Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

Sun, Wei; Zeng, Chaorong; Liu, Shanshan; Fu, Jie; Hu, Liwen; Shi, Zhen; Dong, Yue; Ren, Zhihua; Zhong, Zhijun; Zuo, Zhicai; Cao, Suizhong; Peng, Guangneng; Deng, Junliang; Hu, Yanchun

doi:10.1038/s41598-018-34492-7

Cited by 41 publications

(32 citation statements)

References 44 publications

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“…According to previous studies, ROS serves as the trigger of the NLRP3 inflammasome [53]. Cisplatin activates NLRP3 inflammasome expression and releases proinflammatory cytokines, thereby resulting in acute injury to the liver and kidneys in rats [22].…”

Section: Gapdh Normentioning

confidence: 96%

The Antiemetic Effect of Xiao‐Ban‐Xia‐Tang Formula against Cisplatin‐Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model

Meng

Cheng

Feng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Xiao-Ban-Xia-Tang (XBXT), a traditional Chinese medicine formula, has been used for the treatment of emesis for nearly 2000 years, but its underlying mechanism is not yet fully clarified. The purpose of this study is to reveal the antiemetic mechanisms of XBXT by focusing on the NLRP3 inflammasome pathway in a chemotherapy-induced rat pica model. The pica model was generated by a single intraperitoneal injection of cisplatin in this study. Consumption of kaolin (a type of clay) and food and body weight were recorded every 24 hours. Cisplatin-induced increase in kaolin consumption (pica) was used to quantify chemotherapy-induced nausea and vomiting (CINV). Tissue from the ileum and antrum was stained with hematoxylin eosin (HE) to observe pathological changes. The levels of reactive oxygen species (ROS) and inflammatory cytokines, including IL-1β and IL-18 in serum, were detected by ELISA. In addition, changes in the NLRP3 inflammasome activation in the ileum and antrum were investigated using western blot and immunofluorescence microscopy. The results showed that oral administration of XBXT and ondansetron inhibited acute and delayed pica and significantly protected against the gastrointestinal pathological injury induced by cisplatin. The levels of ROS, IL-1β, and IL-18 in the serum of cisplatin-treated rats were also remarkably decreased by XBXT and ondansetron. Moreover, we found that XBXT can inhibit cisplatin-induced NLRP3 inflammasome activation. The present study indicates that the inhibition of the NLRP3 inflammasome activation might be one of the potential mechanisms for the therapeutic effects of XBXT against CINV.

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Section: Gapdh Normentioning

confidence: 96%

The Antiemetic Effect of Xiao‐Ban‐Xia‐Tang Formula against Cisplatin‐Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model

Meng

Cheng

Feng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The mtDNA can be damaged oxidatively by ROS (Larosche et al, 2010). Our recent study showed that ROS was elevated by A. adenophora in mice liver (Sun et al, 2018). However, no studies have been reported on the effect of hepatopathy induced by A. adenophora in hepatic mtDNA.…”

Section: Fig 1 Histopathological Observation Of In the Liver Sectionmentioning

confidence: 99%

Involvement of mitochondrial dysfunction in hepatotoxicity induced by Ageratina adenophora in mice

Sun

Zeng

Dong

et al. 2019

J. Zhejiang Univ. Sci. B

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Ageratina adenophora is a noxious plant and it is known to cause acute asthma, diarrhea, depilation, and even death in livestock (Zhu et al., 2007; Wang et al., 2017). A. adenophora grows near roadsides and degraded land worldwide (He et al., 2015b). In the areas where it grows, A. adenophora is an invasive species that inhibits the growth of local plants and causes poisoning in animals that come in contact with it (Nie et al., 2012). In China, these plants can be found in Yunnan, Sichuan, Guizhou, Chongqing, and other southwestern areas (He et al., 2015a) and they have become a dominant species in these local regions. It threatens the native biodiversity and ecosystem in the invaded areas and causes serious economic losses (Wang et al., 2017). It has been reported that A. adenophora can grow in the northeast direc

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“…Reactive oxygen species (ROS) such as hydrogen peroxide and hydroxyl ions are created through the reduction of oxygen during molecular processes. ROS play an important role in both pyroptosis and necroptosis [54][55][56][57][58][59][60]. In pyroptosis, ROS commonly serve as the second signal leading to inflammasome activation, which forms as a precursor to caspase-1 activation, Gasdermin D cleavage, and subsequent membrane rupture.…”

Section: Role Of Ros In Rsv-induced Lytic Cell Deathmentioning

confidence: 99%

Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis

Bedient

Pokharel

Chiok

et al. 2020

Viruses

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Human respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in infants and children worldwide. Inflammation induced by RSV infection is responsible for its hallmark manifestation of bronchiolitis and pneumonia. The cellular debris created through lytic cell death of infected cells is a potent initiator of this inflammation. Macrophages are known to play a pivotal role in the early innate immune and inflammatory response to viral pathogens. However, the lytic cell death mechanisms associated with RSV infection in macrophages remains unknown. Two distinct mechanisms involved in lytic cell death are pyroptosis and necroptosis. Our studies revealed that RSV induces lytic cell death in macrophages via both of these mechanisms, specifically through the ASC (Apoptosis-associated speck like protein containing a caspase recruitment domain)-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome activation of both caspase-1 dependent pyroptosis and receptor-interacting serine/threonine-protein kinase 3 (RIPK3), as well as a mixed lineage kinase domain like pseudokinase (MLKL)-dependent necroptosis. In addition, we demonstrated an important role of reactive oxygen species (ROS) during lytic cell death of RSV-infected macrophages.

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Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

Cited by 41 publications

References 44 publications

The Antiemetic Effect of Xiao‐Ban‐Xia‐Tang Formula against Cisplatin‐Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model

The Antiemetic Effect of Xiao‐Ban‐Xia‐Tang Formula against Cisplatin‐Induced Emesis is Mediated through Inhibition of NLRP3 Inflammasome Activation in a Rat Pica Model

Involvement of mitochondrial dysfunction in hepatotoxicity induced by Ageratina adenophora in mice

Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis

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