Aggregation phenomenon of PEG-grafted chitosan in aqueous solution

Ouchi, Tatsuro; Nishizawa, Hidetoshi; Ohya, Yusuke

doi:10.1016/s0032-3861(97)10020-9

Cited by 143 publications

(82 citation statements)

References 17 publications

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“…In this work, ibuprofen was incorporated into the fibrous mats in two different methods: electrostatically conjugated during the electrospinning process and covalently conjugated to the PEG-g-chitosan prior to spinning. This tri-component system had unique properties of being soluble in organic solvents, while being insoluble in neutral pH water (Ouchi et al, 1998). It was also demonstrated that the hydrophilicity, membrane shrinkage, and rate of drug release could be controlled within the system.…”

Section: Electrospinning Of Chitosanmentioning

confidence: 96%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

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Section: Electrospinning Of Chitosanmentioning

confidence: 96%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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show abstract

“…The self-assemblednanoparticles are composed of a core of hydrophobic moieties surrounding by a hydrophilic outer shell, which could serve as protection for the carried hydrophobic agents [181][182][183]. By grafting with hydrophobic segments, polysaccharides can form amphiphilically polymeric micelles which enhance water solubility and decrease the toxicity of hydrophobic drugs [145].…”

Section: Self-assembly Polysaccharide Nanoparticlesmentioning

confidence: 99%

Novel nanoparticle materials for drug/food delivery-polysaccharides

Chen

Liu

Wong

2016

Physical Sciences Reviews

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“…Therefore, poly (ethylene glycol) is widely used as a pharmacological polymer with high hydrophilicity, biocompatibility and biodegradability. In recent years, derivative poly (ethylene glycol)-g-derivative chitosan to obtain nanoparticles has been studied by many researchers (Ouchi et al, 1998;Jung et al, 2006) (Park et al, 2008) (Yang et al, 2008b) (Opanasopit et al, 2007). The grafted poly (ethylene glycol) methyl ether onto N-Phthaloyl chitosan chains, aggregated to obtain sphere-like nanoparticles (an et al, 2004).…”

Section: Linear Hydrophobic Moleculesmentioning

confidence: 99%