Aggressive angiomyxoma of the liver: a case report and literature review

Sato, Koki; Ohira, Masaichi; Shimizu, Seiichi; Kuroda, Shintarou; Ide, Kentaro; Ishiyama, K.; Kobayashi, Tsuyoshi; Tahara, Hiroyuki; Shiroma, Noriyuki; Arihiro, Koji; Imamura, Michio; Chayama, Kazuaki; Ohdan, Hideki

doi:10.1186/s40792-017-0365-4

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…It does not typically invade local structures such as the rectum, vagina, bladder, and urethra; thus, patients rarely experience obstructive symptoms from even quite large growths, but rather have nonspecific symptoms. Interestingly, there have been 7 cases reporting AAM originating outside the pelvic region ( Sato et al, 2017 ). It is managed primarily with wide surgical resection ( Steeper and Rosai, 1983 ).…”

Section: Introductionmentioning

confidence: 99%

A persistent mass: A case of aggressive Angiomyxoma of the vulva

Brzezinska¹,

Clements²,

Rath³

et al. 2018

Gynecologic Oncology Reports

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We present a case of aggressive angiomyxoma of the vulva. The patient presented with a persistent, enlarging vulvar mass, initially misdiagnosed as a Bartholin gland cyst. The patient underwent wide local excision, which resulted in total resection of the mass. Final pathology was consistent with aggressive angiomyxoma, a rare soft tissue tumor with a predilection for the female pelvis. Though rare, it is important to consider in the differential diagnosis of a pelvic mass, given the locally aggressive nature of this tumor and propensity for recurrence.

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Section: Introductionmentioning

confidence: 99%

A persistent mass: A case of aggressive Angiomyxoma of the vulva

Brzezinska¹,

Clements²,

Rath³

et al. 2018

Gynecologic Oncology Reports

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“…Thick-walled vessels and a conspicuous vasculature help to distinguish AAM from other malignant and benign myxoid soft tissue tumours of the genital tract and perineum including myxoma, myxoid neurofibroma, angiomyofibroblastoma, spindle cell lipoma, myxoid liposarcoma and leiomyoma 7. Further negativity for S100, β-catenin, MDM-2 as well as lack of cellular atypia ruled out other differential diagnoses 8. In our case, in addition to these histological features the microscopic evaluation of the distinct solid white nodular areas in the growth showed an intense lymphocytic reaction around the tumour, not well described in earlier reports.…”

Section: Discussionmentioning

confidence: 99%

Rare paratesticular aggressive angiomyxoma with negative oestrogen and progesterone receptors in a male patient

2018

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Aggressive angiomyxoma (AAM) is a rare mesenchymal myxoid tumour localised to the pelvis and/or perineum in adult females in reproductive age group. AAM is very rare in males, with <50 cases described in literature, and involves scrotum, spermatic cord and perineum. It is slow growing, with a marked tendency for local recurrence after excision, but without metastatic potential. We present a rare case of a paratesticular AAM in a man aged 53 years. Tumour cells were immunoreactive for desmin, smooth muscle actin (SMA), vimentin, CD34 and were negative for S100. Unlike AAMs in females which express oestrogen receptor (ER) and/or progesterone receptor (PR) in >90% cases, the tumour cells in our case were negative for ER and PR, suggesting that the hypothesis that these markers play a role in tumour development and pathogenesis, does not apply in males. Androgen receptor positivity was noted in 2%-5% tumour cells.

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“…Female/male incidence ratio is 6:1 1 . Generally, this tumour is found in the pelvic and perineal region of female but there are cases with intrabdominal AAM located in liver and pelvic ureter 2,3 . Patients with perineal AAM usually present with a nontender, edematous lesion which is found as a reducible mass in physical examination 4,5,6 .…”

Section: Introductionmentioning

confidence: 99%

Aggressive Angiomyxoma: A Rare Perineal Mass

Özsoy

Çolapkulu

Gapbarov

et al. 2019

Int. J. Hum. Health Sci.

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Aggressive angiomyxoma (AAM) is a rare tumour that usually occurs in females at reproductive ages and affects pelvic region. We herein report a case of perineal AAM to conribute to the literature about pathological features and clinical outcomes of this tumour. A 36 year old female with no history of chronic diseases presented to our hospital with a nontender perineal mass. The mass was present for two years and it first appeared during pregnancy. She underwent surgery for local resection. The histology of the mass was consistent with AAM and multifocal extention into surgical margins was observed. With immunohistochemical staining the tumor was positive for desmin, CD31, CD34, ER and PR; poorly focal positive for SMA and negative for S-100. Ki67 was less than 1%. Due to surgical margin positivity she had a second operation. After the resection with clear margins, patient showed no signs of reccurence for 7 months. Resections with positive surgical margins were mostly concluded as reccurent with wide time range and reccurence rates, extended surgical resection is gold standard for management of this tumour.International Journal of Human and Health Sciences Vol. 03 No. 03 July’19. Page: 172-174

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Aggressive angiomyxoma of the liver: a case report and literature review

Cited by 9 publications

References 17 publications

A persistent mass: A case of aggressive Angiomyxoma of the vulva

A persistent mass: A case of aggressive Angiomyxoma of the vulva

Rare paratesticular aggressive angiomyxoma with negative oestrogen and progesterone receptors in a male patient

Aggressive Angiomyxoma: A Rare Perineal Mass

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