Aggressive behavior in transgenic animal models: A systematic review

Jager, Amanda; Maas, Dorien A.; Fricke, Kim; Vries, Rob B. de; Poelmans, Geert; Glennon, Jeffrey

doi:10.1016/j.neubiorev.2017.09.028

Cited by 15 publications

(8 citation statements)

References 191 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Male mice will also cross an electrified grid [ 56 ] and exhort efforts [ 57 , 58 ] to reach and attack a subordinate. Whether aggression is also rewarding for females remains unresolved, since most domesticated female rodents typically do not present aggression outside the postpartum period [ 27 , 33 , 59∗ , 60∗ , 61 ]. Some insights might come from the Syrian hamster, where females showed a conditioned place preference for a chamber associated with aggressive encounters with males [ 62 ].…”

Section: Sex Differences In Social Motivation and Social Displaysmentioning

confidence: 99%

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Zilkha

Sofer

Kashash

et al. 2021

Current Opinion in Neurobiology

View full text Add to dashboard Cite

Social animal species present a vast repertoire of social interactions when encountering conspecifics. Reproduction-related behaviors, such as mating, parental care, and aggression, are some of the most rewarding types of social interactions and are also the most sexually dimorphic ones. This review focuses on rodent species and summarizes recent advances in neuroscience research that link sexually dimorphic reproductive behaviors to sexual dimorphism in their underlying neuronal circuits. Specifically, we present a few possible mechanisms governing sexually-dimorphic behaviors, by hypothalamic and reward-related brain regions. Sex differences in the neural response to social isolation in adulthood are also discussed, as well as future directions for comparative studies with naturally solitary species.

show abstract

Section: Sex Differences In Social Motivation and Social Displaysmentioning

confidence: 99%

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Zilkha

Sofer

Kashash

et al. 2021

Current Opinion in Neurobiology

View full text Add to dashboard Cite

show abstract

“…The paired social ranking-associated behavioral test used in this study has been routinely performed in chicken behavioral analysis [154,213,218]. The rationale and cellular mechanisms of the test is similar to the resident-intruder test which is a standardized method used in rodents for detecting social stress-induced aggression and violence [219,220].…”

Section: Probiotic Bacillus Subtilis and Aggressionmentioning

confidence: 99%

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Cheng¹,

Jiang²,

Hu³

2019

Oral Health by Using Probiotic Products

View full text Add to dashboard Cite

Intestinal bacteria release various neuroactive compounds directly or indirectly regulating brain function to modulate host health and behavior through the gut-brain axis. Probiotics have been used as dietary supplements to target gut microbiota (microbiome) for prevention or therapeutic treatment of various diseases including mental disorders. In our study, chickens were used as an animal model to assess, if dietary supplementation of probiotic, Bacillus subtilis, reduces aggressive behaviors following social challenge. Chickens of an aggressive line were housed in single-hen cages. At 24 weeks of age, the hens were paired with similar body weight to identify the dominance rank (day 0). The subordinate and dominant of each pair were fed a regular layer diet or the diet mixed with 250 ppm probiotics for 2 weeks, then the second behavior test was performed between the same pair (day 14). The display of aggressive behaviors in the regular diet-fed chickens was not affected between the levels at day 0 and day 14, while the frequency of threat and aggressive pecking were reduced in the probiotic-fed chickens compared to the levels at day 0. These results suggest dietary probiotic, Bacillus subtilis, could be a suitable strategy for increasing hosts' mental health.

show abstract

“…The aggressive behavior observation was conducted in a novel cage at the age of 7th, 15th and 18th weeks (Saline vs. Trp; n 7th = 7 pairs, n 15th = 6 pairs, n 18th = 9 pairs), and 19th week (Saline vs. Saline, Trp vs. Trp; n 19th = 4 pairs). The rationale and cellular mechanisms of the test is like the resident-intruder test which is a standardized method used in rodents for detecting social stress-induced aggression and violence [ 36 ]. Birds were paired based on their BW, and behaviors were recorded to a DVR system for a 30-min period.…”

Section: Methodsmentioning

confidence: 99%

Embryonic Exposure to Tryptophan Yields Bullying Victimization via Reprogramming the Microbiota-Gut-Brain Axis in a Chicken Model

Huang

Peng

et al. 2022

Nutrients

View full text Add to dashboard Cite

Maternal metabolic disorder during early pregnancy may give rise to emotional and behavioral disorders in the child, vulnerable to bullying. Placental tryptophan fluctuation consequently disrupts offspring gut microbiome and brain neurogenesis with long-lasting physiological and social behavioral impacts. The aim of this study was to examine the hypothesis that the excess gestational tryptophan may affect children’s mental and physical development via modifying the microbiota-gut-brain axis, which lays the foundation of their mental status. Chicken embryo was employed due to its robust microbiota and independence of maternal influences during embryogenesis. The results indicated that embryonic tryptophan exposure reduced body weight and aggressiveness in the male offspring before and during adolescence. Additionally, the relative gut length and crypt depth were increased, while the villus/crypt ratio was decreased in tryptophan treated roosters, which was corresponding to the changes in the cecal microbiota composition. Furthermore, the catecholamine concentrations were increased in tryptophan group, which may be associated with the alterations in the gut microbiome and the gut-brain axis’s function. These changes may underlie the sociometric status of bullying; clarify how gestational tryptophan fluctuation compromises bullying and provide a strategy to prevent bullying by controlling dietary tryptophan and medication therapy during pregnancy.

show abstract

Aggressive behavior in transgenic animal models: A systematic review

Cited by 15 publications

References 191 publications

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Embryonic Exposure to Tryptophan Yields Bullying Victimization via Reprogramming the Microbiota-Gut-Brain Axis in a Chicken Model

Contact Info

Product

Resources

About