Age related normogram for antral follicle count in general population and comparison with previous studies

Bozdağ, Gürkan; Çalış, Pınar; Zengin, Dila; Karahan, Sevilay

doi:10.1016/j.ejogrb.2016.09.013

Cited by 21 publications

(16 citation statements)

References 34 publications

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“…However, studies indicate that at any given age, there is a considerable variation in serum AMH levels ( 14 , 17 , 18 ). Thus, similar to what has been observed for antral follicle count (AFC), large interindividual variation exists for AMH levels ( 19 , 20 ). Ethnicity may contribute to this variation and should be taken into account when interpreting AMH values.…”

Section: Serum Amh Levels In the General Populationsupporting

confidence: 66%

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Moolhuijsen

Visser

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

330

235

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Context Anti-Müllerian hormone is produced by granulosa cells of small growing follicles in the ovary. Serum AMH levels strongly correlate with the number of growing follicles, and therefore it has received increasing attention as a marker for ovarian reserve. This review summarizes recent findings and limitations in the application of serum AMH in ovarian reserve assessment. Evidence acquisition A PubMed search was conducted to find recent literature on the measurements and use of serum AMH as a marker for ovarian reserve. Evidence synthesis Serum AMH levels are measured to assess the ‘functional ovarian reserve’, a term that is preferred over ‘ovarian reserve’, since AMH levels reflect the pool of growing follicles which potentially can ovulate. Serum AMH levels are used in individualized FSH dosing protocols and may predict the risk of poor response or OHSS, but has limited value in predicting ongoing pregnancy. Serum AMH levels are studied to predict natural or disease-related age of menopause. Studies show that the age-dependent decline rates of AMH vary among women. The generalized implementation of serum AMH measurement has also lead to an increase in diagnostic assays, including automated assays. However, direct comparison of results remains problematic. Conclusion Serum AMH remains the preferred ovarian reserve marker. However, the lack of an international standard for AMH limits comparison between AMH assays. Furthermore, still little is known about endogenous and exogenous factors that influence serum AMH levels, which limits proper interpretation of AMH values in a clinical setting.

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Section: Serum Amh Levels In the General Populationsupporting

confidence: 66%

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Moolhuijsen

Visser

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

330

235

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“…A prospective cross-sectional study included 381 women aged 20-50 years with regular menstrual cycle and count number of AFC based on transvaginal ultrasound in the early follicular phase. The result showed that there were no significant differences in AFC among different age groups under 35 years, whereas a significant decrease after 35 years [23]. Bishop et al analyzed the relationship between live birth and ovarian reserve in 9489 cycles among 8214 patients aged 21-44 years.…”

Section: Discussionmentioning

confidence: 99%

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

et al. 2020

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Purpose: Problems with fallopian tubes are one of the main reasons for women to undergo in vitro fertilizationembryo transfer (IVF-ET). A large proportion of women with ectopic pregnancy, fallopian tube obstruction and hydrosalpinx have had one or both fallopian tubes removed by salpingectomy. With increasing age, ovarian reserve deteriorates, the numbers of retrieved oocytes, available embryos and high-quality embryos are reduced, and the live birth rate for women treated with IVF treatment is affected. Thus, it is important to understand how salpingectomy affects live birth rates for IVF patients of different ages. This study analyzed how patients' age and salpingectomy influenced ovarian reserve, ovarian response and pregnancy outcomes for infertile women undergoing IVF-ET. Methods: A total of 1922 patients that underwent IVF-ET treatment from January 1, 2012, to December 31, 2018, were included in this retrospective study. The patients were divided into two groups according to whether or not they had a previous history of salpingectomy. The salpingectomy (group A, 534 patients) and control groups (group B, 1388 patients) were then further divided into two subgroups according to patient age (age<35 years, and age 35-39 years). Ovarian reserve, ovarian response, and IVF outcomes were investigated for each subgroup. Logistic regression model was used to estimate the relationship between clinical pregnancy and live births and patients' baseline characteristics. Results: In the salpingectomy group, antral follicle counts (AFC) were significantly lower for the subgroup aged 35 to 39 years compared with the control group. But this difference did not appear in women younger than 35 years. In addition, there were no significant differences in levels of basal follicle stimulation hormone (FSH), basal luteinizing hormone (LH), basal estradiol (E 2), total gonadotropins (Gn) dose, duration of Gn, numbers of retrieved oocytes, fertilization rates, numbers of available embryos, live birth rates, clinical pregnancy rates, miscarriage rates, ectopic pregnancy rates, or multiple pregnancy rates between the salpingectomy group and the control group (P > 0.05). Age is a risk factor for the clinical pregnancy and live birth. Conclusion: Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35-39 years. The increased female age was negative related with clinical pregnancy and live birth.

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“…Furthermore, we found that, on average, POSEIDON patients had a higher BMI and, more often, a female infertility factor associated with this condition (versus non-POSEIDON). The relationship between female age, ovarian markers and ART reproductive success is well-established ( 31 – 33 ), and BMI has been shown to influence the number of oocytes retrieved and embryos obtained, as well as pregnancy outcomes ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Low Prognosis by the POSEIDON Criteria in Women Undergoing Assisted Reproductive Technology: A Multicenter and Multinational Prevalence Study of Over 13,000 Patients

Esteves¹,

Yaralı́

Vuong

et al. 2021

Front. Endocrinol.

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ObjectiveTo estimate the prevalence of low-prognosis patients according to the POSEIDON criteria using real-world data.DesignMulticenter population-based cohort study.SettingsFertility clinics in Brazil, Turkey, and Vietnam.PatientsInfertile women undergoing assisted reproductive technology using standard ovarian stimulation with exogenous gonadotropins.InterventionsNone.Main outcome measuresPer-period prevalence rates of POSEIDON patients (overall, stratified by POSEIDON groups and by study center) and the effect of covariates on the probability that a patient be classified as “POSEIDON”.ResultsA total of 13,146 patients were included. POSEIDON patients represented 43.0% (95% confidence interval [CI] 42.0–43.7) of the studied population, and the prevalence rates varied across study centers (range: 38.6–55.7%). The overall prevalence rates by POSEIDON groups were 44.2% (group 1; 95% CI 42.6–45.9), 36.1% (group 2; 95% CI 34.6–37.7), 5.2% (group 3; 95% CI 4.5–6.0), and 14.4% (group 4; 95% CI: 13.3–15.6). In general, POSEIDON patients were older, had a higher body mass index (BMI), lower ovarian reserve markers, and a higher frequency of female factor as the primary treatment indication than non-POSEIDON patients. The former required larger doses of gonadotropin for ovarian stimulation, despite achieving a 2.5 times lower number of retrieved oocytes than non-POSEIDON patients. Logistic regression analyses revealed that female age, BMI, ovarian reserve, and a female infertility factor were relevant predictors of the POSEIDON condition.ConclusionsThe estimated prevalence of POSEIDON patients in the general population undergoing ART is significant. These patients differ in clinical characteristics compared with non-POSEIDON patients. The POSEIDON condition is associated with female age, ovarian reserve, BMI, and female infertility. Efforts in terms of diagnosis, counseling, and treatment are needed to reduce the prevalence of low-prognosis patients.

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Age related normogram for antral follicle count in general population and comparison with previous studies

Cited by 21 publications

References 34 publications

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

Low Prognosis by the POSEIDON Criteria in Women Undergoing Assisted Reproductive Technology: A Multicenter and Multinational Prevalence Study of Over 13,000 Patients

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