Agenesis of ductus venosus in sequential first and second trimester screening

Iliescu, Dominic Gabriel; Cara, M.; Tudorache, Ş.; Antsaklis, Panagiotis; Novac, Liliana; Antsaklis, Aris; Cernea, N.

doi:10.1002/pd.4434

Cited by 22 publications

(25 citation statements)

References 36 publications

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“…The exact etiology of ADV is unclear, and it may result from primary agenesis and/or functional or structural closure. Usually, ADV can be detected during the early scan of the first trimester evaluation [85], but in some cases, the ultrasound scan is reported as normal in early pregnancy; there can be a missed diagnosis, but another explanation is the formation of a secondary closure due to an unknown gradual condition [86]. ADV can appear associated with varying comorbidities, some of which are incompatible with life: cardiomegaly, chromosomopathies, altered fetal growth and hepatic calcifications [87].…”

Section: Agenesis Of the Ductus Venosusmentioning

confidence: 99%

“…However, if there was no evidence of hydrops and cardiac overload associated with the ADV, the survival rate was 100%, regardless of the type of ADV [84]. In fact, many studies report a good outcome when there is no further pathological finding, as chromosomopathy or hydrops [84,85,88]. Fetuses with ADV and restrictive alternative umbilical venous pathways may have a more benign clinical course because the "small shunt" is unlikely to induce cardiac failure [88].…”

Section: Agenesis Of the Ductus Venosusmentioning

confidence: 99%

“…Fetuses with ADV and restrictive alternative umbilical venous pathways may have a more benign clinical course because the "small shunt" is unlikely to induce cardiac failure [88]. Not only the caliber of the shunt but also the NT thickness seems to be important in the evaluation of the prognosis, unless ADV appears isolated [85,88].…”

Section: Agenesis Of the Ductus Venosusmentioning

confidence: 99%

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Clinical Significance of Ductus Venosus Waveform as Generated by Pressure- volume Changes in the Fetal Heart

Braga

Moleiro

Guedes-Martins

2019

CCR

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The ductus venosus is a vascular shunt situated within the fetal liver parenchyma, connecting the umbilical vein to the inferior vena cava. This vessel acts as a bypass of the liver microcirculation and plays a critical role in the fetal circulation. The ductus venosus allows oxygenated and nutrient-rich venous blood to flow from the placenta to the myocardium and brain. Increased impedance to flow in the fetal ductus venosus is associated with fetal aneuploidies, cardiac defects and other adverse pregnancy outcomes. This review serves to improve our understanding of the mechanisms that regulate the blood flow redistribution between the fetal liver circulation and fetal heart and the clinical significance of the ductus venosus waveform as generated by pressure-volume changes in the fetal heart.

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Section: Agenesis Of the Ductus Venosusmentioning

confidence: 99%

Section: Agenesis Of the Ductus Venosusmentioning

confidence: 99%

Section: Agenesis Of the Ductus Venosusmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Significance of Ductus Venosus Waveform as Generated by Pressure- volume Changes in the Fetal Heart

Braga

Moleiro

Guedes-Martins

2019

CCR

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“…La agenesia del ductus venoso (ADV) es una anomalía poco frecuente cuya prevalencia se estima que en 1/2500 gestaciones, aunque esta cifra disminuye en los centros de referencia aproximadamente de 1 en 556 (70).…”

Section: Agenesia Del DVunclassified

Ultrasound evaluation of the fetal venous ductus and its clinical applications in the current Obstetrics

Cosp

2018

An. Fac. Cienc. Méd. (Asunción)

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“…However, in spite of the new and better technologies, this is still a rare condition with a reported prevalence of 1 in 2532 [7] and 1 in 556 foetuses [8], and with a variable prognosis that relies partly on the presence of associated conditions.…”

Section: Issn: 2637-4617mentioning

confidence: 99%

Ductus Venosus Agenesis and Fetal Malformations: Report of Four Cases

Matias

Pacheco

Brandão

et al. 2018

COGO

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Background: The agenesis of the ductus venosus (DVA) is a rare condition with a variable prognosis that relies partly on the presence of associated conditions. Therefore, the prenatal evaluation should include a careful examination of fetal circulation, particularly the umbilical and portal venous malformations.Methods In this study, we describe four cases of DVA diagnosed at our institution. For each case, we access the patient’s files in order to extract the following information: gestational age, umbilical vein connection, pre-natal imaging findings, gestational age at delivery or at pregnancy termination, fetal outcomes, post-natal imaging findings, post-mortem findings and karyotype.Results From the four cases included, two were diagnosed in the first trimester and the other two cases in the second trimester of gestation. Prenatal ultrasound studies revealed an intrahepatic shunt in one case and an extrahepatic shunt in three cases. In one case, the karyotype was not performed, whereas the other three had a normal karyotype. Cardiac anomalies were found in three of the four fetuses. All but one case presented with extracardiac abnormalities. None of the cases developed hydrops. Two cases are currently alive and well, one termination of pregnancy occurred at 25 weeks of gestation and one case died at 14 days during surgical correction of a complex cardiac malformation.Conclusions Clinicians should be aware of different and important findings during the fetal examination, which can be indicative of a DVA, and, when suspected, serial revaluations should be scheduled in order to identify any malformation.

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Agenesis of ductus venosus in sequential first and second trimester screening

Abstract: Agenesis of the ductus venosus can be detected during FT. The early detection of ADV is important given its high association with major abnormalities.

Cited by 22 publications

References 36 publications

Clinical Significance of Ductus Venosus Waveform as Generated by Pressure- volume Changes in the Fetal Heart

Clinical Significance of Ductus Venosus Waveform as Generated by Pressure- volume Changes in the Fetal Heart

Ultrasound evaluation of the fetal venous ductus and its clinical applications in the current Obstetrics

Ductus Venosus Agenesis and Fetal Malformations: Report of Four Cases

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