Ageing and neurodegenerative diseases

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

“…Age-related disorders such as Alzheimer's disease and brain ischemia represent a major clinical problem in developed countries [18,28,41] and are a major economic burden for health care systems [15,37]. Dietary, genetic and molecular factors are important determinants in progression and treatment of the above diseases [1,[47][48][49][50][51]53].…”

Neurodegeneration and Ageing: A Fatal Encounter

“…Interestingly, rate of ageing varies between individuals and groups, as well as among different systems, organs and cells within the individuals itself. Physiological changes like increased accumulation of toxic metabolic products and cell damage expose the organism to many kinds of diseases and eventually, they become susceptible to many age dependent diseases where neurodegenerative disorders and cancers pose as major threats [39]. Among the age related disorders, neurodegenerative disorders emerged as an essential area in neurobiology because of disease irreversibility and lack of effective treatment.…”

Therapeutic Potential of Polyphenols in Parkinson’s Disease

“…It has been hypothesized that by activating SIRT1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFB (Pallas et al, 2009). The beneficial effects of resveratrol as an anti-aging compound are believed to be mediated via the activation of SIRT1 (Hung et al, 2010). Resveratrol administration in adult mice protected the SN dopaminergic neurons and striatal dopamine against the neurotoxic effects of MPTP (Anderson et al, 2006, Blanchet et al, 2008.…”