular disease that leads to progressive photoreceptor death and visual impairment. Currently, the most common therapeutic strategy is to deliver anti-vascular endothelial growth factor (anti-VEGF) agents into the eyes of patients with wet AMD. However, this treatment method requires repeated injections, which potentially results in surgical complications and unwanted side effects for patients. An effective therapeutic approach for dry AMD also remains elusive. Therefore, there is a surge of enthusiasm for the developing the biodegradable drug delivery systems with sustained release capability and develop a promising therapeutic strategy. Notably, the strides made in hydrogels which possess intricate three-dimensional polymer networks have profoundly facilitated the treatments of AMD. Researchers have established diverse hydrogel-based delivery systems with marvelous biocompatibility and efficacy. Advantageously, these hydrogel-based transplantation therapies provide promising opportunities for vision restoration. Herein, we provide an overview of the properties and potential of hydrogels for ocular delivery. We introduce recent advances in the utilization of hydrogels for the delivery of anti-VEGF and in cell implantation. Further refinements of these findings would lay the basis for developing more rational and curative therapies for AMD.

show abstract

Age-related macular degeneration

Cited by 131 publications

References 145 publications

CRISPR‐based gene therapy for wet age‐related macular degeneration in mouse model

CRISPR‐based gene therapy for wet age‐related macular degeneration in mouse model

Trends in Worldwide research on laser in ophthalmology over the period 1990-2022: A bibliometric study of hotspots, nodes, bursts, and trends

Hydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives

Contact Info

Product

Resources

About