2022
DOI: 10.1002/agt2.162
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Aggregating particles on the O/W interface: Tuning Pickering emulsion for the enhanced drug delivery systems

Abstract: The rational design of drug delivery systems has led to enhanced targeting, increased efficiency, and a reduction of side effects in chemotherapies and vaccines. As most biological reactions took place at the interface, particle-stabilized emulsion (Pickering emulsion), may offer major implications for the advanced drug loading, delivery, and controlled release. In fact, it is the aggregating particles that determined the multi-level structure, multi-valent cellular interactions, and the multi-functional physi… Show more

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Cited by 32 publications
(14 citation statements)
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“…with siRNA than PAMD due to the decreased size distribution and increased zeta potential. [ 25‐27 ] By agarose gel electrophoresis and fluorescence quenching assays, the improved siRNA binding ability of PAMD/Zn was further verified (Figures 2A—B, Figure S2A). The TEM image showed PAMD/Zn NPs with spherical shapes (Figure 2C).…”
Section: Resultsmentioning
confidence: 78%
See 1 more Smart Citation
“…with siRNA than PAMD due to the decreased size distribution and increased zeta potential. [ 25‐27 ] By agarose gel electrophoresis and fluorescence quenching assays, the improved siRNA binding ability of PAMD/Zn was further verified (Figures 2A—B, Figure S2A). The TEM image showed PAMD/Zn NPs with spherical shapes (Figure 2C).…”
Section: Resultsmentioning
confidence: 78%
“…Inflammatory cells, including peripheral blood leukocytes and neutrophils, were first determined by the automatic hematology analyzer. [ 25,29‐30 ] As shown in Figure 3B, these inflammatory cells had a remarkable increase in…”
Section: Resultsmentioning
confidence: 88%
“…1,2 Pickering emulsions that are responsive to multiple stimuli have a wider range of applications and future prospects. 3,4 Microgels are a class of polymer particles that have distinctive interfacial properties, including a combination of surfactant and solid particle characteristics when adsorbed at the oil-water interface. [5][6][7][8][9] Furthermore, the incorporation of numerous monomers through copolymerization enhances the ability of polymer-based microgels to exhibit exceptional sensitivity to diverse environmental stimuli.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Pickering emulsions that are responsive to multiple stimuli have a wider range of applications and future prospects. 3,4…”
Section: Introductionmentioning
confidence: 99%
“…However, the therapeutic efficacy of the generated antigens was far from satisfactory. Indeed, for efficient cancer vaccine design, antigens are the only essential prerequisite for priming multiple specific T cell epitopes. , An ideal cancer vaccine requires the efficient delivery of antigens and adjuvants into draining lymph nodes (LNs) and subsequently facilitates their uptake by antigen-presenting cells (APCs) to initiate a series of events activating the host’s own immune system. , Hence, the use of nanotechnology to achieve personalized antigen generation and adjuvants has attracted substantial attention in the past few years. For instance, Chen et al.…”
mentioning
confidence: 99%