Age trend of the male to female sex ratio in surgical gastric cancer patients at a single institution

Yu, Junxiu; He, Yongjun; Guo, Zhen

doi:10.1186/1477-7819-12-269

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…Similar results were found in a previous study of patients with gastric cancer > 85 years old compared to those 75–84 years of age [31]. The ratio of males to females with gastric cancer was the least at the age of 35, increased with age, peaked at the age of 60, decreased up to the age of 75, and remained around that level at the age of 80–85 [32].…”

Section: Discussionsupporting

confidence: 89%

Influence of age on postoperative complications especially pneumonia after gastrectomy for gastric cancer

et al. 2019

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Background The aim of this study was to investigate the influence of patients’ age on postoperative morbidities including pneumonia. Methods We reviewed the clinical records of 211 patients with stages I – III gastric cancer undergoing curative distal gastrectomy (DG) or total gastrectomy (TG). Patients were classified into an elderly (≧80 y.o.) or a control (< 80 y.o.) group. We compared patient characteristics (sex ratio, disease stage, degree of lymph node dissection, number of retrieved lymph nodes, and type of reconstruction) and early postoperative outcomes (operation time, intra-operative blood loss, and postoperative morbidity including pneumonia, and mortality) between the two groups separately in DG and TG. Results There were 134 and 77 patients who underwent DG and TG, respectively. The numbers of patients in the elderly and control groups were 25 and 109 in DG and 12 and 65 in TG. The percentage of female patients in the elderly group was greater than that in the control group in both DG and TG. The extent of lymph node dissection did not differ between two groups in TG; in contrast in DG, the rate of a D1 dissection was greater in the elderly group than in the control group. There were no differences between the two groups in distribution of disease stage, number of retrieved lymph nodes, operation time, and blood loss in DG and in TG. Overall postoperative morbidity did not differ between two groups after DG and after TG. The rate of infectious complications in the elderly group was not different from that in the control group after DG and after TG. The incidence of pneumonia was more frequent in the elderly group compared to the control group after DG (8% vs. 1%, P < 0.05) but not after TG (17% vs. 5%). When patients were compared between the elderly and the control groups regardless of type of gastrectomy, the incidence of pneumonia in the elderly group (4/37 (11%)) was greater than that in the control group (4/174 (2%), P < 0.05). Conclusions These results suggest that pneumonia is increased in patients older than 80 years after DG.

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Section: Discussionsupporting

confidence: 89%

Influence of age on postoperative complications especially pneumonia after gastrectomy for gastric cancer

et al. 2019

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“…Consequently, we could identify the early pathogenesis of gastric IMN by comparing data for MIMNs with conventional data for non-MIMNs with a diameter of more than 10 mm. Previous studies have shown that there are clear sex differences in GC between men and women, with most cases occurring in men [30]. In the present study, however, the relative ratio of men to women was significantly higher in MIMN than in non-MIMN.…”

Section: Discussioncontrasting

confidence: 88%

Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia

et al. 2019

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Background/Aims: To evaluate gastric early differentiatetype carcinogenesis, we attempted to identify clinicopathological and biological differences in differentiated-type minute intramucosal neoplasia (MIMN), which was defined as a tumor with a diameter of < 5 mm. Methods: We examined clinicopathological findings and biological factors, including TP53 overexpression, mucin phenotype, Ki-67-positive rate, MLH1, intranuclear accumulation of β-catenin, and DNA methylation status (low methylation epigenotype [LME], intermediate methylation epigenotype, and high methylation epigenotype [HME]) in MIMNs. In addition, non-MIMNs were also analyzed. In the present study, MIMN and non-MIMN were also examined based on low-grade dysplasia, highgrade dysplasia, and intramucosal cancer (IMC). Results: In clinicopathological findings, there were significant differences in sex ratios and tumor locations between MIMNs and non-MIMNs. Among the examined biological factors, no significant differences in the frequencies of biological factors were observed between the 2 intramucosal neoplasia types. However, the frequency of intranuclear accumulation of β-catenin was higher in non-MIMNs than in MIMNs. Finally, although the frequency of HME was significantly lower in MIMNs than in non-MIMNs, the opposite was observed for LME. Conclusions: The current finding suggested that DNA methylation and accumulation of β-catenin were closely associated with tumor development from MIMN to non-MIMN.

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“…Yu et al in their study found that the percentage of female cases gradually decreased with age whereas that of the male cases were reverse. [11] Janssen et al in their study found no difference in the rates of diffuse gastric carcinoma between the sexes. However, the rate of male patients with intestinal type carcinomas was more than twice as high as that of women.…”

Section: Discussionmentioning

confidence: 82%

CDX2 Expression in Gastric Carcinoma: A Clinicopathological Study

Halder

Kundu

Das

et al. 2018

Indian Journal of Medical and Paediatric Oncology

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Background: Gastric cancer accounts for 7.8% of cancers worldwide and adenocarcinoma is the commonest histological type. Both gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas. CDX2 is an intestinal transcription factor, which can be demonstrated in intestinal metaplasia and gastric carcinomas of the intestinal type. Unlike colorectal carcinomas, the role of CDX2 in gastric carcinomas as a prognostic variable is yet to be established. Ki-67 is a transcription factor expressed in the growth and synthetic phases of the cell cycle. Aims and Objectives: The aims of the study were to analyze CDX2 expression and Ki-67 labeling index in different histological types of gastric carcinomas and their relationship with the patients' clinicopathological parameters. Materials and Methods: A total of 50 gastric carcinoma cases were evaluated histologically and phenotypically, along with assessment of CDX2 expression and Ki-67 labeling index. Gastric carcinomas were grouped into intestinal and diffuse types, according to Lauren classification. A semiquantitative microscopic evaluation of CDX2 expression and Ki-67 labeling index was performed and correlated with the patients' clinicopathological parameters. Results: Increased CDX2 expression correlated with higher proportion of intestinal type gastric carcinomas and a lower proportion of lymph node metastasis, lymphovascular and perineural invasion. On the other hand, high Ki-67 labeling index was found in high grade tumors with lymphovascular invasion. Conclusions: The results of our study suggest that CDX2 might be a useful marker in predicting the prognosis of patients with gastric carcinoma. Accordingly, Ki-67 index seems to be useful in identifying a group of patients with aggressive tumors.

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Age trend of the male to female sex ratio in surgical gastric cancer patients at a single institution

Cited by 10 publications

References 18 publications

Influence of age on postoperative complications especially pneumonia after gastrectomy for gastric cancer

Influence of age on postoperative complications especially pneumonia after gastrectomy for gastric cancer

Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia

CDX2 Expression in Gastric Carcinoma: A Clinicopathological Study

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