Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not?

Ghazali, Naseem; Bakri, Marina Mohd; Zain, Rosnah Binti

doi:10.1034/j.1600-0714.2003.00180.x

Cited by 59 publications

(82 citation statements)

References 38 publications

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“…The results of the various case series are shown in table 1. Among the found series, the authors of the study by Ghazali et al (22) were not able to confirm that their cases could be diagnosed as PVL. Therefore, this series was not included in the table.…”

Section: Resultsmentioning

confidence: 68%

“…Generally, diagnosis is made according to Hansen's first definition of PVL in 1985, not taking into account the latter ones. This creates doubt about whether all published PVL cases are indeed PVL, as has been stated by several authors (22)(23)(24). As a result of this, we find it necessary to elaborate specific diagnostic criteria for PVL.…”

Section: Introductionmentioning

confidence: 75%

“…There are only two studies, one by Ghazali et al (22) and another by Gandolfo et al (20), which apply a set of diagnostic criteria to their respective cases, although these are just a transcription of Hansen's definition. Thus, Ghazali et al (22) establish the following criteria: 1. The lesion starts as homogenous leukoplakia without evidence of dysplasia at the first visit.…”

Section: Discussionmentioning

confidence: 99%

“…As reported in previous case series regarding PVL, women (21) are affected more often than men. There is probably no racial preference (22). The mean age at the time of diagnosis is over 60 years.…”

Section: Introductionmentioning

confidence: 99%

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Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

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Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. Eventually, PVL tends to become multifocal with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions may occur both in smokers and nonsmokers. Nevertheless, at present, the aetiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria. Therefore, the aim of this study is to propose a set of diagnostic criteria to allow for the early and objective identification of PVL cases, and thereby conduct an adequate management. The proposal includes five major criteria and four minor criteria, as well as specific combinations among them in order to establish a correct and objective diagnosis of proliferative verrucous leukoplakia.

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Section: Resultsmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

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“…Ghazali et al, [23] suggested the following criteria for the diagnosis of PVL: It also helps in excluding other recognized white lesions. The site of the biopsy should be from symptomatic area and if the lesion is asymptomatic, it should be taken from red or indurated areas [4,17].…”

Section: Leukoplakia and Epstein Barr Virus (Ebv)mentioning

confidence: 99%

Leuloplakia - Review of A Potentially Malignant Disorder

Abidullah

Grover²,

Gaddikeri

et al. 2014

JCDR

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Potentially malignant lesions of the upper aerodigestive tract

Dreyer

Kreisel

2011

Journal of Biophotonics

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Mucosal lesions of the upper aerodigestive tract usually concern the squamous epithelium of the surface. Many precancerous alterations now designated as potentially malignant are caused by DNA damage resulting from long term exposure to tobacco and alcohol consumption. The distinction from conditions with a similar phenotype but caused by different reasons such as viral infection may be difficult. Furthermore, a magnitude of similar appearing lesions with different clinical background and different biological behavior are discussed in this paper.

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Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not?

Abstract: In retrospect, none of the cases fulfilled the original PVL criteria, although three cases were suggestive of PVL. Nevertheless, these findings do not necessarily preclude the existence of PVL as a clinicopathological entity in Malaysian population.

Cited by 59 publications

References 38 publications

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Leuloplakia - Review of A Potentially Malignant Disorder

Potentially malignant lesions of the upper aerodigestive tract

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