Age-related reference curves of volumetric bone density, structure, and biomechanical parameters adjusted for weight and height in a population of healthy women: an HR-pQCT study

Alvarenga, Jackeline Couto; Fuller, Henrique; Pasoto, Sandra Gofinet; Pereira, Rosa Maria Rodrigues

doi:10.1007/s00198-016-3876-0

Cited by 46 publications

(50 citation statements)

References 43 publications

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“…First, our results showed that Ct.Th and Ct.Po, as depicted by BDAT, exhibited significant age‐related dependence for women: Concurrent with the increased porosity, the thickness at the radius was reduced with aging. These results are consistent with data obtained previously with HRpQCT . Second, Ct.Th and Ct.Po were associated with fracture.…”

Section: Discussionsupporting

confidence: 93%

“…These results are consistent with data obtained previously with HRpQCT. (10,56,(59)(60)(61)(62)(63) Second, Ct.Th and Ct.Po were associated with fracture. There are no equivalent studies comparable to ours; however, many cross-sectional and retrospective studies have evaluated the association of HRpQCTderived cortical structural variables, Ct.Th and Ct.Po, measured at the ultradistal radius, with odds of prior fracture in women.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasound-Based Estimates of Cortical Bone Thickness and Porosity Are Associated With Nontraumatic Fractures in Postmenopausal Women: A Pilot Study

Minonzio

Bochud

Vallet

et al. 2019

Journal of Bone and Mineral Research

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Recent ultrasound (US) axial transmission techniques exploit the multimode waveguide response of long bones to yield estimates of cortical bone structure characteristics. This pilot cross‐sectional study aimed to evaluate the performance at the one‐third distal radius of a bidirectional axial transmission technique (BDAT) to discriminate between fractured and nonfractured postmenopausal women. Cortical thickness (Ct.Th) and porosity (Ct.Po) estimates were obtained for 201 postmenopausal women: 109 were nonfractured (62.6 ± 7.8 years), 92 with one or more nontraumatic fractures (68.8 ± 9.2 years), 17 with hip fractures (66.1 ± 10.3 years), 32 with vertebral fractures (72.4 ± 7.9 years), and 17 with wrist fractures (67.8 ± 9.6 years). The areal bone mineral density (aBMD) was obtained using DXA at the femur and spine. Femoral aBMD correlated weakly, but significantly with Ct.Th (R = 0.23, p < 0.001) and Ct.Po (R = ‐0.15, p < 0.05). Femoral aBMD and both US parameters were significantly different between the subgroup of all nontraumatic fractures combined and the control group (p < 0.05). The main findings were that (1) Ct.Po was discriminant for all nontraumatic fractures combined (OR = 1.39; area under the receiver operating characteristic curve [AUC] equal to 0.71), for vertebral (OR = 1.96; AUC = 0.84) and wrist fractures (OR = 1.80; AUC = 0.71), whereas Ct.Th was discriminant for hip fractures only (OR = 2.01; AUC = 0.72); there was a significant association (2) between increased Ct.Po and vertebral and wrist fractures when these fractures were not associated with any measured aBMD variables; (3) between increased Ct.Po and all nontraumatic fractures combined independently of aBMD neck; and (4) between decreased Ct.Th and hip fractures independently of aBMD femur. BDAT variables showed comparable performance to that of aBMD neck with all types of fractures (OR = 1.48; AUC = 0.72) and that of aBMD femur with hip fractures (OR = 2.21; AUC = 0.70). If these results are confirmed in prospective studies, cortical BDAT measurements may be considered useful for assessing fracture risk in postmenopausal women. © 2019 American Society for Bone and Mineral Research.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ultrasound-Based Estimates of Cortical Bone Thickness and Porosity Are Associated With Nontraumatic Fractures in Postmenopausal Women: A Pilot Study

Minonzio

Bochud

Vallet

et al. 2019

Journal of Bone and Mineral Research

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“…(For comparison, postmenopausal women had a 4% to 8% increase in cortical porosity of the distal tibia over 2 years in a clinical trial (9) and 300% higher cortical porosity when compared with premenopausal women in a cross-sectional study. (10) ) However, it should be kept in mind that this technology is not examining the vertebrae or femoral neck, where comparatively greater (5% to 10%) losses appear to occur as assessed by DXA; the distal tibia is not specifically examined by DXA.…”

mentioning

confidence: 99%

Irreversible Deterioration of Cortical and Trabecular Microstructure Associated With Breastfeeding

Bjørnerem

Ghasem‐Zadeh

Wang

et al. 2016

Journal of Bone and Mineral Research

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Estrogen deficiency associated with menopause is accompanied by an increase in the rate of bone remodeling and the appearance of a remodeling imbalance; each of the greater number of remodeling transactions deposits less bone than was resorbed, resulting in microstructural deterioration. The newly deposited bone is also less completely mineralized than the older bone resorbed. We examined whether breastfeeding, an estrogen-deficient state, compromises bone microstructure and matrix mineral density. Distal tibial and distal radial microarchitecture were quantified using high-resolution peripheral quantitative computed tomography in 58 women before, during, and after breastfeeding and in 48 controls during follow-up of 1 to 5 years. Five months of exclusive breastfeeding increased cortical porosity by 0.6% (95% confidence interval [CI] 0.3-0.9), reduced matrix mineralization density by 0.26% (95% CI 0.12-0.41) (both p < 0.01), reduced trabecular number by 0.22 per mm (95% CI 0.15-0.28), and increased trabecular separation by 0.07 mm (95% CI 0.05-0.08) (all p < 0.001). Relative to prebreastfeeding, at a median of 2.6 years (range 1 to 4.8) after cessation of breastfeeding, cortical porosity remained 0.58 SD (95% CI 0.48-0.68) higher, matrix mineralization density remained 1.28 SD (95% CI 1.07-1.49) lower, and trabeculae were 1.33 SD (95% CI 1.15-1.50) fewer and 1.06 SD (95% CI 0.91-1.22) more greatly separated (all p < 0.001). All deficits were greater than in controls. The results were similar at distal radius. Bone microstructure may be irreversibly deteriorated after cessation of breastfeeding at appendicular sites. Studies are needed to establish whether this deterioration compromises bone strength and increases fracture risk later in life.

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“…Em seguida, foram analisadas a partir do método semiquantitativo de Genant (Genant et al, 1993). (Fuller et al, 2015;Alvarenga et al, 2017). Para análise dos parâmetros de densidade e estrutura, foi utilizado o software "Standard analysis".…”

Section: Avaliação Laboratorial Do Perfil Bioquímico Do Metabolismo óunclassified

“…Um software de segmentação automática chamado "Advanced cortical analysis" foi utilizado para determinar a porosidade cortical (Ct.Po) (Alvarenga et al, 2017).…”

Section: Avaliação Laboratorial Do Perfil Bioquímico Do Metabolismo óunclassified

Associação de fraturas vertebrais moderadas e graves com menor densidade volumétrica trabecular na tíbia em mulheres idosas e menor densidade mineral óssea areal em fêmur em homens idosos da comunidade: São Paulo Ageing & Health study (SPAH)

Torres¹,

Pereira²

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Age-related reference curves of volumetric bone density, structure, and biomechanical parameters adjusted for weight and height in a population of healthy women: an HR-pQCT study

Cited by 46 publications

References 43 publications

Ultrasound-Based Estimates of Cortical Bone Thickness and Porosity Are Associated With Nontraumatic Fractures in Postmenopausal Women: A Pilot Study

Ultrasound-Based Estimates of Cortical Bone Thickness and Porosity Are Associated With Nontraumatic Fractures in Postmenopausal Women: A Pilot Study

Irreversible Deterioration of Cortical and Trabecular Microstructure Associated With Breastfeeding

Associação de fraturas vertebrais moderadas e graves com menor densidade volumétrica trabecular na tíbia em mulheres idosas e menor densidade mineral óssea areal em fêmur em homens idosos da comunidade: São Paulo Ageing & Health study (SPAH)

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