Age, sex and reproductive status alter the severity of anorexia in zinc deficient rats

Kawamoto, Jerrolynn C.; Castonguay, Thomas W.; Keen, Carl L.; Stern, Judith S.; Hurley, Lucille S.

doi:10.1016/0031-9384(86)90415-4

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Anorexia, followed by impairment of the senses of taste and smell, is a characteristic symptom of zinc deficiency (Aamodt et al, 1983;Henkin and Aamodt, 1983;Kawamoto et al, 1986). Studies by Hambidge et al (1972) implicate dietary zinc deficiency in Colorado.…”

Section: Mineral and Vitamin Deficienciesmentioning

confidence: 96%

Interaction of anorexia and cultural beliefs in infant malnutrition in Mali

Dettwyler

1989

American J Hum Biol

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Anorexia, the lack of a normal appetite or refusal to eat, has been reported among infants and young children worldwide. Many factors can contribute to anorexia, including a monotonous diet, chronic malnutrition, zinc deficiency, disease, anxiety, intestinal parasites, and sores in the mouth. At the same time, ethnographic research reveals wide variation in how, and to what extent, caretakers control food consumption (both quality and quantity) in infants generally, and how they deal with anorexia specifically. In some cultures, children are given considerable autonomy in deciding what and how much food to eat, even when anorectic. In other groups, Children's diets are closely monitored by adult caretakers and anorectic children are urged, or even forced, to eat. Theoretically, the potential for wildespread malnutrition and accompanying growth failure, even in the presence of adequate dietary resources, will be highest in populations which exhibit an interaction of (1) multiple conditions leading to anorexia and (2) cultural beliefs which allow children autonomy in food consumption decisions. Research in Mali provides examples of the potential consequences of the combination for child growth.

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Section: Mineral and Vitamin Deficienciesmentioning

confidence: 96%

Interaction of anorexia and cultural beliefs in infant malnutrition in Mali

Dettwyler

1989

American J Hum Biol

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“…Moreover, cyclic variation in body weight of zinc-deficient rats has been also observed [27]. Kawamoto et al [28] reported that anorexia is the reason of reduced weight in zinc-deficient rats. McNall et al [29] also reported similar findings.…”

Section: Discussionmentioning

confidence: 91%

Tracing of Zinc Nanocrystals in the Anterior Pituitary of Zinc-Deficient Wistar Rats

Kuldeep

Nair

Bedwal

2016

Biol Trace Elem Res

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The aim of this study was to trace zinc nanocrystals in the anterior pituitary of zinc-deficient Wistar rats by using autometallographic technique. Male Wistar rats (30-40 days of age, pre-pubertal period) of 40-50 g body weight were divided into the following: the ZC (zinc control) group-fed with 100 ppm zinc in diet, the ZD (zinc-deficient) group-fed with zinc-deficient (1.00 ppm) diet and the PF (pair-fed) group-received 100 ppm zinc in diet. The experiments were set for 2 and 4 weeks. Pituitary was removed and processed for the autometallographic technique. The control and pair-fed groups retained their normal morphological features. However, male Wistar rats fed on zinc-deficient diet for 2 and 4 weeks displayed a wide range of symptoms such as significant (P < 0.05) decrease in diet consumption, body weight and pituitary weight and decrease in gradation of intensity of zinc nanocrystals in the nuclei. The present findings suggest that the dietary zinc deficiency causes decreased intensity of zinc nanocrystals localization and their distribution in the pituitary thereby contributing to the dysfunction of the pituitary of the male Wistar rats. The severity of zinc deficiency symptoms progressed after the second week of the experiment. Decreased intensity of zinc nanocrystals attenuates the pituitary function which would exert its affect on other endocrine organs impairing their functions indicating that the metabolic regulation of pituitary is mediated to a certain extent by zinc and/or hypothalamus-hypophysial system which also reflects its essentiality during the period of growth.

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“…There was no deficit of zinc in any of the groups studied. Furthermore, the obese rats ate huge amounts of food (Bray & York 1979) and anorexia is a characteristic development of zinc deficiency (Kawamoto et al 1986). …”

Section: Discussionmentioning

confidence: 99%

Management of dietary essential metals (iron, copper, zinc, chromium and manganese) by Wistar and Zucker obese rats fed a self-selected high-energy diet

et al. 1994

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The balances and content of essential elements (iron, copper, zinc, chromium and manganese) in the body of Wistar, Zucker lean and Zucker obese rats fed a reference or cafeteria diet from day 30 to 60 after birth have been studied. Intestinal iron absorption compensated for low iron content of the cafeteria diet and the extra needs of growth and fat deposition. It can be assumed that the altered energy regulation processes that afflict the genetically obese rat are not directly related to altered iron metabolism. Obese Zucker rats had lower copper tissue concentrations than lean rats, but when fed a cafeteria diet the differences between Zucker rats strains disappear. This cannot be traced to large differences in diet copper concentration. A low diet availability of zinc--such as that of cafeteria-fed fa/fa rats--is easily compensated for by increasing absorption. So, as a consequence, we can conclude that genetic obesity did not impair zinc absorption. There was no deficit of zinc in any of the groups studied; the rats have enough capacity to extract zinc within a wide range of dietary concentrations. The absorption of dietary chromium was inversely proportional to its concentration. The ability to extract chromium from the diet and the very low urinary losses are a consequence of its scarcity in most dietary items. Despite wide variations in the manganese of the diets, the absorption rates were practically unchanged except for obese rats fed the cafeteria diet. It seems that this low absorptive capacity is enough to supply the rat with the manganese it needs, since a sizeable--but subjected to 8-fold-span variations--proportion is lost in the urine. This alone points towards a considerable excess of manganese in both diets studied. Obesity does not have a significant effect on the abilities to absorb and retain minerals, since these processes were more related to dietary availability. Management of essential metals by obese rats depends whether this condition is genetic or induced by diet. Most of the differences observed can be related to differences in diet concentration, to the excess fat content or different metabolic attitude to use substrates of obese animals. The data presented show that the cafeteria diet used adequately serves the mineral needs of the rat, since the rat adapts its absorbing and retaining strategies to match the dietary availability of these minerals.

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Age, sex and reproductive status alter the severity of anorexia in zinc deficient rats

Cited by 9 publications

References 18 publications

Interaction of anorexia and cultural beliefs in infant malnutrition in Mali

Interaction of anorexia and cultural beliefs in infant malnutrition in Mali

Tracing of Zinc Nanocrystals in the Anterior Pituitary of Zinc-Deficient Wistar Rats

Management of dietary essential metals (iron, copper, zinc, chromium and manganese) by Wistar and Zucker obese rats fed a self-selected high-energy diet

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