Agglutinins and Incomplete Antibodies after a Single Antigenic Inoculation in Normal and Rheumatic Individuals

Wagner, V.; Rejholec, V.; Malý, V.; Hallerova, E.; Motlikova, M; Repič-Šlechta, M.

doi:10.1136/ard.14.3.243

Cited by 16 publications

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References 14 publications

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“…There are exceptions, but, if rheumatics are considered as a group, this observation seems to hold true and it has led to an assumption that rheumatic individuals, that is, those who acquire rheumatic fever or are especially susceptible because one or both parents, a sibling or near relative has had rheumatic fever, respond in a different manner to streptococcal infections than non-rheumatic persons. The response of rheumatic and non-rheumatic subjects to antigenic stimuli has been the objective of several recent investigations (8)(9)(10)(11) none of which has shown any significant differences between rheumatics and non-rheumatics in their response to a variety of non-streptococcal antigens with the exception that when a strain of Brucella abortus was used as the antigen (12,13) rheumatic subjects developed higher levels of agglutinins and incomplete antibodies than normal persons. However, the more crucial question would seem to be: "Do rheumatics respond differently to streptococcal infections or antigens than non-rheumatics ?"…”

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The Response of Rheumatic and Non-Rheumatic Children to Streptolysin O Concentrate 1

Quinn¹

1957

J. Clin. Invest.

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The observation that individuals who acquire rheumatic fever following a streptococcal infection usually respond with higher streptococcal antibody titres than those who have streptococcal infections uncomplicated by rheumatic fever has been reported repeatedly (1-7). There are exceptions, but, if rheumatics are considered as a group, this observation seems to hold true and it has led to an assumption that rheumatic individuals, that is, those who acquire rheumatic fever or are especially susceptible because one or both parents, a sibling or near relative has had rheumatic fever, respond in a different manner to streptococcal infections than non-rheumatic persons. The response of rheumatic and non-rheumatic subjects to antigenic stimuli has been the objective of several recent investigations (8-11) none of which has shown any significant differences between rheumatics and non-rheumatics in their response to a variety of non-streptococcal antigens with the exception that when a strain of Brucella abortus was used as the antigen (12, 13) rheumatic subjects developed higher levels of agglutinins and incomplete antibodies than normal persons. However, the more crucial question would seem to be: "Do rheumatics respond differently to streptococcal infections or antigens than non-rheumatics ?" To conclude that rheumatic individuals respond with higher streptococcal antibody titres than non-rheumatics following a streptococcal infection because they are fundamentally different is open to a number of criticisms, one of which is that the dose of antigen in a streptococcal infection is unknown and it could be that some patients have higher antibody titres because they received a larger dose of antigen during the infection. It is the purpose of this paper to report an investigation of the problem of whether rheumatic individuals respond to equiva-1 This study was aided by a grant from the Life Insurance Medical Research Fund. lent doses of streptococcal antigens in a different manner than non-rheumatic individuals. METHODSPreparation of streptolysin 0 concentrate. A modification of a method for purification of streptolysin 0 by Herbert and Todd (14) was used to prepare the concentrated streptococcal antigens. The starting material was the filtrate from 5 to 6 litres of beef heart infusion broth prepared from fresh beef hearts, in which a strain of group A type 3 beta hemolytic streptococcus had grown for 18 hours at 37°C. Six lots of streptolysin 0 were prepared, the end-products of three preparations containing the most highly concentrated streptolysin 0 being combined. The steps in the purification procedure were the same as those outlined by Herbert and Todd with the exception that the final step of adsorption and elution from alumina C gamma gel was not performed.The final products were dry, fluffy, light tan to dark brown in color with some stickiness in two of the preparations. The yields were 26, 102, 35, 208, 187 and 280 mg.Test for streptolysin 0 combining power. Five mg.of streptolysin 0 concentrate were dissol...

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The Response of Rheumatic and Non-Rheumatic Children to Streptolysin O Concentrate 1

Quinn¹

1957

J. Clin. Invest.

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Über die Bedeutung von Streptokokkeninfektionen in der Pathogenese der akuten Polyarthritis und der akuten Neprithis

Christ¹

1959

Ergebnisse Der Inneren Medizin Und Kinderheilkunde

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Changes in T-lymphocyte subsets during acute rheumatic fever

et al. 1982

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Relative proportions and numbers of helper [OKT4(+)] and suppressor [OKT8(+)] peripheral blood lymphocytes were examined in 32 young patients during the acute phase of rheumatic fever. No significant decrease in percentage T cells during acute rheumatic fever was noted in comparison to normal children controls from the same population. A decrease in absolute numbers of OKT4(+) T cells was also noted in acute rheumatic subjects not receiving corticosteroids (P less than 0.05). In addition, a significant decrease was documented in both proportions and total numbers of OKT8(+) putative suppressor cells during acute rheumatic attacks. C-reactive protein binding to T-lymphocyte subsets showed no preferential reactivity in vivo for suppressor or helper T cells. Antigen-reactive T lymphocytes identified with the T29 mouse hybridoma reagent showed similar proportions and numbers in rheumatic children as were noted in controls. The present data indicate profound alterations in both helper- and suppressor-cell types in the peripheral blood profile of children with acute rheumatic fever.

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Agglutinins and Incomplete Antibodies after a Single Antigenic Inoculation in Normal and Rheumatic Individuals

Cited by 16 publications

References 14 publications

The Response of Rheumatic and Non-Rheumatic Children to Streptolysin O Concentrate 1

The Response of Rheumatic and Non-Rheumatic Children to Streptolysin O Concentrate 1

Über die Bedeutung von Streptokokkeninfektionen in der Pathogenese der akuten Polyarthritis und der akuten Neprithis

Changes in T-lymphocyte subsets during acute rheumatic fever

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