‘Aggressive’ angiomyxoma: a distinct clinical entity

Behranwala, Kasim A; Thomas, Joseph

doi:10.1016/s0748-7983(03)00104-5

Cited by 60 publications

(81 citation statements)

References 12 publications

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“…2 Radiotherapy and chemotherapy may not have much role due to the low mitotic activity seen. 1 GnRH agonist 3 and tamoxifen have been used successfully in few patients. The response can be assessed by clinical assessment, patient's symptomatology and radiographic findings.…”

Section: Resultsmentioning

confidence: 99%

Aggressive Angiomyxoma Pelvis Presenting as an Ovarian Tumor with Vault Prolapse

Dhaliwal¹,

Aggarwal²,

Nijhawan³

et al. 2012

Journal of Postgraduate Medicine, Education and Research

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Section: Resultsmentioning

confidence: 99%

Aggressive Angiomyxoma Pelvis Presenting as an Ovarian Tumor with Vault Prolapse

Dhaliwal¹,

Aggarwal²,

Nijhawan³

et al. 2012

Journal of Postgraduate Medicine, Education and Research

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“…It is possibly a hormonally responsive neoplasm, inview of it's propensity to occur in females in reproductive age group (Htwe et al, 1995). The differential diagnoses include benign tumors such as myxolipoma, myxoidneurofibroma and myxoid leiomyoma and malignant tumors such as myxofibrosarcoma, myxoid variant of liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma and botryoidrhabdomyosarcoma (Behranwala & Thomas, 2003). The distinctively striking vascular component in aggressive angiomyxoma helps to differentiate from these neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Rare Case of Aggressive Angiomyxoma of the Vulva: A Case Report

shanmugasundaram

Maharajan

2016

CCO

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Aggressive Angiomyxoma (AA) is a rare locally aggressive soft tissue tumor with high chance of local recurrence occuring in young women of reproductive age group. These neoplasms are characterized by a mixture of spindle or stellate cells in a loosely myxoid stroma with prominent vascular component containing large, thickwalled blood vessels. A 35 year old multiparous lady presented with right vulval swelling which was rapidly progressing in size. Local examination revealed a soft fleshy mass occupying whole of the right labia majora. In view of the rapidly enlarging lesion over a short duration, we suspected a soft tissue neoplasm and preceded with wide local excision of the mass with adequate margins in all dimensions, eventhough we did not have a preoperative tissue diagnosis. To our surprise, final histopathology was Aggressive Angiomyxoma (AA). The treatment of choice for Aggressive Angiomyxoma is wide local excision with negative margins and the same was done in our case. Recurrence of the tumor may be avoided by wide local excision with adequate margins. It is possibly a hormonally responsive neoplasm. Treatment with Gonadotropin-releasing hormone is an emerging therapy. Overall prognosis of AA is good.

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“…Значительно реже, а при бере-менности казуистически редко, встречается агрес-сивная ангиомиксома. По структуре она относится к пограничным опухолям мезенхимальной природы, не метастазирует, но отличается высокой локальной агрессивностью и связанным с ней рецидивировани-ем процесса после хирургического лечения [1,6]. Именно эти признаки позволили T. Steeper и J. Rosai [6] в 1983 г. предложить термин «агрессивная ангио-миксома» для особого типа мягкотканной гинеколо-гической опухоли.…”

Section: Discussionunclassified

“…Насколько это критично? В проведенных ранее исследованиях [1,14] показано, что максимально радикальное и неполное удаление опухоли даже без проведения лучевой и химиотера-пии одинаково часто сопровождается рецидивом опухолевого роста -до 30-40%. В связи с этим все пациенты, независимо от размеров опухоли и объема проведенной операции, подлежат наблюдению на протяжении продолжительного времени (десятиле-тия) с проведением МРТ в динамике.…”

Section: Discussionunclassified