Agenesis of the inferior vena cava associated with lower extremities and pelvic venous thrombosis

Gil, Roberto Jiménez; Pérez, Alberto Miñano; Arias, Jorge Bercial; Pascual, F. Bernabeu; Romero, Eugenio Sansegundo

doi:10.1016/j.jvs.2006.06.021

Cited by 66 publications

(56 citation statements)

References 20 publications

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“…There are some reports of recurrence of thrombosis after discontinuation of the treatment [12]. The treatment was conducted according with clinical evolution and serial ultrasound aspects.…”

Section: Discussionmentioning

confidence: 99%

Deep Venous Thrombosis Associated With Inferior Vena Cava Abnormalities And Hypoplastic Kidney In Siblings

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Simu

et al. 2016

Acta Medica Marisiensis

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Congenital inferior vena cava anomalies have a reduced frequency in general population, many times being an asymptomatic finding. Patients caring such anomalies are at risk to develop deep vein thrombosis. In this paper, we present 2 siblings with deep venous thrombosis and inferior vena cava abnormalities, with a symptomatic onset at similar age. The inferior vena cava abnormality was documented by an angio-CT in each case. The thrombophilic workup was negative. Patients were treated with conservative therapy: low molecular weight heparin anticoagulants converted later to oral anticoagulant with resolution of symptoms and disappearance of the thrombus. Finally, in the absence of any risk factor in a young patient admitted with deep vein thrombosis investigations to exclude inferior vena cava anomalies are mandatory.

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Section: Discussionmentioning

confidence: 99%

Deep Venous Thrombosis Associated With Inferior Vena Cava Abnormalities And Hypoplastic Kidney In Siblings

Duicu

Bucur

Simu

et al. 2016

Acta Medica Marisiensis

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“…12) In most of the DVT cases with IVC anomaly, conventional anticoagulation therapy with warfarin has been used to relieve the symptoms. 6,[13][14][15] As the patients who experienced thrombosis due to IVC anomaly may have a higher risk for thrombotic recurrence, lifelong anticoagulation therapy should be considered. 15,16) Recently, direct oral anticoagulants (DOACs) have been developed as alternatives to the conventional therapy with warfarin for the treatment of acute venous thromboembolism events.…”

Section: Discussionmentioning

confidence: 99%

“…6,[13][14][15] As the patients who experienced thrombosis due to IVC anomaly may have a higher risk for thrombotic recurrence, lifelong anticoagulation therapy should be considered. 15,16) Recently, direct oral anticoagulants (DOACs) have been developed as alternatives to the conventional therapy with warfarin for the treatment of acute venous thromboembolism events. [17][18][19][20][21][22][23] Nevertheless, the clinical efficiency for DOACs for patients with IVC anomalies remains unclear.…”

Section: Discussionmentioning

confidence: 99%

A Pitfall in the Diagnosis of Bilateral Deep Vein Thrombosis in a Young Man

et al. 2018

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SummaryA 32-year-old man with a history of bronchial asthma was referred for low back pain and bilateral femur pain. Vascular sonography revealed bilateral deep vein thrombosis (DVT) from the femoral veins to the popliteal veins. Computed tomography revealed hypoplasia of the inferior vena cava (IVC) and dilated lumbar veins, ascending lumbar veins, and azygos vein as collaterals. There was no evidence of malignant neoplasm. The results of the thrombophilia tests were within normal limits. Hypoplasia of the IVC is a rare cause of DVT. This anomaly should be considered as a cause of bilateral and proximal DVT, in particular, in young patients without major risk factors.(Int Heart J 2018; 59: 451-454) Key words: Venous thromboembolism, Azygos continuation, Anomaly, Computed tomography T he average annual incidence of deep vein thrombosis (DVT) is estimated about 1 per 1000 in developed countries.1-3) The incidence of DVT increases exponentially with age.1) DVT has a multifactorial etiology associated with both acquired and congenital factors, which may induce hypercoagulability or venous stasis.4) When there are no major risk factors for DVT, such as hospital or nursing home confinement, surgery, trauma, malignant neoplasm, chemotherapy, or neurologic disease with paresis, 5) further investigation including congenital factors should be implemented, in particular, in young patients. In this case report, we present a young man with DVT, and discuss the cause of his DVT. Case ReportA 32-year-old man with a history of bronchial asthma was referred for low back pain and bilateral femur pain. He had no fever or dyspnea. His vital signs in the emergency room remained within normal limits with blood pressure of 105/64 mmHg, pulse rate of 85 beats/ min, and pulse-oximetry oxygen saturation of 100% in ambient air. Laboratory data revealed elevated white blood cell counts (12,300/μL), CRP levels (13.6 mg/dL), and Ddimer levels (30.2 μg/mL). The patient had a 12-hourflight, 1 week before the presentation. Observations revealed bilateral leg edemas with dermatitis and pigmentation of bilateral femurs. Vascular sonography revealed bilateral DVT from the femoral veins to the popliteal veins. Although he revealed a history of bronchial asthma, we performed contrast enhanced computed tomography (CT) with prophylactic administration of intravenous corticosteroids in order to investigate the cause of his bilateral DVT. The CT denied aortic dissection or pulmonary embolism; however, it revealed hypoplasia of the inferior vena cava (IVC) and bilateral DVT. Transverse views of the CT images are presented in Figure 1 (A; Th12 level, B; L1 level, C; L2 level, D; L3 level) and Figure 2A (L4 level), which reveal hypoplasia of the IVC (yellow arrows) and collateral veins (red arrows; dilated lumbar vein, blue arrows; ascending lumbar vein). Figure 2B is a coronal multiplanar reconstruction view of CT images, which emphasizes on the IVC filled with thrombi at the level of L2-L4 (arrows). Figure 2C is a sagittal multiplanar reconstruction vie...

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“…Other congenital problems are rarer still, but agenesis of vessels (such as the inferior vena cava 13 ) form a significant proportion of these, and can manifest themselves as other disease states such as venous thromboembolic (VTE) disease.…”

Section: Congenital Venous Diseasesmentioning

confidence: 99%