Aggressive angiomyxoma in females: is radical resection the only option?

Chan, Ik Ming; Hon, Edmund; Ngai, Suk Wai; Ng, Tong Yow; Wong, Ling

doi:10.1034/j.1600-0412.2000.079003216.x

Cited by 144 publications

(190 citation statements)

References 7 publications

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“…15 Given these characteristic features, magnetic resonance imaging can be helpful in delineating the extent of disease, in determining patient suitability for surgery, and in continuing clinical follow-up of patients for recurrent tumor. 2,14 PATHOLOGIC FEATURES…”

Section: Radiologic Featuresmentioning

confidence: 99%

Aggressive Angiomyxoma

Sutton¹,

Laudadio²

2012

Archives of Pathology &Amp; Laboratory Medicine

135

155

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Aggressive angiomyxoma is a rare mesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with nonspecific symptoms which are frequently misdiagnosed with more common entities, such as a Bartholin cyst, lipoma, or hernia. Histologic examination reveals a hypocellular and highly vascular tumor with a myxoid stroma containing cytologically bland stellate or spindled cells. The tumor cells are characteristically positive for estrogen and progesterone receptors, suggesting a hormonal role in the development of the tumor. Chromosomal translocation of the 12q13-15 band involving the HMGA2 gene has been described. Surgical excision is the treatment of choice, although treatment with gonadotropin-releasing hormone agonists is an emerging therapy. Metastases are exceedingly rare, and overall, the prognosis is good.

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Section: Radiologic Featuresmentioning

confidence: 99%

Aggressive Angiomyxoma

Sutton¹,

Laudadio²

2012

Archives of Pathology &Amp; Laboratory Medicine

135

155

View full text Add to dashboard Cite

show abstract

“…2 Radiotherapy and chemotherapy may not have much role due to the low mitotic activity seen. 1 GnRH agonist 3 and tamoxifen have been used successfully in few patients. The response can be assessed by clinical assessment, patient's symptomatology and radiographic findings.…”

Section: Resultsmentioning

confidence: 99%

“…1 The aim of surgery should be to excise as much as possible without causing urinary or anorectal dysfunction. Recurrence is local and reported in 36 to 72%.…”

Section: Resultsmentioning

confidence: 99%

Aggressive Angiomyxoma Pelvis Presenting as an Ovarian Tumor with Vault Prolapse

Dhaliwal¹,

Aggarwal²,

Nijhawan³

et al. 2012

Journal of Postgraduate Medicine, Education and Research

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“…It is a kind of mysenchymal tumor mainly located in women's pelvic and perineum during their reproductive age, usually between the second and fourth decade. The incidence rate between male and female is about 1:6 [2,3]. Though in most cases it looks like a benign tumor, there are still cases of metastasis and led to the death of the patients reported in articles [4,5].…”

Section: Discussionmentioning

confidence: 99%

Aggressive Angiomyxoma: Two Case Reports and Review of the Literature

Cao¹

2017

Int J Radiol Imaging Technol

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Aggressive Angiomyxoma (AA) is a kind of rare, low grade myofibroblastic neoplasm with high risk of local recurrence mainly for the character of locally aggressive and misdiagnosis as other soft tissue mass in the pelvis. The "laminated or swirled sign" of swirled strands of low-signal intensities in T2WI is the diagnostic sign for the layered configuration of AA. We report two cases with contrast enhanced CT and Dynamic Contrast Enhancement (DCE) MRI to show the characteristic imaging features and our findings about AA in enhanced CT and DCE MRI. KeywordsAggressive Angiomyxoma (AA), Laminated or Swirled Sign, Magnetic Resonance Imaging (MRI), X-ray Computed Tomography (X-ray CT), Multiplanner Reformation (MPR), Diffusion Weighted Imaging (DWI), Apparent Diffusion Coefficient (ADC) Case RepoRt Case OneA 29-year-old woman was incidentally found a mass in her vagina. She was asymptomatic and was diagnosed as fibroma by biopsy. The CTs can show a well-limited mass with low density compared to muscle located in the left pelvic cavity (Figure 1a). After iodine contrast injection, the mass showed a progressive and heterogeneous enhancement without any layered character (Figure 1b). MRI showed a big mass extending into the obturator foramen and ischiorectal fossa, displacing the gluteus, uterus and vagina without invading (Figure 2a). The mass showed ho-

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Aggressive angiomyxoma in females: is radical resection the only option?

Cited by 144 publications

References 7 publications

Aggressive Angiomyxoma

Aggressive Angiomyxoma

Aggressive Angiomyxoma Pelvis Presenting as an Ovarian Tumor with Vault Prolapse

Aggressive Angiomyxoma: Two Case Reports and Review of the Literature

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