Leuloplakia - Review of A Potentially Malignant Disorder

Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In the present study, for the first time we established the cancerous cell line OSCC-BD induced by B(a)P/DMBA mixture and transformed from dysplastic oral leukoplakia cell line DOK. Cell morphology, proliferation ability, migration ability, colony formation, and tumorigenicity were studied and confirmed the malignant characteristics of OSCC-BD cells. We further identified the differential proteins between DOK and OSCC-BD cells by stable isotope dimethyl labeling based quantitative proteomic method, which showed 18 proteins up-regulated and 16 proteins down-regulated with RSD < 8%. Differential proteins are mainly related to cell cycle, cell proliferation, DNA replication, RNA splicing and apoptosis. Abberant binding function, catalysis activity and transportor activity of differential proteins might contribute to the malignant transformation of OLK. Of the 34 identified differential proteins with RSD < 8%, 13 novel cancer-related proteins were reported in the present study. This study might provide a new insight into the mechanism of OLK malignant transformation and the potent biomarkers for early diagnosis, meanwhile further facilitate the application of the quantification proteomics to carcinogenesis research.

show abstract

“…Prevalence of oral leukoplakia has ranged from 0.2% to 3.6%. Various studies have shown 0.6% to 20% rate of malignant transformation of OLK 6 .…”

mentioning

confidence: 99%

Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach

Yan

Zhao

et al. 2015

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Our study found pigmentation in leukoplakia associated with the tumor in 7 cases (28%). Leukoplakia is one of the most common potentially malignant disorders of the oral cavity ( 33 ). Matsumoto et al ( 21 ) stated that the presence of a pigment in a white mucosal lesion might be a sign of a pigmented pre-cancerous lesion or pigmented SCC.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

Pigmented oral squamous cell carcinoma (POSCC) is a rare and underrecognized pathological variant of oral squamous cell carcinoma (OSCC). The current study aimed to evaluate the clinicopathological characteristics, treatment outcomes and prognosis of patients with POSCC and to investigate its oncological properties using immunohistochemical studies. A total of 1,512 patients were pathologically diagnosed with squamous cell carcinoma of the oral cavity, and were treated at the Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University between January 2001 and December 2018. A total of 25 patients had POSCC and underwent radical surgery. Of these 25 patients, 23 presented with early T stage disease. Additionally, 22 patients were negative for cervical lymph nodes metastasis. Only one patient had local recurrence. The 5-year disease-free and disease-specific survival rates were 86.6 and 95.8%, respectively. Immunohistochemically, a high percentage of POSCC exhibited low p53 and Ki-67, preserved E-cadherin or negative vimentin expression. The results suggested that POSCC tends to exhibit non-aggressive oncological behavior and demonstrates a good prognosis.

show abstract

Laser Use in Minor Oral Surgery

Hamadah

2023

Textbooks in Contemporary Dentistry

View full text Add to dashboard Cite

Leuloplakia - Review of A Potentially Malignant Disorder

Cited by 12 publications

References 23 publications

Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach

Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach

Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma

Laser Use in Minor Oral Surgery

Contact Info

Product

Resources

About