AGEs, contributors to placental bed vascular changes leading to preeclampsia

Guedes-Martins, Luís; Matos, Liliana; Soares, Ana Isabel; Silva, E.; Almeida, Henrique

doi:10.3109/10715762.2013.815347

Cited by 32 publications

(23 citation statements)

References 97 publications

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“…Previous studies demonstrated that serum AGEs in preeclamptic women were significantly higher than in healthy women. Accumulation of AGEs may induce oxidative injury and vascular perturbation in placental bed, leading to preeclampsia [55]. The study of Jeong et al showed that AGEs contribute to elevation of sFlt-1.…”

Section: Studies Performed In Humansmentioning

confidence: 99%

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Kniotek

Boguska

2017

Journal of Immunology Research

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Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a common regulator of ion channel conductance, glycogenolysis, and cellular apoptosis. PDE5 inhibitors (PDE-Is) found application in cardiology, nephrology, urology, dermatology, oncology, and gynecology. Positive result of sildenafil treatment is closely connected with its immunomodulatory effects. Sildenafil influences angiogenesis, platelet activation, proliferation of regulatory T cells, and production of proinflammatory cytokines and autoantibodies. Sildenafil action in humans and animals appears to be different. Surprisingly, it also acts differently in males and females organisms. Although the immunomodulatory effects of PDE5 inhibitors appear to be promising, none of them reached the point of being tested in clinical trials. Data on the influence of selective PDE5-Is on the human immune system are limited. The main objective of this review is to discuss the immunomodulatory effects of sildenafil in both patients and experimental animals. This is the first review of the current state of knowledge about the effects of sildenafil on the immune system.

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Section: Studies Performed In Humansmentioning

confidence: 99%

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Kniotek

Boguska

2017

Journal of Immunology Research

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“…Furthermore, NF-κB may induce tumor necrosis factor-α (TNF-α), which plays a pivotal role in endothelial dysfunction (Gao et al, 2008; Zhang, 2008). It seems that NF-κB-induced local inflammatory reaction may have important placental dysfunctional features, at least in pre-eclampsia (Guedes-Martins et al, 2013). Recent studies have demonstrated that similar oxygen-sensing mechanisms, such as hydroxylases, are determinants on oxygen sensitivity for both HIF and NF-κB-dependent gene expression.…”

Section: Hypoxia and Oxidative Stressmentioning

confidence: 99%

The placental pursuit for an adequate oxidant balance between the mother and the fetus

et al. 2014

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The placenta is the exchange organ that regulates metabolic processes between the mother and her developing fetus. The adequate function of this organ is clearly vital for a physiologic gestational process and a healthy baby as final outcome. The umbilico-placental vasculature has the capacity to respond to variations in the materno-fetal milieu. Depending on the intensity and the extensity of the insult, these responses may be immediate-, mediate-, and long-lasting, deriving in potential morphostructural and functional changes later in life. These adjustments usually compensate the initial insults, but occasionally may switch to long-lasting remodeling and dysfunctional processes, arising maladaptation. One of the most challenging conditions in modern perinatology is hypoxia and oxidative stress during development, both disorders occurring in high-altitude and in low-altitude placental insufficiency. Hypoxia and oxidative stress may induce endothelial dysfunction and thus, reduction in the perfusion of the placenta and restriction in the fetal growth and development. This Review will focus on placental responses to hypoxic conditions, usually related with high-altitude and placental insufficiency, deriving in oxidative stress and vascular disorders, altering fetal and maternal health. Although day-to-day clinical practice, basic and clinical research are clearly providing evidence of the severe impact of oxygen deficiency and oxidative stress establishment during pregnancy, further research on umbilical and placental vascular function under these conditions is badly needed to clarify the myriad of questions still unsettled.

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“…The demand for natural products to treat diabetes is increasing worldwide. More than 1,000 plant species are used as folk medicine for diabetes [100,101]. The chemical compositionbased biological actions of plant products used as alternative medicines for treating diabetes are related to each other.…”

Section: Herbal Medicines and Treatment Of Diabetesmentioning

confidence: 99%

Alternative Medicine in Diabetes - Role of Angiogenesis, Oxidative Stress, and Chronic Inflammation

Elrefaei¹,

Abduljawad²,

Alghamdi³

2014

Rev Diabet Stud

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■ AbstractDiabetes is a chronic metabolic disorder that is characterized by hyperglycemia due to lack of or resistance to insulin. Patients with diabetes are frequently afflicted with ischemic vascular disease and impaired wound healing. Type 2 diabetes (T2D) is known to accelerate atherosclerotic processes, endothelial cell dysfunction, glycosylation of extracellular matrix proteins, and vascular denervation. Herbal medicines and naturally occurring substances may positively affect diabetes management, and could thus be utilized as costeffective means of supporting treatment in developing countries. Natural treatments have been used in these countries for a long time to treat diabetes. The present review analyses the features of aberrant angiogenesis, abnormalities in growth factors, oxidative stress, and metabolic derangements relevant to diabetes, and how herbal substances and their active chemical constituents may counteract these events. Evidence for possible biochemical effectiveness and limitations of herbal medicines are given, as well as details regarding the role of cytokines and nitric oxide.

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AGEs, contributors to placental bed vascular changes leading to preeclampsia

Cited by 32 publications

References 97 publications

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

The placental pursuit for an adequate oxidant balance between the mother and the fetus

Alternative Medicine in Diabetes - Role of Angiogenesis, Oxidative Stress, and Chronic Inflammation

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