Objective To evaluate intra-and interobserver agreement for first-trimester fetal cardiac structural assessment, using two-dimensional (2D) 2D and 4D methods (kappa > 0.6) Results STIC volumes were considered satisfactory (adequate visualization of at least 8/11 parameters) in 78% of cases and 2D-US acquisitions in 89% of cases. The intra-and interobserver agreement was good for both

Agenesis of the ductus venosus can be detected during FT. The early detection of ADV is important given its high association with major abnormalities.

Short oral presentation abstractsin ovine twin fetuses. The intensified release of neurotransmitters and subsequent increase of cerebral Doppler indices indicates a neuroprotective response to prolonged hypoxia with primary expected brain damages and osmotic imbalances. OP05: FIRST TRIMESTER ULTRASOUND: BEYOND NT OP05.01Only seeing what you look for: use of a detailed ultrasound protocol is associated with increased anomaly detection rates in the first trimester Objectives: First trimester ultrasound is routinely performed for chromosomal abnormality screening and is increasingly becoming a tool for the detection of fetal structural anomalies. The aim was to perform a systematic review and meta-analysis of studies assessing the detection rate of first trimester anomaly detection and to determine which factors impact rates of detection. Methods: An electronic search was conducted to identify publications assessing diagnostic accuracy of first trimester two-dimensional ultrasound for the detection of fetal structural anomalies. Sub-group analysis was performed assessing studies within one of three categories: (1) Studies reporting on major anomalies in an unselected population; (2) Studies assessing all types of anomalies in an unselected population; and (3) Studies examining all types of anomalies in high risk populations. Results: In unselected populations first trimester ultrasound had a sensitivity of 36.1% (95% C.I. 33.2-39.0) for major anomalies and was responsible for 57.1% of antenatal diagnoses. In an unselected population assessed for all types of anomalies the sensitivity was lower 33.3% (95% C.I. 31.1-35.5) while in high-risk populations it was 62.3% (95% C.I. 54.6-70.2). There was a statistically significant correlation between the use of an anatomical protocol for screening and detection rates (P < 0.0001). The use of a detailed protocol, compared to a basic protocol, also improved sensitivity (P < 0.0001). Conclusions: First trimester anomaly screening will lead detects about one third of fetal anomalies in unselected populations and two-thirds in high risk populations. It allows detection of a significant number of severe fetal anomalies at an earlier stage than is currently standard practice. Evidence suggests that the use of a detailed anatomical protocol could improve this further. OP05.02Fetal kidneys' ultrasound appearance in the first trimester

IntroductionOver the last decades, a large body of literature has shown that intrapartum clinical digital pelvic estimations of fetal head position, station and progression in the pelvic canal are less accurate, compared with ultrasound (US) scan. Given the increasing evidence regarding the advantages of using US to evaluate the mechanism of labour, our study protocol aims to develop sonopartograms for fetal cephalic presentations. They will allow for a more objective evaluation of labour progression than the traditional labour monitoring, which could enable more rapid decisions regarding the mode of delivery.Methods/analysisThis is a prospective observational study performed in three university hospitals, with an unselected population of women admitted in labour at term. Both clinical and US evaluations will be performed assessing fetal head position, descent and rotation. Specific US parameters regarding fetal head position, progression and rotation will be recorded to develop nomograms in a similar way that partograms were developed. The primary outcome is to develop nomograms for the longitudinal US assessment of labour in unselected nulliparous and multiparous women with fetal cephalic presentation. The secondary aims are to assess the sonopartogram differences in occiput anterior and posterior deliveries, to compare the labour trend from our research with the classic and other recent partogram models and to investigate the capability of the US labour monitoring to predict the outcome of spontaneous vaginal delivery.Ethics and disseminationAll protocols and the informed consent form comply with the Ministry of Health and the professional society ethics guidelines. University ethics committees approved the study protocol. The trial results will be published in peer-reviewed journals and at the conference presentations. The study will be implemented and reported in line with the Strengthening the Reporting of Observational Studies in Epidemiology statement.Trial registration numberClinicalTrials.gov Registry (NCT02326077).