2022
DOI: 10.1093/evolut/qpac027
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Age-specific effects of deletions: implications for aging theories

Abstract: The evolution of aging requires mutations with late-life deleterious effects. Classic theories assume these mutations either have neutral (mutation accumulation) or beneficial (antagonistic pleiotropy) effects early in life, but it is also possible that they start out as mildly harmful and gradually become more deleterious with age. Despite a wealth of studies on the genetics of aging, we still have a poor understanding of how common mutations with age-specific effects are and what aging theory they support. T… Show more

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Cited by 2 publications
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