Ageing and Duodenal Mucosal Immunity

Penn, N. D.; Purkins, Lynn; Kelleher, J.; Heatley, R. V.; Mascie‐Taylor, B H

doi:10.1093/ageing/20.1.33

Cited by 20 publications

(8 citation statements)

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“…Although the serum IgA levels are elevated in the elderly, these titers reflect the level of monomeric, non-Jchain-containing IgA that does not bind to the polymeric immunoglobulin receptor (pIgR) and is not transported to the mucosal surface as secretory IgA (Ebersole et al, 1985;Penn et al, 1991). There are no age-related differences in the nonspecific immunoglobulin titers in the intestinal lumen, either in vivo or in the medium of cultured duodenal biopsies (Arranz and Ferguson, 1992;Ginaldi et al, 2001).…”

Section: Aging and Intestinal Immunitymentioning

confidence: 99%

Basis for the Age‐related Decline in Intestinal Mucosal Immunity

Schmucker

Owen

Outenreath

et al. 2003

Journal of Immunology Research

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The elderly are characterized by mucosal immunosenescence and high rates of morbidity and mortality associated with infectious diseases of the intestinal tract. Little is known about how the differentiation of immunoglobulin A (IgA) plasma cells in Peyer's patches (PPs) and their subsequent homing to the small intestinal lamina propria (LP) is affected by aging. Quantitative immunohistochemical analyses demonstrated a 2-fold increase in the number of IgA þ cells in the PPs, coupled with significant declines in the numbers of IgA þ and antibody-positive cells in the intestinal LP of senescent rats compared to young adult animals. These data suggest that aging diminishes the emigration of IgA immunoblasts from these lymphoid aggregates, as well as their migration to the intestinal LP. Flow cytometry and lymphocyte adoptive transfer studies showed 3-to 4-fold age-related declines in the homing of antibody-containing cells and mesenteric lymph node lymphocytes to the small intestines of rhesus macaques and rats, respectively. The number of peripheral blood IgA immunoblasts expressing the homing molecule a4b7 declined 30% in senescent rats. This was accompanied by a .17% decrease in the areal density of LP blood vessels staining positive for the cell adhesion molecule MAdCAM-1. Cumulatively, declines in expression of these homing molecules constitute a substantial age-related diminution of IgA immunoblast homing potential. In vitro antibody secretion by LP plasma cells, i.e. antibody secreted per antibody-positive cell, remains unchanged as a function of donor age. Intestinal mucosal immunosenescence is a consequence of reduced homing of IgA plasma cells to the intestinal LP as a result of declines in homing molecule expression.

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Section: Aging and Intestinal Immunitymentioning

confidence: 99%

Basis for the Age‐related Decline in Intestinal Mucosal Immunity

Schmucker

Owen

Outenreath

et al. 2003

Journal of Immunology Research

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“…Serum IgG and IgM levels were reduced in their study in this group. No age-related differences were detected in the iiz vitro synthesis of immunoglobulins by duodenal biopsy tissues from young and old donors (148). Old rhesus monkeys immunized intraduodenally with cholera toxin produced lower levels of secretory IgA antibody to cholera toxin than young monkeys, whereas the total IgA levels in gut lavage samples were the same for the young and old animals (190).…”

Section: Mucosal Immunitymentioning

confidence: 99%

Effect of aging on immunocompetent and inflammatory cells

McArthur¹

1998

Periodontology 2000

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“…Despite evidence of mucosal immunodeficiency, serum IgA levels are elevated in the elderly as compared with younger controls [31, 32], but these IgA are predominantly monomeric IgA which are not transported to the mucosal surface as sIgA [81]. Conversely, no age-related differences in total Ig titers in the intestinal lumen or in the cultures of duodenal biopsies have been reported [82].…”

Section: Introductionmentioning

confidence: 99%

Aging Affects Human B Cell Responses

2011

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Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

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Ageing and Duodenal Mucosal Immunity

Cited by 20 publications

References 0 publications

Basis for the Age‐related Decline in Intestinal Mucosal Immunity

Basis for the Age‐related Decline in Intestinal Mucosal Immunity

Effect of aging on immunocompetent and inflammatory cells

Aging Affects Human B Cell Responses

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