Age-specific prevalence, transmission and phylogeny of TT virus in the Czech Republic

Saláková, Martina; Němeček, Vratislav; König, J; Tachezy, Ruth

doi:10.1186/1471-2334-4-56

Cited by 32 publications

(35 citation statements)

References 40 publications

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“…This observation has been supported by the detection of TTV in saliva (Naganuma et al 2008), breast milk (Iso et al 2001), semen (Inami et al 2000), faeces (Hamza et al 2011) and water (Diniz-Mendes et al 2008). The observation that the TTV prevalence increased with age in this group of blood donors was consistent with the results of other studies (Saback et al 1999, Salakova et al 2004). …”

supporting

confidence: 85%

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

Massaú

Martins

Nachtigal

et al. 2012

Mem. Inst. Oswaldo Cruz

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supporting

confidence: 85%

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

Massaú

Martins

Nachtigal

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…The distribution of genotypes found in this region of the country was similar to those found earlier in Hungary [16,17] and the Czech Republic, another country in Central Europe [27]. …”

Section: Discussionsupporting

confidence: 62%

“…We noticed that in our study the TTV prevalence in the saliva of controls (13.8%) was comparable with the TTV positivity rate of sera derived from healthy individuals (20/108; 18.5%) observed in a previous study performed using the same seminested PCR assay in Hungary [16]. Although the HNCC patient group and the controls were not age matched in the present study, we do not think that age had a significant impact on TTV prevalence, because others observed no significant difference in TTV prevalence between consecutive age groups above 30 years of age [25,26,27]. Our data suggest that TTV may replicate in certain HNCC neoplasms and oral precancerous lesions and it is transmitted to the saliva of the patients.…”

Section: Discussioncontrasting

confidence: 49%

Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients

Hettmann¹,

Demcsák²,

Bach³

et al. 2016

Intervirology

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Objectives: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. Methods: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used. Results: TTV prevalence was higher in HNCC patients (saliva: 27/71, 38%; tumor biopsy: 22/74, 30%) than in controls (saliva: 8/56, 14%; oral mucosa: 1/19, 5%). TTV prevalence was also high in patients with premalignant lesions of oral carcinoma (saliva: 9/18, 50%; biopsy: 5/21, 24%). By phylogenetic analysis, TTV belonging mostly to genotypes 1 and 2 was found in HNCC patients. In most of the cases, identical TTV strains were present in the biopsy and salivary sample of the same HNCC patient. In addition, the same TTV strain was detected in 2 laryngeal carcinoma biopsies obtained from 2 independent patients. Conclusions: Our data are compatible with the idea that TTV might act as a cocarcinogen in certain cases of HNCC. Alternatively, HNCC may facilitate either TTV replication or TTV entry into the saliva.

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“…Further more, variation in the TTV prevalence in children from 5.1% in Japan [49] to 54% in the Democratic Republic of Congo [50] is also suggestive of the possible involvement of some specific environmental factors in the acquisition of TTV infection. The sexual mode of transmission is likely of low effectiveness [51] .…”

Section: Human Transmissionmentioning

confidence: 99%

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

Irshad¹,

Yk²,

Dhar³

2006

WJG

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The present review gives an updated overview of transfusion transmitted virus (TTV), a novel agent, in relation to its molecular characteristics, epidemiological features, modes of transmission, tissue tropism, pathogenesis, role in various diseases and its eradication from the body. TTV, a DNA virus, is a single stranded, non-enveloped, 3.8 kb long DNA virus with a small and covalently closed circular genome comprising 3852 bases. It was tentatively designated Circinoviridae virus.TTV genome sequence is heterogeneous and reveals the existence of six different genotypes and several subtypes. TTV has been reported to transmit not only via parenteral routes, but also via alternate routes. This virus has been detected in different non-human primates as well. At present, TTV is detected by polymerase chain reaction (PCR) with no other available diagnostic assays. It shows its presence globally and was detected in high percent populations of healthy persons as well as in various disease groups. Initially it was supposed to have strong association with liver disease; however, there is little evidence to show its liver tropism and contribution in causing liver diseases. It shows high prevalence in hemodialysis patients, pointing towards its significance in renal diseases. In addition, TTV is associated with several infectious and non-infectious diseases. Although its exact pathogenesis is not yet clear, TTV virus possibly resides and multiplies in bone marrow cells and peripheral blood mononuclear cells (PBMCs). Recently, attempts have been made to eradicate this virus with interferon treatment. More information is still needed to extricate various mysteries related to TTV.

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Age-specific prevalence, transmission and phylogeny of TT virus in the Czech Republic

Cited by 32 publications

References 40 publications

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

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